Protein Degradation The Ubiquitin Proteasome System 1st Edition by John Mayer, Aaron Ciechanover, Martin Rechsteiner 3527308075 9783527308378

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Product details:

ISBN 10: 3527308075 

ISBN 13: 9783527308378

Author: R. John Mayer, Aaron J. Ciechanover, Martin Rechsteiner

The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway.
Drawing on the combined knowledge of the world’s leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation.
Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.
Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation. 

Table of contents:

1. Molecular chaperones and the ubiquitin-proteasome system / Cam Patterson and Jörg Höhfeld

2. Molecular dissection of autophagy in the yeast Saccharomyces cerevisiae / Yoshinori Ohsumi

3. Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes / Huib Ovaa … [et al.]

4. MEKK1: dual function as a protein kinase and a ubiquitin protein ligase / Zhimin Lu and Tony Hunter

5. Proteasome activators / Andreas Förster and Christopher P. Hill

6. The proteasome portal and regulation of proteolysis / Monika Bajorek and Michael H. Glickman

7. Ubiquity and diversity of the proteosome system / Keiji Tanaka, Hideki Yashiroda, and Shigeo Murata

8. Proteasome-interacting proteins / Jean E. O’Donoghue and Colin Gordon

9. Structural studies of large, self-compartmentalizing proteases / Beate Rockel, Jürgen Bosch, and Wolfgang Baumeister

10. What the archaeal PAN – proteasome complex and bacterial ATP-dependent proteases can teach us about the 26S proteasome / Nadia Benaroudj, David Smith, and Alfred L. Goldberg

11. Biochemical functions of ubiquitin and ubiquitin-like protein conjugation / Mark Hochstrasser

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Tags: John Mayer, Aaron Ciechanover, Martin Rechsteiner, Proteasome