Bio Implant Interface Improving Biomaterials and Tissue Reactions 1st Edition by Ellingsen, Lyngstadaas 0367395231 9780367395230

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ISBN 10: 0367395231

ISBN 13: 9780367395230

Author: J.E. Ellingsen, S.P. Lyngstadaas

Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine , the control and patterning

Bio Implant Interface Improving Biomaterials and Tissue Reactions 1st Table of contents:

Section I Success and Failure of Bone–Implant Attachments: An Evidence-Based Approach

1 Role of Implant Surface Properties on the Clinical Outcome of Osseointegrated Oral Implant Therapy: An Evidence-Based Approach

Contents

1.1 Introduction

1.2 Materials and Methods

1.3 Results

1.4 Discussion

1.5 Conclusions

Acknowledgments

References

Section II Can Implant Macro Design and Micro Texturing Improve Bone Response?

2 Toward an Optimized Dental Implant Design

Contents

2.1 Introduction

2.2 Wolff’S Law and Its Implications for Dental Implant Design

2.3 Determining Which Parts of an Implant should be Provided with Retention Elements

2.4 Ideal Surface Roughness from A Biomechanical Angle

2.5 Ideal Implant Thread

2.6 The Implant–Abutment Interface

2.7 Summary

References

3 Implant Surface Design for Development and Maintenance of Osseointegration

Contents

3.1 Introduction

3.2 Implant Maintenance: Avoidance of Crestal Bone Loss

3.3 Sintered Porous Surfaces: Rationales of Design and Use

3.4 Surface Modification for Enhancing Osteoconductivity

3.5 Maintenance of Osseointegration and Implant Design

3.6 Summary

References

4 Bone Response to Surface Roughness: Measurements and Results from Experimental and Clinical Studies

Contents

4.1 Introduction

4.2 Surface Roughness

References

5 From Microroughness to Resorbable Bioactive Coatings

Contents

5.1 Introduction

5.2 Materials and Methods

5.3 Discussion

References

Section III Cell and Tissue Reactions to Biomaterials

6 Improving the Bio-Implant Interface by Controlling Cell Behavior Using Surface Topography

Contents

6.1 Introduction

6.2 Strategy in Selecting Potential Experimental Systems

6.3 Cell Responses to Topography

6.4 Cell Population Density

6.5 Role of Extracellular Matrix

6.6 Cell Responses to Surfaces Produced by Industrial Processes

6.7 Cell Selection in an in Vivo Model

6.8 Conclusions

Acknowledgment

References

7 Osteoblast Response to Pure Titanium and Titanium Alloy

Contents

7.1 Introduction

7.2 Titanium Dioxide: Dental Implant or Orthopedic Interface to Bone

7.3 Proteomics as the Future

7.4 Conclusions

Acknowledgments

References

8 Biomedical Implant Surface Topography and Its Effects on Osteoblast Differentiation in Vitro

Contents

8.1 Introduction

8.2 Methods and Materials

8.3 Results and Discussion

8.4 Summary

Acknowledgments

References

9 Cellular Interactions at Commercially Pure Titanium Implants

Contents

9.1 Introduction

9.2 Cellular Diversity and Osseointegration

9.3 Understanding Biological Conditioning of the Endosseous Implant Surface

9.4 Osteoinduction is a Function of the Implant–Resident Cell Population

9.5 Early Responses to Osteoinductive Signals

9.6 Potential Specialization of Bone Formation at Implants

9.7 Summary

References

10 A Selection of Oral Implant Materials Based on Experimental Studies

Contents

10.1 Introduction

10.2 Commercially Pure Titanium

10.3 Titanium Alloys

10.4 Surface-Modified C.P. Titanium and Ti-6Al-4V

10.5 Tantalum

10.6 Niobium

10.7 Zirconium

10.8 Hafnium

10.9 Vitallium (Cobalt/Chromium Alloy)

10.10 Summary

Acknowledgments

References

11 Possibilities of Improving Implants and Regenerating Dentoalveolar Tissues by Tissue Engineering Using Stem Cells and Growth Factors

Contents

11.1 Introduction

11.2 Stem Cells and their Potential in Tissue Regeneration

11.3 Use of Bioactive Signal Molecules in Induction of Stem Cell Differentiation

11.4 Possibilities for Improving or Replacing Implants through Tissue Engineering

References

12 Critical Issues in Endosseous Peri-Implant Wound Healing

Contents

12.1 Introduction

12.2 Osteoconduction

12.3 De Novo Bone Formation

12.4 Bone Bonding

12.5 Concluding Remarks

References

Section IV Extracellular Matrix Biology and Biomineralization in Bone Formation and Implant Integration

13 Initiation and Modulation of Crystal Growth in Skeletal Tissues: Role of Extracellular Matrix

Contents

13.1 Introduction

13.2 Role of Organic Matrix

13.3 Summary

References

14 Use of a Matrix Scaffold for Tissue Engineering and Bone Regeneration

Contents

14.1 Introduction

14.2 Materials and Methods

14.3 Results

14.4 Discussion

Acknowledgments

References

15 Inducing Bone Growth Using Extracellular Matrix Proteins

Contents

15.1 Introduction

15.2 Surface Molecular Recognition

15.3 Growth Factors and Extracellular Matrix Proteins

15.4 Enamel Matrix Proteins for Bone Growth

15.5 Conclusion

References

Section V Surface Chemistry, Biochemistry, and Molecules: How do they Interact with Biological Environment?

16 How Surfaces Interact with the Biological Environment

Contents

16.1 Introduction

16.2 The Biomaterial Interface

16.3 Protein Adsorption

16.4 Blood Plasma–Surface Interactions

16.5 Immune System Recognition of Biomaterials

16.6 Cells at Interfaces

16.7 Final Remarks

References

17 Osteocapacities of Calcium Phosphate Ceramics

Contents

17.1 Introduction

17.2 Osteogenic Lineage

17.3 Cell–Substrate Adhesion

17.4 Oral Implant Materials

17.5 Osteocapacities of CP Ceramics

17.6 Sputter Deposition of Cap Coatings

17.7 Interface Physics of Sputtered Cap Coatings

17.8 In Vitro Cell Behavior of Sputtered Cap Coatings

17.9 In Vivo Bone Behavior of Sputtered Cap Coatings

17.10 Conclusion and Final Remarks

References

18 Increasing Biocompatibility by Chemical Modification of Titanium Surfaces

Contents

18.1 Introduction

18.2 Surface Modifications

References

19 Use of Molecular Assembly Techniques for Tailoring Chemical Properties of Smooth and Rough Titanium Surfaces

Contents

19.1 Introduction

19.2 Surface Modifications of Titanium by Alkane Phosphate Self-Assembled Monolayers to Control Physicochemical Properties

19.3 Molecular Assembly Systems to Control Non-Specific Protein Adsorption and Specific Interactions with Cells

19.4 Conclusions and Outlook

Acknowledgments

References

Section VI Development and Application of Scientific Data: Regulatory and Commercial Aspects

20 Development and Application of Scientific Data: Do Industry and Academia have Different Scientific Perspectives?

21 Medical Devices: Regulatory Perspectives and Aspects of Regulatory Risk Management

Contents

21.1 Regulation of Medical Devices

21.2 Definitions of Medical Devices

21.3 Classification

21.4 Regulatory Issues Concerning Medical Devices Used in Dentistry

21.5 Risk Analysis, Assessment, and Management

21.6 Information Sources

Section VII Inventive Forward Looks: Where do We Go from Here?

22 Self-Assembling and Biomimetic Biomaterials

Contents

22.1 Introduction

22.2 Tissue Engineering

22.3 Design and Synthesis of an Extracellular Matrix

22.4 Mineralization of Nanofibers

22.5 Chemically Customized Extracellular Matrices

22.6 Conclusions

Acknowledgments

References

23 The Inert–Bioactivity Conundrum

Contents

23.1 Introduction

23.2 Inertness and Bioactivity: How Materials Control Host Response

23.3 Clinical Experience with Implanted Medical Devices

23.4 Bioactive Surfaces

23.5 General Discussion and Conclusions

References

24 Enhancing the Processes of Discovery and Innovation for Optimal Host Response at Implant Surfaces

Contents

24.1 Introduction

24.2 Methods and Materials

24.3 Data and Discussion

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