Principles of Developmental Genetics 1st Edition by Sally Moody 9780123695482 0123695481

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Product details:

ISBN 10: 0123695481

ISBN 13: 9780123695482

Author: Sally A. Moody

Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.

• Includes new research not previously published in any other book on the molecular genetic
processes that regulates development
• Chapters present a broad understanding on the application of animal model systems, allowing
researchers to better treat clinical disorders and comprehend human development
• Relates the application of new technologies to the manipulation of stem cells, causes of
human birth defects, and several human disease conditions
• Each chapter includes a bulleted summary highlighting clinical aspects of animal models

Table of contents:

Section I: The Impact of Genetic and Genomic Tools on Developmental Biology
Chapter 1: Untangling the Gordian Knot: Cell Signaling Events That Instruct Development
Chapter 2: Finding Gene Expression Changes Using Microarray Technology
Chapter 3: Chemical and Functional Genomic Approaches to Study Stem Cell Biology and Regeneration
Chapter 4: Assessing Neural Stem Cell Properties Using Large-Scale Genomic Analysis
Chapter 5: Epigenetic Influences on Gene Expression Pathways
Chapter 6: New Insights into Vertebrate Origins
Chapter 7: Understanding Human Birth Defects Through Model Organism Studies

Section II: Early Embryology, Fate Determination, and Patterning
Chapter 8: Germ Line Determinants and Oogenesis
Chapter 9: Patterning the Anterior–Posterior Axis During Drosophila Embryogenesis
Chapter 10: Anterior–Posterior Patterning in Mammals
Chapter 11: Signaling Cascades, Gradients, and Gene Networks in Dorsal/Ventral Patterning
Chapter 12: Early Development of Epidermis and Neural Tissue
Chapter 13: Formation of the Embryonic Mesoderm
Chapter 14: Endoderm
Chapter 15: Notch Signaling: A Versatile Tool for the Fine Patterning of Cell Fate in Development
Chapter 16: Multiple Roles of T-box Genes

Section III: Gastrulation in Vertebrates
Chapter 17: Gastrulation in Vertebrates
Chapter 18: Regulation of Tissue Separation in the Amphibian Embryo
Chapter 19: Role of the Basement Membrane in Cell Migration
Chapter 20: Epithelial Morphogenesis
Chapter 21: Branching Morphogenesis of Mammalian Epithelia
Chapter 22: The Roles of Ephrin–Eph in Morphogenesis

Section IV: Ectodermal Organs
Chapter 23: Neural Cell Fate Determination
Chapter 24: Pathfinding and Patterning of Axonal Connections
Chapter 25: Retinal Development
Chapter 26: Neural Crest Determination
Chapter 27: Determination of Preplacodal Ectoderm and Sensory Placodes
Chapter 28: Molecular Genetics of Tooth Development
Chapter 29: The Inner Ear
Chapter 30: Craniofacial Formation and Congenital Defects

Section V: Mesodermal Organs
Chapter 31: Induction of the Cardiac Lineage
Chapter 32: Heart Patterning and Congenital Defects
Chapter 33: Blood Vessel Formation
Chapter 34: Blood Induction and Embryonic Formation
Chapter 35: Topics in Vertebrate Kidney Formation: A Comparative Perspective
Chapter 36: Development of the Genital System
Chapter 37: Diaphragmatic Embryogenesis and Human Congenital Diaphragmatic Defects
Chapter 38: Formation of Vertebrate Limbs
Chapter 39: Skeletal Development

Section VI: Endodermal Organs
Chapter 40: Patterning the Embryonic Endoderm into Presumptive Organ Domains
Chapter 41: Developmental Genetics of the Pulmonary System
Chapter 42: Pancreas Development and Stem Cells
Chapter 43: Early Liver Development and Hepatic Progenitor Cells
Chapter 44: Intestinal Stem Cells in Physiologic Regeneration and Disease

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