Molecular Neurology 1st Edition by Stephen Waxman 9780123695093 0123695090

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ISBN 10: 0123695090

ISBN 13: 9780123695093

Author: Stephen G. Waxman

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.

* Describes the newest molecular aspects of neurological disorders
* Provides an introduction to neurological disorders for basic scientists
* Updates clinicians and clinical researchers on the most recent developments

Table of contents:

Section I: Principles of Molecular Neurology
Chapter 1: Genetics as a Tool in Neurology
Chapter 2: Neurology and Genomic Medicine
Chapter 3: Mitochondrial Function and Dysfunction in the Nervous System
Chapter 4: Neuronal Channels and Receptors
Chapter 5: Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System
Chapter 6: Metabolic Biopsy of the Brain
Chapter 7: Gene Therapy Approaches in Neurology
Chapter 8: Programmed Cell Death and Its Role in Neurological Disease

Section II: Disorders of Development
Chapter 9: Developmental Neurology: A Molecular Perspective
Chapter 10: Metabolic Diseases of the Nervous System Development
Chapter 11: Genetic Disorders of Neuromuscular Brain Disease

Section III: Stroke and Trauma
Chapter 12: Molecular Mechanisms of Ischemic
Chapter 13: Hemorrhagic Brain Disease
Chapter 14: The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury

Section IV: Degenerative Diseases
Chapter 15: Parkinson Disease: Molecular Insights
Chapter 16: The Molecular Basis of Alzheimer’s Disease
Chapter 17: Polyglutamine Disorders Including Huntington’s Disease
Chapter 18: Friedreich’s Ataxia and Related DNA Loss-of-Function Disorders
Chapter 19: DYT1, An Inherited Dystonia
Chapter 20: Motor Neuron Disease: Amyotrophic Lateral Sclerosis
Chapter 21: Genetic Disorders of the Autonomic Nervous System
Chapter 22: Multiple Sclerosis as a Neurodegenerative Disease

Section V: Disorders of Excitation and Transmission
Chapter 23: Acquired Epilepsy: Cellular and Molecular Mechanisms
Chapter 24: Genetic Epilepsies
Chapter 25: Tourette’s Syndrome

Section VI: Disorders of Sleep and Circadian Rhythms
Chapter 26: Disorders of Sleep and Circadian Rhythms

Section VII: Pain
Chapter 27: Chronic Pain as a Molecular Disorder
Chapter 28: Migraine as a Cerebral Ionopathy with Impaired Central Sensory Processing

Section VIII: Peripheral Nerve Disease
Chapter 29: Myelin Protein Zero and CMT1B: A Tale of Two Phenotypes

Section IX: Neuro-Immunology
Chapter 30: Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis
Chapter 31: Autoimmune and Genetic Disorders of the Neuromuscular Junction and Motor Nerve Terminal
Chapter 32: Paraneoplastic Neurologic Syndromes

Section X: Mitochondrial Disorders
Chapter 33: Mitochondrial Disorders

Section XI: Infectious Disorders
Chapter 34: Molecular Neurology of HIV-1 Infection and AIDS

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Tags: Stephen Waxman, Molecular, Neurology