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Stimuli Responsive Drug Delivery Systems From Introduction to Application 1st Edition by Anil Bajpai, Sandeep Shukla ISBN 1847354181 9781847354181

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Author(s): Bajpai, Anil; Shukla, Sandeep; Saini, Rajesh; Tiwari, Atul
ISBN(s): 9781847354181, 1847354181
Edition: 1
File Details: PDF, 9.17 MB
Year: 2010
Language: english
SKU: EB-4633906 Category: Tags: , , , , , , ,

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ISBN 10: 1847354181 
ISBN 13: 9781847354181
Author: Anil Bajpai, Sandeep Shukla

Stimuli responsive drug delivery systems have emerged as one of the most innovative classes of polymer materials of modern materials science. The polymer architectures exhibiting a large change in their physico chemical behaviors in response to minor signals from the environments have fabricated potentially useful materials for pharmaceutical and biomedical applications. The most advanced stimuli responsive drug delivery systems have also explored a new strategy to design targeted delivery systems to treat complex diseases like cancers and related tumors. Stimuli Responsive Drug Delivery Systems offers a convincing approach to understanding the basic principles of drug delivery process, their mathematical modeling, different types of drug delivery systems, various polymer systems responsive to stimuli such as swelling, pH, temperature, electric and magnetic fields, chemical agents, and more – The material covered in this book provides a wide spectrum of information – academic, research, and professional – for the biomedical, pharmaceutical and polymer chemistry communities. The book also presents the commercial scenario of drug delivery systems and highlights upcoming challenges and existing future prospects of this field. An exhaustive bibliography of the book also enables students and researchers of various disciplines to acquire additional information they may require.

Stimuli Responsive Drug Delivery Systems From Introduction to Application 1st Table of contents:

Part I: Introduction and Fundamental Concepts

Chapter 1: Introduction to Controlled Drug Delivery

  • 1.1 The Need for Controlled Release Systems
  • 1.2 Limitations of Conventional Drug Delivery
  • 1.3 A Classification of Controlled and Responsive Systems

Chapter 2: Principles of Stimuli-Responsive Systems

  • 2.1 What are “Smart” or “Intelligent” Materials?
  • 2.2 The Role of Polymers and Hydrogels in Responsive Systems
  • 2.3 Mechanisms of Drug Release: Swelling, Degradation, and Phase Transition

Chapter 3: Biocompatibility and Biodegradation

  • 3.1 Assessing Biocompatibility of Biomaterials
  • 3.2 Mechanisms of Polymer Biodegradation
  • 3.3 The Importance of Degradation Products

Part II: Classification of Stimuli and Responsive Materials

Section A: Physical Stimuli

Chapter 4: Temperature-Responsive Systems

  • 4.1 Lower Critical Solution Temperature (LCST) and Upper Critical Solution Temperature (UCST)
  • 4.2 Poly(N-isopropylacrylamide) (PNIPAM) and its Derivatives
  • 4.3 Applications in Thermally Triggered Release

Chapter 5: pH-Responsive Systems

  • 5.1 The Role of Ionizable Groups in Polymers
  • 5.2 pH-Sensitive Copolymers
  • 5.3 Applications in Gastrointestinal and Tumor-Targeted Delivery

Chapter 6: Light-Responsive Systems

  • 6.1 Photothermal and Photochemical Triggers
  • 6.2 Use of Photosensitive Moieties and Nanoparticles
  • 6.3 On-Demand Drug Release using Light

Chapter 7: Electric and Magnetic Field-Responsive Systems

  • 7.1 Magnetically Activated Nanoparticles
  • 7.2 Electro-responsive Gels and Polymers
  • 7.3 Applications in Remote-Controlled Delivery

Chapter 8: Ultrasound-Responsive Systems

  • 8.1 The Mechanism of Ultrasound-Induced Drug Release
  • 8.2 Ultrasound-Sensitive Liposomes and Microbubbles
  • 8.3 Applications in Non-Invasive Delivery

Section B: Chemical and Biological Stimuli

Chapter 9: Glucose-Responsive Systems

  • 9.1 The Need for Smart Insulin Delivery
  • 9.2 Glucose Oxidase and Boronic Acid-Based Systems
  • 9.3 In-vitro and In-vivo Studies for Diabetes Management

Chapter 10: Redox-Responsive Systems

  • 10.1 Thiol and Disulfide Bond Cleavage
  • 10.2 Disulfide-Linked Copolymers
  • 10.3 Applications in Intracellular Drug Delivery

Chapter 11: Enzyme-Responsive Systems

  • 11.1 Polymer Degradation by Specific Enzymes
  • 11.2 Enzyme-Substrate Interactions for Controlled Release
  • 11.3 Applications in Targeting Tumors and Inflammatory Sites

Chapter 12: Ion-Responsive and Other Chemical Triggers

  • 12.1 Sensitivity to Metal Ions (e.g., Calcium)
  • 12.2 Systems Responsive to Solvents and Chemical Cues

Part III: Design, Fabrication, and Characterization

Chapter 13: Fabrication Techniques

  • 13.1 Micro- and Nanofabrication Methods
  • 13.2 Emulsion, Nanoprecipitation, and Self-Assembly
  • 13.3 3D Printing of Responsive Scaffolds

Chapter 14: Characterization of Responsive Systems

  • 14.1 Measuring Swelling and Volume Changes
  • 14.2 Rheological and Mechanical Properties
  • 14.3 In-vitro Drug Release Kinetics

Part IV: Applications in Medicine

Chapter 15: Stimuli-Responsive Systems in Cancer Therapy

  • 15.1 Targeted Delivery to Tumor Microenvironments (pH, temperature)
  • 15.2 Reducing Off-Target Toxicity
  • 15.3 Combining Responsive Systems with Imaging

Chapter 16: Applications in Other Clinical Fields

  • 16.1 Ocular Drug Delivery
  • 16.2 Dermal and Transdermal Applications
  • 16.3 Responsive Scaffolds for Tissue Engineering

Chapter 17: Stimuli-Responsive Systems for Gene and Protein Delivery

  • 17.1 The Challenge of Delivering Biologics
  • 17.2 pH- and Redox-Responsive Polyplexes and Nanocarriers
  • 17.3 Controlled Release of Growth Factors

Part V: Challenges and Future Perspectives

Chapter 18: Translation from Lab to Clinic

  • 18.1 Scaling Up Production
  • 18.2 In-vivo Performance and Efficacy
  • 18.3 Regulatory Hurdles and Safety Assessment

Chapter 19: The Future of Responsive Drug Delivery

  • 19.1 Multi-Responsive Systems
  • 19.2 Integration with Diagnostics (Theranostics)
  • 19.3 Wearable and Implantable Devices

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