Advances in Cancer Research 98 1st Edition by George Vande Woude, George Klein 9780120066933 0120066939

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Product details:

ISBN 10: 0120066939

ISBN 13: 9780120066933

Author: George F. Vande Woude and George Klein

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including Central Roles of Mg2+ and MgATP2- in the Regulation of Protein Synthesis and Cell Proliferation: Significance for Neoplastic Transformation; Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer; T-Cell Transformation and Oncogenesis by ã2-Herpesviruses; Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis; Soluble Mediators of Inflammation During Tumor Development; Classical and Non-Classical HLA Class I Antigen and NK Cell Activating Ligand Changes in Malignant Cells: Current Challenges and Future Directions.

Table of contents:

Chapter 1. Central Roles of Mg2+ and MgATP2– in the Regulation of Protein Synthesis and Cell Proli

I. Specific and Nonspecific Stimulators of Cell Proliferation

II. Necessity for Prolonged Stimulation and Increased Protein Synthesis to Induce DNA Synthesis

III. Requirement of RNA and Protein Synthesis for the Initiation of DNA Synthesis

IV. Effects of Inhibitors of Protein Synthesis on Initiation of DNA Synthesis

V. Cyclins and CDKs, Specific Proteins Required for the Transition from the G1 to the S Stages of th

VI. Role of Mg2+ in Growth Regulation

VII. Protein and DNA Synthesis in Very Low Ca2+ with Variations in Mg2+ Concentrations

VIII. Kinetics of Cellular Responsiveness to Mg2+ Limitation in Physiological Ca2+

IX. Mitogen-Induced Increases in Cytosolic Free Mg2+

X. Mg2+ Effects on Diverse Cellular Responses to Growth Factors

XI. Possible Roles of K+, Ca2+, pH, and Na+ in Growth Regulation

XII. Regulation of Protein Synthesis by the PI 3-K and mTOR Pathways

XIII. Role of Cations in Neoplastic Transformation

XIV. Conclusions

References

Chapter 2. Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer

I. Introduction

II. Tonsillar Cancer

III. Human Papillomavirus (HPV)

IV. Human Papillomavirus (HPV) in Tonsillar Cancer

V. HPV and Other Tumors of the Head and Neck

VI. HPV Vaccines

VII. Conclusions

References

Chapter 3. T-Cell Transformation and Oncogenesis by y2-Herpesviruses

I. Natural Occurrence of the Viruses and Pathology

II. Genome Structure

III. Replication and Persistence of T-Lymphotropic Rhadinoviruses

IV. Viral Homologs to Cellular Genes

V. Oncogenesis

VI. Growth Transformation of Human T Cells by Rhadinoviruses

VII. Rhadinovirus Vectors for Gene Therapy

VIII. Conclusions

References

Chapter 4. Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis

I. Introduction

II. Multiple Steps in MHC Class II Antigen Presentation

III. Interfering with Antigen Presentation by MHC Class II Molecules

IV. MHC Class II Molecules in Oncogenesis

V. Conclusions

References

Chapter 5. Soluble Mediators of Inflammation During Tumor Development

I. Introduction

II. Leukocytes and Inflammation

III. Inflammation and Tumor Progression

IV. Conclusions

References

Chapter 6. Classical and Nonclassical HLA Class I Antigen and NK Cell–Activating Ligand Changes in

I. Introduction

II. Detection of HLA Antigen and NK Cell–Activating Ligand Expression in Malignant Lesions

III. Frequency and Molecular Mechanisms Underlying Abnormal HLA Class I Antigen Phenotypes in Malign

IV. Nonclassical HLA Class I Antigen, MICA/B, and ULBP Expression by Malignant Cells

V. Role of Immune Selective Pressure in the Generation of Lesions with Defects in Classical and Nonc

VI. HLA Class I Antigen and HLA Class I-TA–Derived Peptide Complex Expression by Malignant Cells

VII. Conclusions

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