Hormones Genes and Cancer 1st Edition by Brian E Henderson, Bruce Ponder, Ronald K Ross ISBN 0195135768 978-0195135763

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Product details: 

ISBN 10: 0195135768

ISBN 13: 978-0195135763

Author: Brian E. Henderson, Bruce Ponder, Ronald K Ross

Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body’s internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.

Table of contents: 

• Introduction

  • Overview of Cancer Biology
  • The Role of Hormones in Cancer Development
  • The Interplay Between Hormones and Genes in Oncogenesis

• Part 1: The Biological Basis of Cancer

  • Chapter 1: Cancer Cell Biology
    • The Hallmarks of Cancer
    • Cell Cycle Dysregulation and Tumorigenesis
    • Apoptosis and Immortalization of Cancer Cells
  • Chapter 2: Molecular Mechanisms in Cancer
    • Oncogenes and Tumor Suppressor Genes
    • Mutations and Gene Expression Deregulation in Cancer
    • Epigenetic Changes in Cancer Cells

• Part 2: Hormonal Regulation of Cancer

  • Chapter 3: Hormones and Their Receptors
    • Overview of Hormones (Estrogen, Testosterone, Progesterone, etc.)
    • Mechanisms of Hormone Signaling and Receptor Activation
  • Chapter 4: Hormones and Breast Cancer
    • The Role of Estrogen in Breast Cancer Development
    • Hormone Replacement Therapy and Cancer Risk
    • Targeting Hormonal Pathways in Breast Cancer Treatment
  • Chapter 5: Hormones and Prostate Cancer
    • Testosterone and Androgen Receptors in Prostate Cancer
    • Androgen Deprivation Therapy in Prostate Cancer
    • Resistance to Hormonal Therapies in Prostate Cancer

• Part 3: Genetic Factors in Cancer

  • Chapter 6: Cancer Genetics and Inherited Risk
    • Genetic Mutations and Cancer Susceptibility
    • Inherited Cancer Syndromes (e.g., BRCA1, BRCA2, Lynch Syndrome)
  • Chapter 7: Gene Expression and Tumor Microenvironment
    • Tumorigenic Changes in Gene Expression
    • The Role of the Microenvironment in Cancer Progression
  • Chapter 8: The Role of DNA Repair and Cancer
    • Mechanisms of DNA Repair in Cancer Cells
    • Defects in DNA Repair Pathways and Their Role in Cancer

• Part 4: Hormonal and Genetic Interactions in Cancer

  • Chapter 9: Hormone-Induced Genetic Changes
    • How Hormones Influence Gene Expression
    • Epigenetic Modifications Induced by Hormones
  • Chapter 10: Genomic Instability and Hormone Sensitivity
    • Genomic Instability as a Factor in Hormone-Dependent Cancers
    • Role of Chromosomal Abnormalities in Hormonal Cancer Progression
  • Chapter 11: The Role of Growth Factors and Cytokines
    • Growth Factor Signaling in Cancer
    • Interactions Between Hormones and Growth Factor Networks

• Part 5: Therapeutic Approaches Targeting Hormones and Genes

  • Chapter 12: Hormonal Therapy in Cancer
    • Estrogen and Androgen Receptor Modulators
    • Aromatase Inhibitors and Anti-androgens in Cancer Treatment
  • Chapter 13: Targeting Oncogenes and Tumor Suppressors
    • Small Molecule Inhibitors and Targeted Therapies
    • Gene Therapy Approaches in Cancer
  • Chapter 14: Immunotherapy and Hormonal Cancers
    • Immune System Targeting in Hormone-Driven Cancers
    • Hormonal Pathways as Targets for Immunotherapy

• Part 6: Future Directions in Hormones, Genes, and Cancer

  • Chapter 15: Personalized Medicine and Cancer Treatment
    • Advances in Genomic Profiling of Cancer
    • Hormone-Based Precision Therapy in Oncology
  • Chapter 16: Emerging Research Areas
    • Epigenetic Therapies and Hormonal Cancer
    • The Future of Gene Editing in Cancer Treatment
    • Novel Hormone Receptor Targets in Cancer Therapy

• Conclusion

  • Summary of Current Understanding
  • Ongoing Challenges and Future Perspectives in Cancer Research

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Brian E Henderson,Bruce Ponder,Ronald K Ross,Hormones