Tumor Targeting in Cancer Therapy 1st Edition by Michel Pagé 161737251X 9781617372513

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Product details:

ISBN 10: 161737251X 

ISBN 13: 9781617372513

Author: Michel Pagé

After many years of vigorous effort, the use of antibodies to target tumors has become highly successful both clinically and commercially. In Tumor Targeting in Cancer Therapy, Dr. Michel Pagé and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.

Comprehensive and practical, Tumor Targeting in Cancer Therapy summarizes the essentials of tumor targeting as it is practiced today and provides all those engaged in experimental and clinical cancer research the critically established information needed to evaluate new technologies, investigate novel therapeutic agents, and apply them in relevant clinical practice.

Table of contents:

I. A Review
1 The Current Status of Tumor Targeting: A Review
2 Clinical Applications of Targeted Therapeutics

II. Targeting Tumors with Drug Antibody Conjugates
3 Targeting the CD22 Receptor with RNA Damaging Agents
4 The Development of Liposomes for Enhanced Delivery of Chemotherapeutics to Tumors
5 Overcoming Multiple Drug Resistance with Anti-Pgn Carrier
6 Targeting with Transferrin
7 Synthesis and Evaluation of Paclitaxel Immunoconjugate with Antitumor Activity In Vitro
8 The Use of Drug-Monoclonal Antibody Conjugates for the Treatment of Cancer

III. Targeting Tumors with Antibodies
9 Targeting Vascular Endothelium with Antibodies
10 Targeting B-Cell Non-Hodgkin’s Lymphoma with Monoclonal Antibodies
11 From Bench to Bedside: Development of Rituximab (Rituxan®), A Monoclonal Antibody for the Therapy of Non-Hodgkin’s Lymphoma
12 Mylotarg: The First Antibody-Targeted Chemotherapy Agent

IV. Targeting Tumors with Radioimmunoconjugates
13 188Rhenium-Labeled Trisuccin-?CH2HuCC49 as a Radioimmunotherapy Model in Nude Mice

V. Targeting Tumors with Immunotoxins
14 General Approach for Targeting Toxins
15 Antibody-Toxin Conjugates: Chemistry of Coupling and Purification
16 Shiga-Like Toxins as Targeted Anticancer Agents

VI. Targeting Tumors with Antibody-Enzyme Conjugates (ADEPT)
17 Antibody-Directed Enzyme Prodrug Therapy with Carboxypeptidase G2: Clinical Studies

VII. Photodynamic Therapy
18 Photodynamic Therapy: Targeting Cancer Cells with Photosensitizer-Bioconjugates
19 Tumor Targeting Using PEG-m-THPC for Photodynamic Therapy in a Rat Ovarian-Cancer Model

VIII. Targeting Tumors with Magnetic Drugs
20 Targeting Tumors with Magnetic Drugs

IX. Principles and Techniques in Targeting
21 Internalization of Antibodies
22 Bioconjugation and Biodistribution
23 Principles of Antitumor Targeting of Cytotoxic Drugs
24 Targeting by Antibody or Ligand: Which Is Better?

 

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Tags: Michel Pagé, Tumor, Targeting, Cancer