Catalytic Antibodies 1st Edition by Ehud Keinan 9783527605057 3527605053

Exploiting the inherent combinatorial mechanism in the biosynthesis of antibodies, an almost limitless variety of biocatalysts may be generated. Catalytic antibodies are capable of performing almost any type of reaction with high selectivity and stereospecificity.
Here, the pioneers in the use of catalytic antibodies review the entire scope of this interdisciplinary field, covering such topics as:
* theoretical aspects of structure, mechanism and kinetics
* practical considerations, from immunization techniques to screening methods
* in vitro evolution and other modern approaches
* applications from organic synthesis to medical uses.
Backed by the leading authorities in antibody catalysis, this is the first book to provide such comprehensive coverage and constitutes a prime reference for biochemists, organic chemists, biotechnologists and biomedical researchers.

Table of contents:

Chapter 1: Immunological Evolution of Catalysis

Chapter 2: Critical Analysis of Antibody Catalysis

Chapter 3: Theoretical Studies of Antibody Catalysis

Chapter 4: The Enterprise of Catalytic Antibodies: A Historical Perspective

Chapter 5: Catalytic Antibodies in Natural Products Synthesis

Chapter 6: Structure and Function of Catalytic Antibodies

Chapter 7: Antibody Catalysis of Disfavored Chemical Reactions

Chapter 8: Screening Methods for Catalytic Antibodies

Chapter 9: In vitro Evolution of Catalytic Antibodies and Other Proteins via Combinatorial Libraries

Chapter 10: Medicinal Potential of Catalytic Antibodies

Chapter 11: Reactive Immunization: A Unique Approach to Aldolase Antibodies

Chapter 12: The Antibody-Catalyzed Water Oxidation Pathway

Chapter 13: Photoenzymes and Photoabzymes

Chapter 14: Selectivity with Catalytic Antibodies – What Can Be Achieved?

Chapter 15: Catalytic Antibodies as Mechanistic and Structural Models of Hydrolytic Enzymes

Chapter 16: Transition State Analogs – Archetype Antigens for Catalytic Antibody Generation

Chapter 17: Polyclonal Catalytic Antibodies

Chapter 18: Production of Monoclonal Catalytic Antibodies: Principles and Practice

Chapter 19 Natural Catalytic Antibodies – Abzymes