Targeted Delivery of Small and Macromolecular Drugs 1st edition by Ajit S Narang, Ram I Mahato ISBN 1138114510 978-1138114517

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ISBN 10: 1138114510

ISBN 13:  978-1138114517

Author: Ajit S Narang, Ram I Mahato 

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice.

Focusing on the delivery technologies that utilize both systemic and local routes of administration, Targeted Delivery of Small and Macromolecular Drugs brings together field experts who summarize current progress and discuss novel ideas currently being explored to overcome these challenges.

Targeted Delivery of Small and Macromolecular Drugs 1st Table of contents:

Introduction

• Overview of Drug Delivery Systems

• Importance of Targeted Drug Delivery

• The Challenge of Delivering Small and Macromolecular Drugs Effectively

• Structure and Goals of the Book

Part I: Basic Principles of Drug Delivery

1. Fundamentals of Drug Delivery

   • Drug Delivery Routes: Oral, Parenteral, Topical, and More

   • Key Concepts: Absorption, Distribution, Metabolism, Excretion (ADME)

   • Bioavailability and Pharmacokinetics in Drug Delivery

2. Types of Drugs: Small Molecules vs. Macromolecules

   • Characteristics of Small Molecules: Synthesis, Stability, and Solubility

   • Characteristics of Macromolecules: Proteins, Peptides, and Nucleic Acids

   • Differences in Delivery Challenges for Small and Large Drugs

3. Barriers to Effective Drug Delivery

   • Biological Barriers: Cell Membranes, Blood-Brain Barrier, Organs, and Tissues

   • Biochemical Barriers: Enzyme Degradation and Immune Response

   • Physical Barriers: Tissue Penetration and Retention

Part II: Mechanisms of Targeted Drug Delivery

4. Principles of Targeted Drug Delivery

   • Targeting by Receptor-Mediated Endocytosis

   • Antibody-Drug Conjugates (ADCs) and Targeted Monoclonal Antibodies

   • Nanoparticles for Drug Delivery: Liposomes, Dendrimers, and Polymeric Nanoparticles

5. Targeting Strategies for Small Molecules

   • Targeting Specific Receptors and Enzymes

   • Prodrugs and Enzyme-Sensitive Drug Systems

   • Active vs. Passive Targeting Methods

6. Targeting Strategies for Macromolecules

   • Peptide and Protein-Based Drug Delivery Systems

   • Nucleic Acid Delivery: siRNA, mRNA, and Gene Therapy

   • Challenges in Protein and Nucleic Acid Stability, Delivery, and Cellular Uptake

Part III: Technologies in Targeted Drug Delivery

7. Nanotechnology in Targeted Drug Delivery

   • Nanocarriers for Controlled Release: Liposomes, Micelles, and Nanoparticles

   • Surface Modifications for Targeting Specific Cells and Tissues

   • Overcoming Biological Barriers with Nanotechnology

8. Biopolymer-Based Drug Delivery Systems

   • Polymers for Drug Encapsulation and Controlled Release

   • Stimuli-Responsive Polymers and Smart Drug Delivery Systems

   • Biodegradable Polymers and Their Applications in Medicine

9. Gene Delivery Systems

   • Viral and Non-Viral Vectors for Gene Therapy

   • Advances in DNA and RNA Delivery Systems

   • Targeted Gene Editing and CRISPR-Cas Technology

Part IV: Clinical Applications and Challenges

10. Targeted Delivery in Cancer Therapy

    • Tumor-Targeted Drug Delivery: Strategies and Technologies

    • Chemotherapy and Immunotherapy: Enhancing Selectivity and Reducing Toxicity

    • Clinical Successes and Ongoing Challenges in Targeted Cancer Therapies

11. Targeted Delivery in Neurological Disorders

    • Blood-Brain Barrier and Strategies for Crossing It

    • Targeted Drug Delivery in Alzheimer’s, Parkinson’s, and Other CNS Diseases

    • Nanoparticles and Other Technologies for Brain Targeting

12. Targeted Delivery in Infectious Diseases

    • Targeting Pathogens with Small Molecules and Antimicrobial Peptides

    • Nanoparticles for Targeting Viral and Bacterial Infections

    • Challenges in Targeting Infections in Specific Tissues and Organs

13. Targeted Delivery in Autoimmune and Inflammatory Diseases

    • Targeting Immune Cells and Inflammation Sites

    • Drug Delivery Systems for Rheumatoid Arthritis, Inflammatory Bowel Disease, and More

    • Challenges in Immune System Targeting and Drug Efficacy

Part V: Future Directions and Innovations

14. Emerging Technologies in Drug Delivery

    • Artificial Intelligence and Machine Learning in Drug Development

    • Personalized Medicine and Targeted Therapy

    • Innovations in Drug Carriers: Micro and Nanostructures

15. Challenges and Opportunities in Targeted Drug Delivery

    • Overcoming the Challenges of Toxicity and Drug Resistance

    • Regulatory and Ethical Issues in Drug Delivery Systems

    • Future Trends in Drug Delivery Technologies

Conclusion

• Summary of Key Concepts and Technologies in Targeted Drug Delivery

• The Role of Targeted Drug Delivery in the Future of Medicine

• Final Thoughts on Improving Patient Outcomes Through Better Drug Delivery

Appendices

• Appendix A: List of Common Drug Delivery Systems and Technologies

• Appendix B: Drug Delivery Materials and Carrier Systems

• Appendix C: Glossary of Terms in Drug Delivery

• Index

 

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Ajit S Narang,Ram I Mahato,Targeted Delivery,Macromolecular Drugs