The Handbook of Metabonomics and Metabolomics 1st Edition by John Lindon, Jeremy Nicholson, Elaine Holmes 0444528415 9780444528414
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Product details:
ISBN 10: 0444528415
ISBN 13: 9780444528414
Author: John C. Lindon, Jeremy K. Nicholson, Elaine Holmes
Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These “omics” methods form the basis for understanding biology at a systems level.
The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.
* comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies
* aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification
* covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.
Table of contents:
Chapter 1: Metabonomics and Metabolomics Techniques and Their Applications in Mammalian Systems
Chapter 2: Cellular Metabolomics: The Quest for Pathway Structure
Chapter 3: NMR Spectroscopy Techniques for Application to Metabonomics
Chapter 4: High-Resolution Magic Angle Spinning NMR Spectroscopy
Chapter 5: Chromatographic and Electrophoretic Separations Combined with Mass Spectrometry for Metabonomics
Chapter 6: Chemometrics Techniques for Metabonomics
Chapter 7: Non-linear Methods for the Analysis of Metabolic Profiles
Chapter 8: Databases and Standardisation of Reporting Methods for Metabolic Studies
Chapter 9: Metabonomics in Preclinical Pharmaceutical Discovery and Development
Chapter 10: Applications of Metabonomics in Clinical Pharmaceutical R&D
Chapter 11: Exploiting the Potential of Metabonomics in Large Population Studies: Three Venues
Chapter 12: Metabolite Profiling and Cardiovascular Disease
Chapter 13: The Role of NMR-based Metabolomics in Cancer
Chapter 14: NMR Spectroscopy of Body Fluids as a Metabolomics Approach to Inborn Errors of Metabolism
Chapter 15: A Survey of Metabonomics Approaches for Disease Characterisation
Chapter 16: Metabolic Profiling: Applications in Plant Science
Chapter 17: In vivo NMR Applications of Metabonomics
Chapter 18: Applications of Metabonomics Within Environmental Toxicology
Chapter 19: Global Systems Biology Through Integration of “Omics” Results
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