Advances in Cancer Research Clusterin Part B 1st Edition by Saverio Bettuzzi, Sabina Pucci ISBN 0123814294, 9780123814302
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ISBN 10: 0123814294
ISBN 13: 9780123814302
Author: Saverio Bettuzzi, Sabina Pucci
Advances in Cancer Research: Clusterin, Part B 1st Edition: d
Advances in Cancer Research: Clusterin, Part B 1st Edition Table of contents:
Clusterin (CLU) and Prostate Cancer
I. Introduction
II. Briefly About Clinically Relevant Human PCa
III. CLU Signaling in Normal and Transformed Cell Lines
IV. CLU Expression in Human PCa
V. Castration Resistant and Metastatic PCa: The Challenge of CLU Antisense Therapy
VI. Chemoprevention of PCa: A Role for CLU in the Mechanism of Action of GTCs
VII. CLU as Tumor Modulator: Is CLU a Novel Tumor Suppressor Gene?
VIII. Conclusions
Acknowledgments
The Role of Clusterin (CLU) in Malignant Transformation and Drug Resistance in Breast Carcinomas
Abbreviations
I. Introduction
II. Localization of CLU in Breast Carcinomas
III. Relationship Between Cytoplasmic CLU and Apoptosis in Breast Carcinomas
IV. Role of CLU in Tumorigenesis and Progression of Breast Carcinomas
V. Prognostic Significance of CLU Expression in Breast Carcinomas
VI. CLU and Resistance to Treatment in Breast Carcinomas
VII. Conclusions
Acknowledgments
CLU and Colon Cancer: The Dual Face of CLU
I. Introduction: Genes and Proteins in Colorectal Cancer
II. Genetic Instability and Control of DNA Damage: DNA Double-Strand Breaks Repair
III. Clonal Expansion: Apoptosis Inhibition
IV. CLU in Colorectal Cancer Progression: sCLU and Apoptosis Escape
V. CLU as a New Biomarker for Colon Cancer Screening
VI. Conclusions and Future Perspectives
Clusterin (CLU) and Lung Cancer
I. Introduction
II. Carcinogenesis
III. Progression/Metastasis
IV. Treatment
V. CLU Expression and Prognosis in Patients with Lung Cancer
VI. Conclusions
Acknowledgments
Clusterin and Chemoresistance
I. Introduction
II. Association of sCLU with Chemoresistance
III. Association of sCLU with Multidrug Resistance
IV. Association of sCLU with Resistance to Irradiation and Oxidative Stress
V. Association of sCLU with Progressive Tumors
VI. Association of sCLU with Resistance to Targeted Therapy (TNF, FAS, TRAIL, HDAC Inhibitors, Herceptin)
VII. Induction by Genotoxic and Oxidative Stresses
VIII. Mechanism of Induction of and Cytoprotection by CLU
IX. Strategies to Blockade CLU for Chemosensitization in Cancer Cells
CLU “In and Out”
I. Introduction
II. Normal and Cancer Microecosystem
III. Microenvironment Effects on CLU Expression (the “IN” Effect)
IV. sCLU Effects on Microenvironment (the “OUT” Effect): Up- and Downstream Signals
V. Conclusions and Future Perspectives
Regulation of CLU Gene Expression by Oncogenes and Epigenetic Factors
I. Introduction
II. Regulation of CLU Expression by Transforming Oncogenes: Early Evidence
III. Regulation of CLU Expression by Protooncogenic Transcription Factors
IV. Oncogenic Signaling and Epigenetic Regulation of CLU Expression
V. Concluding Remarks
Acknowledgments
Conclusions and Perspectives
I. Introduction
II. Take Home Messages from Chapters of Vols. 104 and 105
III. General Consensus
IV. Open Issues
V. Possible Clinical Implementations
VI. Future Research
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