Advances in Immunology Vol 97 1st Edition by Frederick Alt 0123743249 9780123743244

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ISBN 10: 0123743249 

ISBN 13: 9780123743244

Author: Frederick W. Alt

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of contents:

Chapter 1: T Cell Activation and the Cytoskeleton: You Can’t Have One Without the Other
1. Introduction
2. TCR Signaling Leading to Actin Cytoskeletal Remodeling
3. Cytoskeletal Control of IS Formation
4. Regulation of TCR-Mediated MTOC Polarization
5. F-Actin-Mediated Regulation of Integrins
6. Cytoskeletal Dynamics and Cell Migration
7. Conclusion
References
Chapter 2: HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases
1. Introduction
2. Expression and Function of HLA-DQ Transgenes in Mice
3. HLA-DQ Transgenic Mice as Models for Human Allergies
4. Expression and Function of HLA-DR Transgenic Mice
5. HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis-Derived Proteins a
6. Collagen-Induced Arthritis-Model for Human Rheumatoid Arthritis
7. Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis
8. Spontaneous Models for Human Type I Diabetes
9. Experimental Autoimmune Myasthenia Gravis
10. HLA and Gluten Sensitivity-Celiac Disease and Dermatitis Herpetiformis
11. Relapsing Polychondritis
12. Spontaneous Autoimmune Myocarditis
13. Experimental Autoimmune Thyroiditis
14. Experimental Autoimmune Uveitis
15. Bacterial Superantigens and Toxic Shock Syndrome
16. Concluding Remarks
References
Chapter 3: Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule
1. Introduction
2. Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease
3. Role of Zn in the Immune Response
4. Role of Zn in Mast Cells
5. Zn Signaling
6. Conclusion and Future Prospects
Acknowledgements
References
Chapter 4: The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses
1. Introduction
2. Structure, Ligands, and Expression of the SLAM-Family Receptors
3. The SLAM-Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Sy
4. The SLAM-Associated Protein
5. The Protective Role of SAP in X-Linked Lympho-Proliferative Disease
6. The SAP-Related Single SH2-Domain Proteins EAT-2A and EAT-2B
7. The SLAM-Family Receptors in NK Cell Responses
8. The Role of the SLAM-Family in Lymphoid Cells
9. The Role of the SLAM-Family on Nonlymphoid Cells
10. Concluding Remarks
References
Chapter 5: Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lym
1. Introduction
2. A Minimal Signaling Kit Couples to Proximal Transducer Enzymes
3. Signal Initiation: BCR Clusters with an Open Conformation
4. SLP-65: A Gateway to Intracellular Signaling Pathways
5. Dynamic Regulation of the BCR-Triggered Ca2+ Response
6. Mechanism and Function of BCR-Induced Ras Activation
7. Concluding Remarks
References

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