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Advances in the Diagnosis of Coronary Atherosclerosis 1st Edition by Suna F Kirac ISBN 9533072865 9789533072869

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Advances in the Diagnosis of Coronary Atherosclerosis 1st Edition Edition Suna F. Kiraç Digital Instant Download

Author(s): Suna F. Kiraç
ISBN(s): 9789533072869, 9533072865
Edition: 1st Edition
File Details: PDF, 29.44 MB
Year: 2011
Language: english
SKU: EB-2346062 Category: Tag:

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ISBN 10: 9533072865 
ISBN 13: 9789533072869
Author: Suna F Kirac

Coronary artery disease (CAD) and its consequences are most important morbidity and mortality reasons in the developed and developing countries. To prevent hard end-points, early definitive diagnosis and optimum therapy play significant role. Novel advanced diagnostic tests which are biomarkers of inflammation, cell adhesion, cell activation and imaging techniques provide to get the best result in the detection and characterization of calcified or uncalcified atherosclerotic plaques. In spite of last developments in the imaging methods, coronary catheterization is still frequently performed. Following the first cardiac catheterization performed in 1844, date by date historical developments and the mechanics of cardiac catheterization techniques, risks associated with coronary angiography, and also, preventions and treatments of possible complications have been presented in this book. Other important issue is radiation exposure of patients and staff during coronary angiography and scintigraphy. Radiation dose reduction techniques, general radiation protection principles have been discussed in related chapters.

Advances in the Diagnosis of Coronary Atherosclerosis 1st Table of contents:

Part I: Fundamentals and Traditional Diagnostic Approaches

  • Chapter 1: Pathophysiology of Coronary Atherosclerosis
    • Initiation and Progression of Atherosclerotic Plaques
    • Inflammation and Endothelial Dysfunction
    • Plaque Morphology and Vulnerability
    • Clinical Manifestations of Coronary Artery Disease
  • Chapter 2: Clinical Assessment and Risk Stratification
    • Patient History and Physical Examination
    • Traditional Risk Factors (Hypertension, Dyslipidemia, Diabetes, Smoking)
    • Risk Scores and Guidelines (e.g., Framingham, ASCVD Risk Estimator)
    • Biomarkers of Cardiovascular Risk (e.g., hs-CRP, Lp(a))
  • Chapter 3: Electrocardiography (ECG) in Coronary Atherosclerosis
    • Resting ECG Findings (Ischemia, Infarction)
    • Exercise ECG (Stress Testing) Principles and Interpretation
    • Limitations and Clinical Utility
  • Chapter 4: Cardiac Stress Testing (Beyond ECG)
    • Stress Echocardiography (Dobutamine, Exercise)
    • Myocardial Perfusion Imaging (SPECT, PET)
    • Pharmacological Stress Agents
    • Diagnostic Accuracy and Prognostic Value

Part II: Advanced Imaging Modalities for Anatomical and Functional Assessment

  • Chapter 5: Coronary Angiography (CA): The Gold Standard and Its Evolution
    • Principles of Invasive Angiography
    • Indications and Contraindications
    • Limitations of Luminal Assessment
    • Quantitative Coronary Angiography (QCA)
  • Chapter 6: Cardiac Computed Tomography Angiography (CCTA)
    • Technical Principles and Scanner Generations
    • Coronary Artery Calcium (CAC) Scoring
    • Diagnosis of Stenosis and Plaque Characterization
    • CT-Derived Fractional Flow Reserve (FFR-CT)
    • Clinical Applications and Future Directions
  • Chapter 7: Cardiac Magnetic Resonance Imaging (CMR) in Atherosclerosis
    • CMR for Myocardial Ischemia (Stress Perfusion CMR)
    • CMR for Myocardial Viability and Scar
    • CMR for Plaque Imaging and Characterization
    • Advantages and Challenges of CMR
  • Chapter 8: Intravascular Ultrasound (IVUS)
    • Principles and Techniques of IVUS
    • Assessment of Plaque Burden, Composition, and Morphology
    • Clinical Utility in Guiding Intervention
    • Limitations and Role in Current Practice
  • Chapter 9: Optical Coherence Tomography (OCT)
    • High-Resolution Imaging of the Vessel Wall
    • Detailed Plaque Characterization (Fibrous Cap, Lipid Pool, Thrombus)
    • Identification of Vulnerable Plaques
    • Comparison with IVUS and Clinical Applications

Part III: Emerging Technologies and Future Perspectives

  • Chapter 10: Positron Emission Tomography (PET) in Coronary Atherosclerosis
    • Molecular Imaging of Inflammation and Metabolic Activity
    • Tracers for Plaque Imaging (e.g., FDG-PET)
    • Quantitative Myocardial Blood Flow (MBF) Assessment
    • Research Applications and Clinical Potential
  • Chapter 11: Artificial Intelligence and Machine Learning in Diagnosis
    • Applications in Image Analysis (CCTA, CMR, IVUS/OCT)
    • Predictive Modeling for Risk Stratification
    • Automation of Diagnostic Workflow
    • Challenges and Ethical Considerations
  • Chapter 12: Blood-Based Biomarkers for Atherosclerosis and Plaque Vulnerability
    • Novel Inflammatory Biomarkers
    • Biomarkers of Oxidative Stress and Endothelial Dysfunction
    • MicroRNAs and Circulating Cell-Free DNA
    • Integrated Biomarker Panels
  • Chapter 13: Non-Invasive Flow Assessment (Beyond FFR-CT)
    • Myocardial Perfusion Quantification with CMR and PET
    • Doppler Echocardiography for Coronary Flow Reserve
    • Emerging Techniques for Functional Assessment
  • Chapter 14: Integrated Diagnostic Pathways and Personalized Medicine
    • Combining Multiple Modalities for Comprehensive Assessment
    • Role of Multi-Modality Heart Teams
    • Tailoring Diagnostic Strategies to Individual Patients
    • Future Directions in Early Detection and Prevention

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