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Advances in Vasopressin and Oxytocin From Genes to Behaviour to Disease 1st Edition by Inga Neumann, Rainer Landgraf 9780444532015 0444532013

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Advances in Vasopressin and Oxytocin From Genes to Behaviour to Disease 1st Edition Inga D. Neumann And Rainer Landgraf (Eds.) Digital Instant Download

Author(s): Inga D. Neumann and Rainer Landgraf (Eds.)
ISBN(s): 9780444532015, 0444532013
Edition: 1
File Details: PDF, 21.55 MB
Year: 2008
Language: english
SKU: EB-4548842 Category: Tag:

Advances in Vasopressin and Oxytocin From Genes to Behaviour to Disease 1st Edition by Inga Neumann, Rainer Landgraf – Ebook PDF Instant Download/Delivery: 9780444532015, 0444532013

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Product details:

ISBN 10: 0444532013

ISBN 13: 9780444532015

Author: Inga D. Neumann, Rainer Landgraf

Vasopressin and oxytocin are the key hormones of the hypothalamo-neurohypophysial system, and are well-known to be critically involved in antidiuresis, labor, and milk ejection. This book highlights the latest research on vasopressin and oxytocin, covering multiple biological aspects. The capacity of both hormones to regulate various aspects of social behaviours including pair-bonding, aggression, maternal love, and sexual behaviour, is a main focus, as are their interactions with a variety of other neuromodulators and transmitters. Moreover, the book illustrates the recent development of vasopressin and oxytocin agonists/antagonists as potential drugs to treat not only disturbances of body fluid homeostasis, but also mental disorders, including social phobia, autism, anxiety, and depression. The promising combination of basic and clinical research, comprising physiology, neuroendocrinology, behavioral biology, pharmacology, imaging and molecular genetics makes this book an essential addition to both experts and scientists new to the field alike.

• Comprehensive review of OXT and AVP physiology and behaviour
• Each chapter covers a novel aspect of OXT and AVP research and is written by a leading expert
• Review articles are ideal for experts and newcomers to the field alike
• Discusses fascinating behavioural effects of oxytocin and vasopressin
• Summarizes the recent explosion of neuropeptide research, physiology and behaviour, is in one location

Table of contents:

Section I. Vasopressin and Oxytocin in Evolution, Sexual Dichotomy and Stress

  1. Nonapeptides and the Evolutionary Patterning of Sociality

  2. Sex Differences in Vasopressin and Oxytocin Innervation of the Brain

  3. The Parvocellular Vasopressinergic System and Responsiveness of the Hypothalamic Pituitary

Section II. Genetics Meets Behaviour

  1. Experimental Approaches for the Study of Oxytocin and Vasopressin Gene Expression

  2. Oxytocin Knockout Mice: A Model for Studying Stress-related and Ingestive Behaviours

  3. The Role of the Vasopressin 1b Receptor in Aggression and Other Social Behaviours

  4. Behavioural Studies Using Temporal and Spatial Inactivation of the Oxytocin Receptor

  5. New Aspects of Oxytocin Receptor Function Revealed by Knockout Mice: Sociosexual Behaviour

Section III. Regulation of Vasopressin and Oxytocin Release

  1. Regulation of Vasopressin Release by Co-released Neurotransmitters

  2. Neuron-Glia Interactions in the Rat Supraoptic Nucleus

  3. Dynamic Synapses in the Hypothalamic-Neurohypophyseal System

  4. Endogenous Modulators of Synaptic Transmission: Cannabinoid Regulation

  5. Oxytocin and Appetite

Section IV. Nonapeptide Receptors: Regulation and Signalling

  1. Neural Mechanisms Underlying the Milk Ejection Burst and Reflex

  2. Oxytocin Receptor Signalling

  3. Neurosteroids Are Excitatory in Supraoptic Neurons but Inhibitory in the Peripheral Nervous System

  4. Oxytocin Receptors: Ligand Binding, Signalling and Cholesterol Dependence

Section V. Neuronal Actions of Nonapeptides

  1. Opposite Effects of Oxytocin and Vasopressin on the Emotional Expression of Fear

  2. Multi-Factorial Somato-Dendritic Regulation of Phasic Spike Discharge in Vasopressin Neurons

  3. Neurophysiology of Supraoptic Neurons in C57/BL Mice

  4. Effects of Oxytocin on GABA Signalling in the Foetal Brain During Delivery

Section VI. Regulation of Social Behaviours

  1. Central Vasopressin and Oxytocin Release: Regulation of Complex Social Behaviours

  2. Interactions Between Dopamine and Oxytocin in the Control of Sexual Behaviour

  3. Steroidal/Neuropeptide Interactions Related to Social Anxiety

  4. Functional Magnetic Resonance Imaging and the Neurobiology of Vasopressin and Oxytocin

  5. Evolution of the Arginine Vasopressin 1a Receptor and Implications for Mammalian Social Behaviour

  6. Oxytocin, Vasopressin and Sociality

  7. Neuropeptides and Social Behaviour: Effects of Oxytocin and Vasopressin in Humans

Section VII. Oxytocin and Vasopressin: Involvement in Stress Management

  1. Chronic Stress Plasticity in the Hypothalamic Paraventricular Nucleus

  2. Keeping Oxytocin Neurons Under Control During Stress in Pregnancy

  3. Rapid Synapse-Specific Regulation of Hypothalamic Magnocellular Neurons by Glucocorticoids

  4. Vasopressin in the Septum: Not Important Versus Causally Involved in Learning and Memory

  5. Role of the Endocannabinoid System in Regulation of the HPA Axis

Section VIII. Psychopathology: Critical Involvement of the Vasopressin and Oxytocin Systems

  1. Molecular Genetic Studies of the AVPR1a and Oxytocin Receptors

  2. Oxytocin and Experimental Therapeutics in Autism Spectrum Disorders

  3. Impact of Prosocial Neuropeptides on Human Brain Function

Section IX. Vasopressin and Oxytocin Agonists and Antagonists: From Pharmacology to Clinical Utility

  1. Peptide and Non-Peptide Agonists and Antagonists for Vasopressin and Oxytocin Receptors

  2. Affinity and Efficacy of Selective Agonists and Antagonists

  3. Prevention of Hypoxic Brain Oedema by Vasopressin Receptor Antagonists

  4. Characterization of a Novel and Selective V1B Receptor Antagonist

Section X. Physiology and Pathophysiology of Renal Actions of Vasopressin

  1. Molecular Mechanisms of Clinical Concentrating and Diluting Disorders

  2. Actin-Binding Channels

  3. Opposite Potentiality of Coexpressed Neuropeptides, Apelin and Vasopressin

  4. Recent Discoveries in Vasopressin-Regulated Aquaporin-2 Trafficking

  5. Pathophysiological Role of Aquaporin-2 in Impaired Water Excretion

  6. Potential Utility of Aquaporin Modulators for Therapy of Brain Disorders

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Tags: Inga Neumann, Rainer Landgraf, Advances, Oxytocin