Animal Models of Human Inflammatory Skin Diseases 1st Edition by Lawrence Chan 0849313910 9780849313912

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ISBN 10: 0849313910

ISBN 13: 9780849313912

Author: Lawrence S. Chan

Progress in understanding skin diseases has been aided enormously by the use of tissues derived from animals, by studying normal processes in animals, and by the development of animal models. The cellular activities in animals and humans are remarkably similar and the actual pathological process of an inflammatory skin disease can only be accurately observed and analyzed in a living animal model, and not in any in vitro model system. These factors have led to the regular use of animal tissues and models to allow the disease processes to be studied at a much greater depth.

Animal Models of Human Inflammatory Skin Diseases features the principles and practices of how to go about studying inflammatory skin diseases using live animal models. On the principle side, the book describes the comparative structure and function of the skin, and the comparative immunology system in animal species commonly used as models. From the practical perspective, it presents a general discussion on methods of experimental animal modeling and contains specific expert experience on individual models. The authors include a detailed method of disease induction for each model, present chapters on comparative histology and immunology, and discuss potential targets of disease intervention.

Written by biomedical investigators with first-hand experience in their chosen fields, this book is a valuable guide and reference for investigators in the biomedical and pharmaceutical sciences.
It provides an instantaneous comparison between the skin structure and immunology of humans and animals, aiding in the interpretation and application of pathologic and immunologic findings.

Animal Models of Human Inflammatory Skin Diseases 1st Table of contents:

PART I: Comparative Structure and Function of the Skin

Chapter 1: Comparative Structure and Function of the Skin: Overview of Structures and Components

Chapter 2: Comparative Structure and Function of the Skin: Epithelial Basement Membrane Zone

PART II: Comparative Immunology

Chapter 3: Human Immune System

Chapter 4: Canine Immune System

Chapter 5: Rat Immune System

Chapter 6: Mouse Immune System

Chapter III: Immune Privilege and Skin Inflammation

Chapter 7: Immune Privilege of the Eye

Chapter 8: The Theory of Immune Privilege of the Hair Follicle

Chapter IV: Methods of Experimental Animal Modeling

Chapter 9: Passive Transfer and Active Induction of Autoimmune Diseases

Chapter ABC

Chapter 10: Adoptive Transfer of Cellular Immunity

Chapter 11: Molecular Biological Manipulation of the Immune System by Transgenic Techniques

Chapter V: Inflammatory Skin Disease Models

Chapter A: Bullous Pemphigoid

Chapter 12: Natural Bullous Pemphigoid in Companion Animals

Chapter 13: Experimental Mouse Model of Bullous Pemphigoid: Passive Transfer of Anti-BP180 Type XVII Collagen, Antibodies

Chapter B: Epidermolysis Bullosa Acquisita

Chapter 14: Spontaneous Canine Model of Epidermolysis Bullosa Acquisita

Chapter C: Mucous Membrane Pemphigoid

Chapter 15: Spontaneous Canine Model of Mucous Membrane Pemphigoid

Chapter 16: Experimental Mouse Model of Mucous Membrane Pemphigoid: Passive Transfer of Anti-Laminin 5 Antibodies

Chapter D: Pemphigus Vulgaris

Chapter 17: Spontaneous Canine Model of Pemphigus Vulgaris

Chapter 18: Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Desmoglein-Targeting Antibodies

Chapter 19: Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Nondesmoglein 1 and 3 Antibodies

Chapter E: Pemphigus Foliaceus

Chapter 20: Spontaneous Canine Model of Pemphigus Foliaceus

Chapter 21: Experimental Mouse Model of Pemphigus Foliaceus: Passive Transfer of Desmoglein-Targeting Antibodies

Chapter F: Psoriasis

Chapter 22: Experimental Chimeric SCID Mouse/Human Skin Model of Psoriasis: Induction by Transfer of Cellular Immunity

Chapter 23: Experimental Mouse Model of Psoriasis by Transgenic Expression of Integrin

Chapter G: Atopic Dermatitis

Chapter 24: Spontaneous Canine Model of Atopic Dermatitis

Chapter 25: Spontaneous Mouse Model of Atopic Dermatitis in NC/Nga Mice

Chapter 26: Experimental Mouse Model of Atopic Dermatitis by Transgenic Induction

Chapter 27: Experimental Mouse Model of Atopic Dermatitis: Induction by Oral Allergen

Chapter 28: Experimental Mouse Model of Atopic Dermatitis: Induction by Epicutaneous Application of Allergen

Chapter H: Alopecia Areata

Chapter 29: Spontaneous and Experimental Skin-Graft-Transfer Mouse Models of Alopecia Areata

Chapter 30: Spontaneous Rat Model of Alopecia Areata in the Dundee Experimental Bald Rat (DEBR)

Chapter 31: Spontaneous Canine Model of Alopecia Areata

Chapter IRS Hb Hb a b

Chapter 32: Experimental Chimeric SCID Mouse/Human Skin Model of Alopecia Areata: Induction by Transfer of Cellular Immunity

Chapter I: Scleroderma

Chapter 33: Spontaneous Mouse Models of Systemic Scleroderma

Chapter 34: Experimental Mouse Model of Scleroderma/Graft versus Host Disease: Induction by Transfer of Cellular Immunity

Chapter 35: Experimental Mouse Model of Scleroderma: Induction by Bleomycin

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