Anticancer Therapeutics 1st Edition by Sotiris Missailidis ISBN 0470723033 9780470723036

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ISBN 10: 0470723033 
ISBN 13: 9780470723036
Author: Sotiris Missailidis

This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment.

Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow.

The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design.

Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.

Anticancer Therapeutics 1st Table of contents:

SECTION I: Drug Discovery and Design

• 1. Exploring the Potential of Natural Products in Cancer Treatment

  • Fotini N. Lamari and Paul Cordopatis

  • 1.1 Introduction

  • 1.2 Sources

  • 1.3 Different Approaches to the Search for Bioactive Natural Products

  • 1.4 Methodologies of Lead Compound or New Drug Identification

  • 1.5 Chemoprevention – A New Area for Natural Product Research

  • 1.6 Concluding Remarks

• 2. Combinatorial Approaches to Anticancer Drug Design

  • Sotiris Missailidis

  • 2.1 Introduction

  • 2.2 Combinatorial Approaches for Small Molecule Drug Design

  • 2.3 Display Technologies

  • 2.4 Aptamer Selection

  • 2.5 Conclusions

• 3. Rational Approaches to Anticancer Drug Design/in silico Drug Development

  • Stefano Alcaro, Anna Artese, and Francesco Ortuso

  • 3.1 Introduction

  • 3.2 Approaches to the Drug Discovery Process in Anticancer Research

  • 3.3 Ligand-based Examples

  • 3.4 Structure-based Examples

  • 3.5 Conclusions

SECTION II: Anticancer Therapeutics

• 4. Introduction to Anticancer Therapeutics

  • Teni Boulikas

  • 4.1 Problems in Cancer

  • 4.2 Cancer Treatments

  • 4.3 Classification of Chemotherapy Drugs

• 5. Platinum Drugs

  • Teni Boulikas, Alexandros Pantos, Evagelos Bellis, and Petros Christofis

  • 5.1 Cisplatin

  • 5.2 Lipoplatin™

  • 5.3 Carboplatin

  • 5.4 Oxaliplatin

  • 5.5 Lipoxal

  • 5.6 New Platinum Compounds

  • 5.7 Cisplatin Resistance and Chemotherapy

• 6. Antimicrotubule Agents

  • Iain Brown, Jay N. Sangrithi-Wallace, and Andrew C. Schofield

  • 6.1 Taxanes

  • 6.2 Vinca Alkaloids

  • 6.3 Mechanisms of Resistance to Antimicrotubule Agents

• 7. Antimetabolites in Cancer Therapy

  • Jessica Scaife and David Kerr

  • 7.1 Introduction

  • 7.2 Folate Antagonists

  • 7.3 Pyrimidine Antagonists

  • 7.4 Purine Antagonists

  • 7.5 Summary

• 8. Antitumour Antibiotics

  • Manuel M. Paz

  • 8.1 Introduction

  • 8.2 Actinomycin

  • 8.3 Mitomycin C

  • 8.4 Bleomycin

  • 8.5 Anthracyclines

  • 8.6 Trabectedin (Ecteinascidin, ET-743)

  • 8.7 Camptothecins

  • 8.8 Podophyllotoxins

• 9. Alkylating Agents

  • Ana Paula Francisco, Maria de Jesus Perry, Rui Moreira, and Eduarda Mendes

  • 9.1 Introduction

  • 9.2 Nitrogen Mustards

  • 9.3 Methylmelamines and Ethylenimines

  • 9.4 Methylhydrazine Derivatives

  • 9.5 Alkylsulfonates

  • 9.6 Nitrosoureas

  • 9.7 Triazenes

• 10. Hormone Therapies

  • George C. Zografos, Nikolaos V. Michalopoulos, and Flora Zagouri

  • 10.1 Introduction

  • 10.2 Oestrogen Receptor Targeted Therapeutics

  • 10.3 Progesterone-Targeted Therapy

  • 10.4 Neuroendocrine Tumours

• 11. Photodynamic Therapy of Cancer

  • K. Eszter Borbas and Dorothée Lahaye

  • 11.1 Introduction

  • 11.2 Photosensitizers

  • 11.3 Outlook

  • 11.4 Acknowledgement

• 12. Target-directed Drug Discovery

  • Tracey D. Bradshaw

  • 12.1 Introduction

  • 12.2 Tyrosine Kinases – Role and Significance in Cancer

  • 12.3 Targeted Therapy for the Treatment of Non-small Cell Lung Cancer (NSCLC)

  • 12.4 Targeted Therapy for the Treatment of Chronic Myeloid Leukaemia

  • 12.5 Targeted Therapy for the Treatment of Breast Cancer

  • 12.6 Angiogenesis

  • 12.7 Targeting Cell Cycling

  • 12.8 Targeting Apoptosis

  • 12.9 Targeting mTOR

  • 12.10 The Future of Molecularly Targeted Therapy

• 13. Tumour Hypoxia: Malignant Mediator

  • Jill L. O’Donnell, Aoife M. Shannon, and David Bouchier-Hayes

  • 13.1 Introduction

  • 13.2 Hypoxia Inducible Factor-1 and Hypoxia

• 14. Drug Resistance in Cancer Chemotherapy

  • Maria Belimezi

  • 14.1 Introduction

  • 14.2 What are the Factors Limiting the Efficacy of Cancer Chemotherapy Treatment?

  • 14.3 A Classification of the Important Chemotherapy Resistance Mechanisms

  • 14.4 Illustrative Mechanisms of Pharmacokinetic Resistance

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Tags: Sotiris Missailidis, Anticancer, Therapeutics