Antidepressants 1st Edition by Brian Leonard – Ebook PDF Instant Download/Delivery: 9783034895262, 3034895267
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Product details:
ISBN 10: 3034895267
ISBN 13: 9783034895262
Author: Brian E. Leonard
Important clinical issues as the outcome of long term treatment with antidepressants, the time of onset of the antidepressant response and the limitations of the antidepressants currently available are covered in this monograph. Leading researchers in the area of clinical and experimental psychopharmacology critically assess the progress in their specialist fields. The mechanisms of action of antidepressants are considered, followed by clinical research into the role of the hypothalamic-pituitary-adrenal axis and the immune system in the biology of depression and in response to treatment. The final chapter deals with the important chemical entities now undergoing development as antidepressants. The purpose of this monograph is not only to inform but also to stimulate research into the biology of depression and the mechanisms behind the action of effective antidepressants. This monograph is of interest to psychiatrists, psychologists, pharmacologists, neuroscientists and endocrinologists.
Table of contents:
Chapter 1: Long-term Course, Comorbidity and Long-term Outcome in Depressive Disorders
Chapter 2: Do Antidepressants Really Take Several Weeks to Show Effect?
Chapter 3: Commentary on the Limitation of Antidepressants in Current Use
Chapter 4: Mechanisms Underlying the Speed of Onset of Antidepressant Response
Chapter 5: Calcium Signaling Cascades, Antidepressants and Major Depressive Disorders
Chapter 6: The Hypothalamic-Pituitary-Adrenal Axis and Antidepressant Action
Chapter 7: Neuroendocrine Markers of Depression and Antidepressant Drug Action
Chapter 8: Brain Cytokines and the Psychopathology of Depression
Chapter 9: Chemistry and Pharmacology of Novel Antidepressants
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