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Applications of Microdialysis in Pharmaceutical Science 1st Edition by Tung Hu Tsai 9780470409282 0470409282

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Applications of Microdialysis in Pharmaceutical Science 1st Edition Tung-Hu Tsai Digital Instant Download

Author(s): Tung-Hu Tsai
ISBN(s): 9780470409282, 0470409282
Edition: 1
File Details: PDF, 13.28 MB
Year: 2011
Language: english
SKU: EB-2544784 Category: Tag:

Applications of Microdialysis in Pharmaceutical Science 1st Edition by Tung Hu Tsai – Ebook PDF Instant Download/Delivery: 9780470409282, 0470409282

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ISBN 10: 0470409282

ISBN 13: 9780470409282

Author: Tung-Hu Tsai

Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces. This book explores the full range of clinical applications for microdialysis, focusing on its use in different organ and tissue systems for pharmacokinetic and pharmacodynamic studies. Readers gain a full understanding of the underlying science of microdialysis, current techniques and practices, as well as its many applications in pharmaceutical research.

Applications of Microdialysis in Pharmaceutical Science starts with an introduction to basic principles and then covers analytical considerations, pharmacodynamic and pharmacokinetic studies, clinical aspects, and special applications. Topics include:

  • Role of microdialysis in drug development, including crucial sampling considerations and applications for nervous system diseases

  • Continuous measurement of glucose concentrations in diabetics

  • Applications for clinical evaluation and basic research on organ systems, including monitoring exogenous and endogenous compounds in the lungs

  • Pharmacokinetic and pharmacodynamic evaluation of anticancer drugs

  • Comparison of microdialysis with imaging approaches to evaluate in vivo drug distribution

  • Special applications of microdialysis in studies of cell culture assays, drug-drug interactions, and environmental monitoring

Throughout the book, readers will find simple models that clarify complex concepts and easy-to-follow examples that guide them through key applications in pharmaceutical research. In short, this book enables pharmaceutical researchers to take full advantage of microdialysis techniques for the preclinical and clinical evaluation of drugs and much more.

Table of contents:

  1. Introduction to Applications of Microdialysis in Pharmaceutical Science

  2. Microdialysis in Drug Discovery

  3. Analytical Considerations for Microdialysis Sampling

  4. Monitoring Dopamine in the Mesocorticolimbic and Nigrostriatal Systems by Microdialysis: Relevance for Mood Disorders and Parkinson’s Disease

  5. Monitoring Neurotransmitter Amino Acids by Microdialysis: Pharmacodynamic Applications

  6. Microdialysis as a Tool to Unravel Neurobiological Mechanisms of Seizures and Antiepileptic Drug Action

  7. Microdialysis in Lung Tissue: Monitoring of Exogenous and Endogenous Compounds

  8. Microdialysis in the Hepatobiliary System: Monitoring Drug Metabolism, Hepatobiliary Excretion, and Enterohepatic Circulation

  9. Microdialysis Used to Measure the Metabolism of Glucose, Lactate, and Glycerol

  10. Clinical Microdialysis in Skin and Soft Tissues

  11. Microdialysis on Adipose Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans

  12. Microdialysis as a Monitoring System for Human Diabetes

  13. Microdialysis Use in Tumors: Drug Disposition and Tumor Response

  14. Microdialysis Versus Imaging Techniques for In Vivo Drug Distribution Measurements

  15. In Vitro Applications of Microdialysis

  16. Microdialysis in Drug–Drug Interaction

  17. Microdialysis in Environmental Monitoring

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Tags: Tung Hu Tsai, Applications, Microdialysis, Pharmaceutical