Autism Current Theories and Evidence 1st Edition by Andrew Zimmerman 354064220X 9783540642206

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Product details:

ISBN 10: 354064220X 

ISBN 13: 9783540642206

Author: Andrew W. Zimmerman

Creative thinking and collaborative scientific research have advanced our understanding of autism, and we are now beginning to synthesize the data into evidence and theories. Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine. This book has 20 chapters divided into 6 sections: Molecular and Clinical Genetics; Neurotransmitters and Cell Signaling; Endocrinology, Growth and Metabolism; Immunology, Maternal-Fetal Effects and Neuroinflammation; Neuroanatomy, Imaging and Neural networks; and Environmental Mechanisms and Models. The subjects cover a wide range of current scientific work in the field of autism, with strong and growing evidence to support them, and demonstrate both the breadth and depth of current autism research. The reader is encouraged to consider how theories and the scientific method, in the hands of these and other dedicated researchers, are leading to greater knowledge and continued progress in autism research.

Table of contents:

1. Molecular and Clinical Genetics

1. Engrailed2 and Cerebellar Development in the Pathogenesis of Autism Spectrum Disorders

2. Teratogenic Alleles in Autism and Other Neurodevelopmental Disorders

3. Cholesterol Deficit in Autism: Insights from Smith–Lemli–Opitz Syndrome

4. Autism in Genetic Intellectual Disability

2. Neurotransmitters and Cell Signaling

5. Serotonin Dysfunction in Autism

6. Excitotoxicity in Autism

7. Prenatal β2-Adrenergic Receptor Signaling and Autism:

3. Endocrinology, Growth, and Metabolism

8. A Role for Fetal Testosterone in Human Sex Differences

9. Interaction between Genetic Vulnerability and Neurosteroids in Purkinje cells as a Possible Neurobiological Mechanism in Autism Spectrum Disorders

10. Insulin-Like Growth Factors

11. Oxidative Stress and the Metabolic Pathology of Autism

4. Immunology, Maternal-Fetal Interaction, and Neuroinflammation

12. The Immune System in Autism

13. Maternal Immune Activation, Cytokines and Autism

14. Maternal Antibodies and the Placental–Fetal IgG Transfer Theory

15. Can Neuroinflammation Influence the Development of Autism Spectrum Disorders?

5. Neuroanatomy and Neural networks

16. The Significance of Minicolumnar Size Variability in Autism

17. Imaging Evidence for Pathological Brain Development in Autism Spectrum Disorders

18. Information Processing, Neural Connectivity, and Neuronal Organization

6. Environmental Mechanisms and Models

19. Evidence for Environmental Susceptibility in Autism

20. An Expanding Spectrum of Autism Models

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Tags: Andrew Zimmerman, Autism, Theories, Evidence