Bioanalytical Separations Volume 4 Handbook of Analytical Separations 1st Edition by Ian Wilson 0444506586 9780444506580

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ISBN 10: 0444506586

ISBN 13: 9780444506580

Author: Ian D. Wilson

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids.

– Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids
– Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use
– Future trends are identified, in terms of the potential impact of new technologies

Table of contents:

Chapter 1: New developments in integrated sample preparation for bioanalysis
1.1 Introduction
1.2 Chromatography-based Extraction Techniques
1.3 Diffusion-based Extraction Techniques
1.4 Concluding Remarks
1.5 Acknowledgments
1.6 List of Abbreviations

Chapter 2: Solid-phase extraction on molecularly imprinted polymers
2.1 Introduction
2.2 Imprint Preparation
2.3 Mispe Method Development Strategies
2.4 Solid-phase Extraction Applications
2.5 Conclusions

Chapter 3: Techniques for sample preparation using solid-phase extraction
3.1 Introduction
3.2 Description of the Sorbents
3.3 Off-Line Methods
3.4 Cation-Exchange Solid Phase Extraction
3.5 Anion-Exchange Solid Phase Extraction
3.6 On-Line Methods
3.7 Conclusions

Chapter 4: Turbulent flow chromatography in bioanalysis
4.1 Introduction
4.2 Background
4.3 Applications of Turbulent Flow Chromatography
4.4 Conclusions

Chapter 5: Chiral bioanalysis
5.1 Introduction
5.2 Chiral Stationary Phases
5.3 Applications of Chiral Hplc in Bioanalysis
5.4 Conclusions

Chapter 6: Method development in reversed-phase chromatography
6.1 Introduction
6.3 Method Development Strategy
6.4 Conclusion

Chapter 7: Immobilized enzyme reactors in liquid chromatography: On-line bioreactors for use in synthesis and drug discovery
7.1 Introduction
7.2 Immobilized Enzymes
7.3 On-Line Immobilized Enzyme Reactors (IMERS)
7.4 Immobilized Enzymes and Imers in Drug Discovery

Chapter 8: Use of liquid chromatography–mass spectrometry in acute human toxicology
8.1 Introduction
8.2 Methodical Considerations
8.3 Applications of Lc–Ms in Clinical Toxicological Analysis
8.4 Conclusions and Perspectives
8.5 Abbreviations Used in The Text

Chapter 9: HPLC–MS(MS) for bioanalysis in drug discovery and development
9.1 Introduction
9.2 The Use of Generic Methods
9.3 Sample Pooling and Cocktail Dosing
9.4 Short Column HPLC
9.5 Sample Introduction Onto HPLC
9.6 The Use of Gradient Elution With High Flow Rates
9.7 Conclusions
9.8 Acknowledgments

Chapter 10: Biomedical applications of directly-coupled chromatography–nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS)
10.1 Introduction
10.2 Technical Developments in HPLC–NMR and HPLC–NMR–MS
10.3 Operational Methods in HPLC–NMR and HPLC–NMR–MS
10.4 Applications in Combinatorial Chemistry
10.5 Application to Drug Impurities
10.6 Chiral HPLC–NMR and HPLC–CD for Pharmaceutical Mixtures
10.7 Application to Natural Products
10.8 Application to Drug Metabolism
10.9 Future Developments
10.10 Conclusions

Chapter 11: Ultra-sensitive detection of radiolabelled drugs and their metabolites using accelerator mass spectrometry
11.1 Introduction
11.2 Instrumentation
11.3 Sample Preparation
11.4 Data Analysis
11.5 Applications
11.6 Limits of Detection and Quantification
11.7 Conclusions and The Future

Chapter 12: Biomedical applications of inductively coupled plasma mass spectrometry (ICP–MS) as an element specific detector for chromatographic separations
12.1 An Introduction to ICP–MS
12.2 ICP–MS As an Element Specific Detector for Chromatographic Separations
12.3 Applications of ICP–MS In the Biomedical Field
12.4 Summary
12.6 Appendix

Chapter 13: Chromatography in a regulated environment
13.1 Introduction
13.2 Regulatory Issues
13.4 Study Documentation
13.5 Statistical Considerations
13.6 The Future
13.7 Conclusion

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Tags: Ian Wilson, Bioanalytical, Separations, Analytical