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Biomarkers for Immunotherapy of Cancer Methods and Protocols 1st Edition by Magdalena Thurin, Alessandra Cesano, Francesco Marincola 1493997726 9781493997725

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Biomarkers for Immunotherapy of Cancer 1st Edition Magdalena Thurin Digital Instant Download

Author(s): Magdalena Thurin, Alessandra Cesano, Francesco M. Marincola
ISBN(s): 9781493997725, 1493997726
Edition: 1st
File Details: PDF, 24.74 MB
Year: 2019
Language: english
SKU: EB-47712158 Category: Tags: , ,

Biomarkers for Immunotherapy of Cancer Methods and Protocols 1st Edition by Magdalena Thurin, Alessandra Cesano, Francesco Marincola – Ebook PDF Instant Download/Delivery: 1493997726, 9781493997725

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Product details:

ISBN 10: 1493997726 

ISBN 13: 9781493997725

Author: Magdalena Thurin, Alessandra Cesano, Francesco M. Marincola

This book provides the immune oncology (IO) community with a deeper understanding of the scope of the biomarker methods to potentially improve the outcome from immunotherapy. The editors secured the input from experts in the field dedicated to translating scientific research from bench to bedside was submitted. The book provides not only details about the technical, standardization and interpretation aspects of the methods but also introduces the reader to the background information and scientific justification for selected biomarkers and assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Table of contents:

  1. Status of Immune Oncology: Challenges and Opportunities

  2. Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors

  3. Measuring Tumor Mutational Burden Using Whole-Exome Sequencing

  4. Germline Genetics in Immuno-oncology: From Genome-Wide to Targeted Biomarker Strategies

  5. Detection of Microsatellite Instability Biomarkers via Next-Generation Sequencing

  6. Genetic Instability Markers in Cancer

  7. Validation of Circulating Tumor DNA Assays for Detection of Metastatic Melanoma

  8. Techniques Associated with Exosome Isolation for Biomarker Development: Liquid Biopsies for Ovarian Cancer Detection

  9. Identifying MicroRNA Pathway Variants as Biomarkers of Patient Selection for Immune Therapy

  10. Histone Modifications as Biomarkers for Immunotherapy

  11. Functional Genome Profiling to Understand Cancer Immune Responsiveness

  12. Using RNA Sequencing to Characterize the Tumor Microenvironment

  13. Development of Gene Expression-Based Biomarkers on the nCounter® Platform for Immuno-Oncology Applications

  14. The CRISPR System and Cancer Immunotherapy Biomarkers

  15. HLA Class I Antigen Processing Machinery Defects in Cancer Cells

  16. High-Parameter Immune Profiling with CyTOF

  17. The Adaptome as Biomarker for Assessing Cancer Immunity and Immunotherapy

  18. Single-Molecule Arrays for Ultrasensitive Detection of Blood-Based Biomarkers for Immunotherapy

  19. Single-Cell Multiplexed Proteomics on the IsoLight

  20. Methods to Detect Immunogenic Cell Death In Vivo

  21. Overview of Tissue Imaging Methods

  22. Multiplex Immunofluorescence Assays

  23. Multiplexed Immunohistochemical Consecutive Staining on Single Slide (MICSSS)

  24. Cyclic Multiplexed-Immunofluorescence (cmIF)

  25. High-Plex Spatially Resolved RNA and Protein Detection Using Digital Spatial Profiling

  26. The InSituPlex® Staining Method for Multiplexed Immunofluorescence Cell Phenotyping

  27. Microbiome as an Immunological Modifier

  28. Systems Biology for Multiplatform Data Integration: An Overview

  29. Bioinformatics Tools and Resources for Cancer Immunotherapy Study

  30. Multiplatform Integrative Analysis of Immunogenomic Data for Biomarker Discovery

  31. Translating Immuno-oncology Biomarkers to Diagnostic Tests: A Regulatory Perspective

  32. Correction to: Methods to Detect Immunogenic Cell Death In Vivo

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Tags: Magdalena Thurin, Alessandra Cesano, Francesco Marincola