Biomedical Applications of Lanthanum 1st Edition by Godfried Roomans, Harriet Nilsson, Anca Dragomir 1617615110 9781617615115

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Product details:

ISBN 10: 1617615110 

ISBN 13: 9781617615115

Author: Godfried M. Roomans; Harriet Nilsson; Anca Dragomir

Lanthanum has been used as a tracer to study tight junctions in epithelia by transmission electron microscopy. The key function of the tight junction complex (TJC) is to limit the paracellular permeability by forming a selectively permeable barrier between the apical and basolateral compartment of the extracellular space. Impaired regulation of the TJC causes a variety of diseases, such as autoimmune diseases, cancer development, infections, allergies and asthma. The advantage of lanthanum as an opaque probe is its small ionic radius (0.11 nm), compared to alternative methods, such as radioactive isotope techniques using extracellular tracers and light microscopy techniques with larger polar molecules. This book presents a variety of biomedical applications of lanthanum.

Table of contents:

Lanthanum as a tracer for the study of tight junctions

Structure and function of tight junctions

Methods to study the permeability of tight junctions in cell cultures

Lanthanum in the study of tight junctions in different tissues

Lanthanum as an inhibitor of ion channels

Uptake of lanthanum salts in the body

Lanthanum carbonate in the treatment of hyperphosphatemia in end stage renal disease.

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Tags: Godfried Roomans, Harriet Nilsson, Anca Dragomir, Biomedical