Part 1: Neuroimmunology and Immune-Mediated Demyelination
Chapter 1: The Spectrum of Neuroimmunologic Diseases
Chapter 2: Heterogeneity in Multiple Sclerosis – Alastair Compston
Chapter 3: Microglia and Brain Macrophages – Jack P. Antel, Rosanne Seguin
Chapter 4: Humoral Immune Response and Antibody-Mediated Brain Injury – Nicole Kerlero de Rosbo, Avraham Ben-Nun
Chapter 5: Antibody-Mediated Remyelination – Allan J. Bieber, Arthur E. Warrington, Virginia Van Keulen, Bogoljub Ciric, Larry R. Pease, Moses Rodriguez
Chapter 6: Apoptosis in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis (EAE) – Daniel Offen, Ronit Mosberg-Galili, Eldad Melamed
Chapter 7: Cell Migration and Adhesion Molecules at the Blood–Brain Barrier in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis – Juan J. Archelos, Bernd C. Kieseier, Hans-Peter Hartung
Chapter 8: Matrix Metalloproteinases and Their Inhibitors in Brain Injury and Repair – Ariel Miller, Sarah Shapiro, Nitza Lahat, Yanina Galboiz
Chapter 9: Monitoring Progression of Multiple Sclerosis: p-Cresol Sulfate is the Dominant Component of Urine – Ligong Cao
Chapter 10: Immunomodulation and Therapy in Multiple Sclerosis – Arnon Karni, Karim Makhlouf, Samia J. Khoury, Howard L. Weiner
Chapter 11: Immunogene Therapy for Autoimmune Demyelination – Roberto Furlan, Pietro L. Poliani, Alessandra Bergami, Francesca Ruffini, Elena Brambilla, Peggy M. Marconi, Giancarlo Comi, Gianvito Martino
Chapter 12: DNA Vaccination for Central Nervous System Autoimmune Diseases – Nathan Karin
Chapter 13: Stem Cell Transplantation for Neurological Diseases: New Hope for Disorders of Myelin? – Tamir Ben-Hur
Part 2: Infections and Lymphoproliferative Disorders
Chapter 14: Viruses in Neurological Disease – Jill R. Breen, Donald H. Gilden
Chapter 15: Chronic Fatigue Syndrome and Systemic Viral Infections: Current Evidence and Recent Advances – Abhijit Chaudhuri, John Gow, Peter O. Behan
Chapter 16: Bacterial Meningitis – Hans-Walter Pfister, Uwe Koedel
Chapter 17: Human Prion Diseases – Amos D. Korczyn
Chapter 18: Neurologic Manifestations of Lymphoproliferative Disorders – Tali Siegal
Part 3: Vascular and Traumatic Events: Pathogenesis and Repair
Chapter 19: Cerebrovascular Disorders: Therapeutic Strategies and Repair – Jorge Moncayo Gaete, Julien Bogousslavsky
Chapter 20: Vasculitis of the Nervous System – Aksel Siva
Chapter 21: Brain Vasculitis and Antiphospholipid Syndrome – Lubica Rauova, Joab Chapman, Yehuda Shoenfeld
Chapter 22: Neuronal Protection in Cerebral Ischemia: From Lessons of the Past to a Brighter Future – Ronen R. Leker
Chapter 23: Immunomodulation – New Therapeutic Opportunities for Stroke – Giora Z. Feuerstein, Xinkang Wang
Chapter 24: Toxicity of Tumor Necrosis Factor Enhanced by Reactive Oxygen Species After Brain Trauma – Esther Shohami
Chapter 25: Protective Autoimmunity: Is Vaccination for Neurodegenerative Disorders Feasible? – Michal Schwartz
Chapter 26: The Molecular Biology of Blood–Brain Barrier Disruption Under Stress: The Potential Involvement of Acetylcholinesterase – Hermona Soreq, Daniela Kaufer, Ilan Shelef, Haim Golan, Oren Tomkins, David Glick, Eli Reichenthal, Alon Friedman
Part 4: Treatment of Epilepsy and Paroxysmal Syndromes
Chapter 27: Clinically Important Interactions Involving New Antiepileptic Drugs – Yitzhak Schiller
Chapter 28: Challenges in Monitoring the New Antiepileptic Drugs – Svein I. Johannessen, Torbjörn Tomson
Chapter 29: Aggravation of Seizures by Antiepileptic Drugs: Pathophysiology and Clinical Implications – Miri Y. Neufeld
Chapter 30: Management of Paroxysmal Symptoms in Multiple Sclerosis – Christian Confavreux, Françoise Bouhour, Sandra Vukusic
Part 5: Degenerative Diseases
Chapter 31: An Update on Therapy for Parkinson’s Disease – Sharon Hassin-Baer, Nir Giladi
Chapter 32: Restoring Structure and Function of the Nigrostriatal System in Parkinson’s Disease – Olle Lindvall, Peter Hagell
Chapter 33: Therapeutics of Hyperkinetic Movement Disorders – Jose Martin Rabey
Chapter 34: Molecular Events in Dopaminergic Neurodegeneration and Neuroprotection in MPTP Model of Parkinson’s Disease Employing cDNA Microarray – Silvia Mandel, Edna Grünblatt, Yona Levites, Gila Maor, Moussa B.H. Youdim
Chapter 35: Alzheimer’s Disease – Abdalla Bowirrat, Robert P. Friedland, Amos D. Korczyn
Part 6: Nerve and Muscle
Chapter 36: Vasculitic Neuropathies – Gérard Said
Chapter 37: Acquired Demyelinating Neuropathies: Molecular Mechanisms and Novel Therapeutical Approaches – Nicole Schaeren-Wiemers, Andreas J. Steck, David Leppert, Peter Fuhr, Alexander J. Radziwill, Susanne Ranaud
Chapter 38: Radiation Damage to Peripheral Nerves – Alexander Lossos, Ofer Merimsky
Chapter 39: Neuropathy Due to Malignant Hematological Diseases – Austin J. Sumner
Chapter 40: Hereditary Inclusion Body Myopathies: Clinical and Genetic Features – Zohar Argov
Chapter 41: Exercise Testing in Muscle Disease – John Vissing
Part 7: Specific Neurological Symptoms
Chapter 42: Disorders of Emotional Behavior – J.P. Newman
Chapter 43: Cognitive and Affective Disturbances in Multiple Sclerosis – Jürg Kesselring, Ulrike Klement
Chapter 44: From Spinal Shock to Spasticity
Chapter 45: Pathophysiology and Treatment of Fatigue in Multiple Sclerosis – Giancarlo Comi, Letizia Leocani, Bruno Colombo, Paolo Rossi
Chapter 46: Management of Vertigo and Vestibular Disorders – Thomas Brandt
Chapter 47: Eye Movements: Supranuclear Mechanisms and Their Disorders – Lea Averbuch-Heller
Part 8: Imaging and Clinical Neurophysiology
Chapter 48: The Role of Radionuclide Brain Scan and Multimodality – Isabelle Berry, Pierre Duthil, Frédéric Courbon, Slimane Zerdoud, Monique Bessou, Michel Clanet, Claude Manelfe
Chapter 49: Imaging Brain Inflammation – Marco Rovaris, Massimo Filippi
Chapter 50: Advances in Neurosonology – Michael Hennerici, Stephen Meairs
Chapter 51: Neurophysiology of Inflammatory Demyelinating Disease – Kenneth J. Smith