Brain extracellular matrix in health and disease 1st Edition by Alexander Dityatev, Bernhard Wehrle Haller, Asla Pitkänen 9780444634948 0444634940

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Product details:

ISBN 10: 0444634940

ISBN 13: 9780444634948

Author: Alexander Dityatev, Bernhard Wehrle-Haller, Asla Pitkänen

In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells.

• Authors are the leading experts in the field of brain extracellular matrix in health and disease
• Book covers the most important aspects of brain extracellular matrix in health and disease
• Interesting for both scientists and clinicians

Table of contents:

PART 1: FUNCTIONS OF NEURAL ECM
Chapter 1: Regulation of the neural stem cell compartment by extracellular matrix constituents
Chapter 2: Neural ECM and synaptogenesis
Chapter 3: Neural ECM molecules in synaptic plasticity, learning, and memory
Chapter 4: Neural ECM molecules in axonal and synaptic homeostatic plasticity
Chapter 5: ECM receptors in neuronal structure, synaptic plasticity, and behavior

PART 2: NEURAL ECM IN BRAIN DISEASES
Chapter 6: Neural ECM proteases in learning and synaptic plasticity
Chapter 7: Neural ECM in laminar organization and connectivity development in healthy and diseased human brain
Chapter 8: Neural ECM in regeneration and rehabilitation
Chapter 9: On the structure and functions of gelatinase B/Matrix metalloproteinase-9 in neuroinflammation
Chapter 10: ECM in brain aging and dementia
Chapter 11: Neural ECM and epilepsy
Chapter 12: Neural ECM in addiction, schizophrenia, and mood disorder

PART 3: NEURAL ECM-TARGETING TOOLS AND THERAPEUTICS
Chapter 13: Current microscopic methods for the neural ECM analysis
Chapter 14: Endogenous and synthetic MMP inhibitors in CNS physiopathology
Chapter 15: Targeting of ECM molecules and their metabolizing enzymes and receptors for the treatment of CNS diseases

PART 4: NEURAL ECM SCAFFOLDS
Chapter 16: Neural ECM mimetics
Chapter 17: Integration of microstructured scaffolds, neurons, and multielectrode arrays
Chapter 18: Intracellular signaling and perception of neuronal scaffold through integrins and their adapter proteins

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Tags: Alexander Dityatev, Bernhard Wehrle Haller, Asla Pitkänen, Brain