Brook s Clinical Pediatric Endocrinology 6th Edition by Charles G D Brook, Peter Clayton, Rosalind Brown ISBN 1444316729 9781444316728

Brook s Clinical Pediatric Endocrinology 6th Edition by Charles G D Brook, Peter Clayton, Rosalind Brown – Ebook PDF Instant Download/Delivery: 1444316729, 9781444316728
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ISBN 10: 1444316729 
ISBN 13: 9781444316728
Author: Charles G D Brook, Peter Clayton, Rosalind Brown

An exceptional editorial team and internationally renowned contributors come together to bring you Brook&;s Clinical Pediatric Endocrinology. This new book is full of practical advice and is essential reading for everyone involved in the care of children and adolescents with endocrine disease and disorders.

This outstanding reference book has been fully updated to feature new concepts, new investigations and new molecular mechanisms and is full of practical, clinical advice. The perfect text for pediatric endocrinologists, endocrinologists and pediatricians.

Brook s Clinical Pediatric Endocrinology 6th Table of contents:

Part I: General Principles and Evaluation

• Chapter 1: Genetics and Genomics in Pediatric Endocrinology
  • Basic Concepts in Human Genetics and Genomics
  • Classes of RNA Molecules and their Functions
  • Gene Mutations and Inheritance Patterns
  • Human Populations and Genetic Variation
  • Epigenetics and its Role
  • Advances in Genomic Analysis and Variant Causality
  • The Age of Precision Medicine
• Chapter 2: Principles of Hormone Action
  • Endocrine Gland Development and Physiology
  • Hormone Synthesis, Secretion, and Transport
  • Receptor Types and Signaling Pathways (Intracellular, Membrane)
  • Regulation of Hormone Action: Feedback Loops, Desensitization
• Chapter 3: Measuring Hormones, Molecular Tests, and Their Clinical Application
  • Principles of Hormone Assays: Immunoassays, Mass Spectrometry
  • Assay Validity, Sensitivity, and Specificity
  • Technical Pitfalls in Hormone Measurement
  • Dynamic Endocrine Testing: Stimulation and Suppression Tests
  • Molecular Diagnostics and Genetic Testing in Endocrine Disorders
• Chapter 4: Fetal Endocrinology and the Transition to Neonatal Life
  • Development of Fetal Endocrine Systems
  • Transplacental Passage of Hormones
  • Fetal Adaptations for Extrauterine Life
  • Endocrine Disorders in the Neonate

Part II: Disorders of Growth and Development

• Chapter 5: Normal Growth and Growth Monitoring
  • Physiology of Growth: Genetic and Environmental Influences
  • Growth Charts and Auxology
  • Pillars of Normal Growth: GH, IGF-I, Thyroid Hormone, Nutrition
• Chapter 6: Evaluation of Growth Disorders
  • Approach to the Child with Short Stature
  • Differential Diagnosis of Short Stature (Proportionate vs. Disproportionate)
  • Laboratory and Imaging Investigations for Short Stature
  • Approach to the Child with Tall Stature
• Chapter 7: Congenital Disorders of the Hypothalamo-Pituitary-Somatotrope Axis
  • Pituitary Development and Congenital Hypopituitarism
  • GH Deficiency: Etiology, Diagnosis, and Clinical Manifestations
  • Genetic Causes of GH Deficiency and Pituitary Dysplasia
  • Management of GH Deficiency
• Chapter 8: Acquired Disorders of the Hypothalamo-Pituitary Axis
  • Causes of Acquired Hypopituitarism (Tumors, Trauma, Infiltrative Diseases)
  • Growth Hormone Excess (Gigantism)
  • Disorders of Posterior Pituitary: Diabetes Insipidus and SIADH
  • Craniopharyngioma and Other Pituitary Tumors
• Chapter 9: Management of Disordered Growth
  • Growth Hormone Therapy: Indications, Efficacy, Side Effects
  • Management of Primary IGF-I Deficiency
  • Treatment of Short Stature in Specific Syndromes (e.g., Turner Syndrome)
  • Management of Tall Stature

Part III: Disorders of Puberty and Sex Development

• Chapter 10: Normal Puberty
  • Physiology of Pubertal Onset and Progression (Gonadarche, Adrenarche)
  • Hormonal Changes During Puberty in Boys and Girls
  • Pubertal Growth Spurt and Bone Maturation
• Chapter 11: Evaluation of Disordered Puberty
  • Precocious Puberty: Central vs. Peripheral
  • Delayed Puberty: Hypogonadotropic vs. Hypergonadotropic Hypogonadism
  • Gynecomastia in Childhood and Adolescence
• Chapter 12: Management of Disordered Puberty
  • Treatment of Precocious Puberty
  • Induction of Puberty in Delayed Puberty
  • Management of Pubertal Disorders in Specific Conditions
• Chapter 13: Disorders of Sex Development (DSD)
  • Normal Sex Development: Chromosomal, Gonadal, Phenotypic
  • Classification and Etiology of DSD
  • Evaluation and Diagnosis of DSD
  • Management of DSD: Medical, Surgical, Psychological Aspects
  • Ethical Considerations in DSD Management
• Chapter 14: Polycystic Ovarian Syndrome (PCOS) and Androgen Excess in Adolescents
  • Pathogenesis and Clinical Features of PCOS
  • Diagnosis and Management of PCOS
  • Differential Diagnosis of Hirsutism and Virilization

Part IV: Disorders of Specific Endocrine Glands

• Chapter 15: The Thyroid Gland and Its Disorders
  • Thyroid Development and Physiology
  • Congenital Hypothyroidism: Screening, Diagnosis, and Management
  • Acquired Hypothyroidism: Hashimoto’s Thyroiditis
  • Hyperthyroidism: Graves’ Disease and Other Causes
  • Thyroid Nodules and Thyroid Carcinoma in Children
• Chapter 16: The Adrenal Cortex and Its Disorders
  • Adrenal Development, Steroidogenesis, and Regulation
  • Congenital Adrenal Hyperplasia (CAH): Diagnosis and Management
  • Adrenal Insufficiency (Addison’s Disease)
  • Cushing’s Syndrome: Etiology, Diagnosis, and Treatment
  • Primary Aldosteronism and Other Mineralocorticoid Disorders
• Chapter 17: The Parathyroid Glands and Disorders of Calcium and Bone Metabolism
  • Physiology of Calcium, Phosphate, and Vitamin D Homeostasis
  • Hypocalcemia: Causes, Diagnosis, and Management
  • Hypercalcemia: Causes, Diagnosis, and Management
  • Rickets and Osteomalacia
  • Osteoporosis and Other Bone Disorders in Childhood
• Chapter 18: Disorders of Water Balance
  • Physiology of ADH and Water Homeostasis
  • Diabetes Insipidus (Central and Nephrogenic)
  • Syndrome of Inappropriate ADH Secretion (SIADH)
  • Disorders of Sodium Homeostasis (Hypernatremia, Hyponatremia)

Part V: Metabolic and Other Endocrine Disorders

• Chapter 19: Diabetes Mellitus in Childhood and Adolescence
  • Type 1 Diabetes: Pathogenesis, Diagnosis, Management
  • Type 2 Diabetes: Epidemiology, Diagnosis, and Management
  • Monogenic Diabetes (MODY, Neonatal Diabetes)
  • Diabetic Ketoacidosis and Hypoglycemia
  • Complications of Diabetes in Children
• Chapter 20: Hypoglycemia: Assessment and Management
  • Physiology of Glucose Homeostasis
  • Causes of Hypoglycemia in Neonates, Infants, and Children
  • Hyperinsulinism: Diagnosis and Management
  • Hypoglycemia in Specific Conditions
• Chapter 21: Childhood Obesity and Metabolic Syndrome
  • Epidemiology and Etiology of Childhood Obesity
  • Monogenic and Syndromic Obesity
  • Metabolic Complications of Obesity
  • Assessment and Management Strategies for Childhood Obesity
• Chapter 22: Endocrine Neoplasia in Childhood
  • General Principles of Endocrine Tumors
  • Multiple Endocrine Neoplasia (MEN) Syndromes
  • Adrenal Tumors, Pheochromocytoma, and Paraganglioma
  • Thyroid Carcinoma
  • Pituitary Tumors
• Chapter 23: Polyglandular Syndromes and Autoimmune Endocrinopathies
  • Autoimmune Polyglandular Syndromes (APS Type 1, 2, 3)
  • Specific Autoimmune Endocrine Disorders

Part VI: Special Considerations

• Chapter 24: Ethical Issues in Clinical Pediatric Endocrinology
  • Consent and Assent in Pediatric Care
  • Ethical Dilemmas in DSD Management, Puberty Blockade, and Growth Hormone Treatment
  • Genetic Testing and Disclosure
• Chapter 25: Late Effects of Cancer Treatment on the Endocrine System
  • Impact of Chemotherapy and Radiation on Endocrine Glands
  • Long-Term Surveillance and Management
• Chapter 26: Transition from Pediatric to Adult Endocrine Care
  • Challenges and Strategies for Successful Transition
  • Models of Care and Patient Empowerment

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Tags: Charles G D Brook, Peter Clayton, Rosalind Brown, Clinical, Endocrinology