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Cancer Drug Resistance 1st Edition by Beverly Teicher 9781597450355 1597450359

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Cancer Drug Resistance 1st Edition Mark W. Dewhirst Dvm Digital Instant Download

Author(s): Mark W. Dewhirst DVM, PhD, Yiting Cao MD, PhD, Benjamin Moeller PhD, Chuan-Yuan Li PhD (auth.), Beverly A. Teicher PhD (eds.)
ISBN(s): 9781597450355, 1597450359
Edition: 1
File Details: PDF, 5.38 MB
Year: 2006
Language: english
SKU: EB-4395810 Category: Tags: , , , , ,

Cancer Drug Resistance 1st Edition by Beverly Teicher – Ebook PDF Instant Download/Delivery: 9781597450355, 1597450359

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Product details:

ISBN 10: 1597450359

ISBN 13: 9781597450355 

Author: Beverly A. Teicher

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Table of contents:

  1. Physiological Resistance

  2. The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors

  3. Influence of Tumor pH on Therapeutic Response

  4. Tumor Oxygenation and Treatment Response

  5. Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance

  6. PET Imaging of Response and Resistance to Cancer Therapy

  7. Biological Resistance

  8. Cancer Stem Cells Implications for Development of More Effective Therapies

  9. Therapeutic Resistance in Leukemia

  10. Tumor Site Implantation and Animal Model Selection in Oncology

  11. In Vivo Resistance

  12. Characteristics of the Metastatic Phenotype

  13. The Microenvironment and Drug Resistance

  14. Biochemical Resistance

  15. Glutathione and Glutathione S-Transferases in Drug Resistance

  16. Metallothioneins in Drug Resistance

  17. Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors

  18. New and Revised Concepts in Multidrug Resistance

  19. Cisplatin Resistance

  20. Regulation of the Cellular Pharmacology and Cytotoxicity of Cisplatin by Copper Transporters

  21. Resistance To Taxanes

  22. CpG Island Methylation and Drug Resistance

  23. De Novo and Acquired Resistance to Antitumor Alkylating Agents

  24. Resistance to Antiangiogenic Agents

  25. The Role of Hormones, Growth Factors, and Oncogenes

  26. Resistance to Antiestrogens

  27. Mechanisms of Glucocorticoid Actions and Resistance in Multiple Myeloma

  28. Herceptin Resistance

  29. Role of TGF-β in Tumor Progression and Metastasis

  30. p53-Based Immunotherapy of Cancer

  31. Response and Resistance to Ionizing Radiation

  32. Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance

  33. Clinical Aspects of Resistance

  34. Cancer Chemotherapy

  35. Molecular Profiling in Breast Cancer

  36. Tumor Immune Escape Mechanisms

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Tags: Beverly Teicher, Cancer, Drug, Resistance