Cancer of the Uterus 1st Edition by George Coukos, Stephen Rubin 0824754158 978-0824754150

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Product details:

ISBN 10: 0824754158 

ISBN 13: 978-0824754150

Author: George Coukos, Stephen C. Rubin

The only guide to provide comprehensive coverage of the management of endometrial cancer, as well as cancers in, on, and around the uterus. Studies the impact of diagnostic tools, imaging techniques, and sampling procedures in the evaluation and management of various cancers. Discusses late and advanced stage treatments including radiation and surg

Table of contents:

1. Molecular Genetics of Uterine Malignancies
Introduction
Genetic And Environmental Factors
Inherited Risk
Sporadic Cancers: Acquired Genetic Changes
DNA Mismatch Repair Defects
Tumor Suppressor Gene Defects
Oncogenes
Summary
References

2. Endometrial Cancer in the Hereditary Nonpolyposis Colorectal Cancer Syndrome
Introduction
Clinical And Pathologic Features Of Hnpcc-Related Cancers
Endometrial Cancer
Ovarian Cancer
Colorectal Cancer
Other Malignancies
Genetic Basis Of Hnpcc
Identifying The Hnpcc Syndrome
Clinical Diagnosis
Genetic Testing
Testing Recommendations and Interpretation of Results
Counseling Regarding Screening And Prevention
Screening for Gynecologic Cancers (Table 2)
Screening for Colorectal Cancer (Table 2)
Screening for Other Cancers (Table 2)
Lifestyle
Chemoprevention
Prophylactic Surgery
Gynecologic Cancer
Colorectal Cancer
Conclusion
References

3. Steroid Hormone Receptors in the Normal Endometrium and in Endometrial Cancer
Introduction: Endometrial Cancer And The Link To Steroid Hormones And Steroid Receptors
Hormone Receptors In The Normal Endometrium
Hormonal Effects And Hormone Receptors In Endometrial Cancer
Ligand Binding Assays And Immunohistochemistry To Determine Steroid Receptor Status
Cross-Talk And Expression In Endometrial Glands And Stroma
Genomic Effects Of Srs
Receptor Isoforms
Non-Genomic Effects Of Steroid Hormones Through Membrane And Cytosolic Receptors
References

4. The Effects of Tamoxifen on the Endometrium
Introduction
Endometrial Carcinoma
Histology Of Tamoxifen-Associated Uterine Cancer
The Role Of Screening
References

5. Pathology of Endometrial Hyperplasia and Carcinoma
Classification
Precursors Of Endometrial Carcinoma
Precursors of Type I Carcinomas
Precursors of Type II Carcinomas
Endometrioid Carcinoma
Gross Findings
Microscopic Findings
Differential Diagnosis
Prognostic Factors
Patterns of Spread
Variants of Endometrioid Carcinoma
Villoglandular Adenocarcinoma
Endometrioid Carcinoma with Squamous Differentiation
Gross and Microscopic Findings
Differential Diagnosis
Behavior
Mucinous Carcinoma
Serous Carcinoma
Gross Findings
Microscopic Findings
Differential Diagnosis
Behavior
Clear Cell Carcinoma
Mixed Types Of Carcinoma
Malignant Mesodermal Mixed Tumor (Mmmt)/Carci Nosarcoma
Undifferentiated Carcinoma
Molecular Genetics Of Endometrial Cancer
Endometrioid Carcinoma
Serous Carcinoma
References

6. Pathology of Uterine Sarcomas
Classification Of Uterine Mesenchymal, And Mixed Mesenchymal/Epithelial Neoplasms
Endometrial Stromal Sarcoma (Ess) (1-3)
Clinical Features
Gross Pathology
Microscopic Pathology (Figs. 1 and 2)
Clinicopathologic Correlation
Managerially Relevant Differential Diagnostic Issues
Clinical Disease I (Benign) Conditions with which ESS May Be Confused
Clinical Disease II Conditions with which ESS May Be Confused
Other Clinical Disease II Conditions with which ESS May Be Confused
Clinical Disease IV Conditions with which ESS May Be Confused
Uterine Neoplasms With Sex Cord-Like Elements (26,29,30,41-43)
Leiomyosarcoma (1,3)
Clinical Features
Gross Pathology
Microscopic Appearance (Figs. 4 and 5; Table 3)
Clinicopathologic Correlation
Managerially Relevant Differential Diagnostic Issues
Clinical Disease I (Table 3) with which Leiomyosarcoma May Be Confused
Clinical Disease II (Table 3) with which Leiomyosarcoma May Be Confused
Clinical Disease Ill (Table 3) with which Leiomyosarcoma May Be Confused
Clinical Disease IV (Table 3) with which Leiomyosarcoma May Be Confused
Undifferentiated Uterine Sarcoma (31,32,101)
Miscellaneous Pure Sarcomas
Mixed MÜLlerian Neoplasms
Adenosarcoma (1,119-125)
Clinical Features
Gross Pathology
Microscopic Pathology
Clinicopathologic Correlation
Managerially Relevant Differential Diagnostic Issues
Clinical Disease (Table 3) Considerations
Clinical Disease III (Table 3) Considerations
Clinical Disease IV (Table 3) Considerations
Carcinosarcoma (43,132-136)
Clinical Features
Gross Pathology
Microscopic Pathology (Figs. 7 and 8)
Managerially Relevant Differential Diagnostic Issues
References

7. Clinical Evaluation of Abnormal Uterine Bleeding
Definition
History And Physical Examination
Etiology
Complications of Pregnancy
Infections
Systemic Causes
Benign Lesions
Dysfunctional Bleeding
Malignancy
iatrogenic
Foreign Bodies
Medications
Tamoxifen
Herbal Medicines
Diet and Stress
Diagnosis
Imaging Techniques
Transvaginal Sonography
Sonohysterography (SIS)
Hysterosalpingogram (HSG)
Complications
Endometrial Sampling
Endometrial Cytologic Sampling
Endometrial Biopsy (EMB)
Dilation and Curettage (D&C)
Complications Associated with Endometrial Sampling
Hysteroscopy
Hysteroscopy/EMB
Complications Associated with Hysteroscopy
Dissemination of Tumor Cells
Failed or Missed Diagnosis
References

8. Conservative Treatment of Endometrial Hyperplasia and Early Endometrial Cancer
Introduction
Clinical Characteristics
Progestin Therapy
Anticipation Of Treatment Failure
Treatment Regimens
References

9. The Surgical Management of Early Endometrial Cancer
Introduction
Staging
Prognostic Factors
FIGO Grade
Myometrial Invasion
Lymph Node Metastases
Tumor Histology
Age
Peritoneal Cytology
Adnexal Metastases
Lymph-Vascular Space Invasion (LVSI)
Tumor Size
Hormone Receptor Status
DNA Analysis
SURGICAL APPROACHES
Conclusions
References

10. The Role of Laparoscopy in the Management of Endometrial Cancer
Demand For Laparoscopic Surgery
Historical Perspective: The Development of the Laparoscopic Approach
Surgical Techniques For Laparoscopic Treatment Of Endometrial Cancer
LAVH/BSO
Pelvic Lymphadenectomy
Para-aortic Lymphadenectomy
Current Treatment Algorithms Utilizing Laparoscopy In EC
Surgical Candidate Selection
Obesity
Elderly
TRAINING
Potential Benefits Of Laparoscopic Surgery
Decrease in Wound Disruption and Infection
Decrease in Adhesion Formation
Decreased Hospital Stay
Patient Satisfaction
Cost Containment
Complications Of Laparoscopy
Theoretical Cancer Recurrence and Survival Risk
Gog Experience
References

11. The Role of Primary Surgery in Advanced Endometrial Cancer
Introduction
Theoretical Basis For Cytoreductive Surgery
Stage III Endometrial Cancer
Adnexal Metastasis
Lymph Node Metastasis
Stage IV Endometrial Cancer
Uterine Papillary Serous Carcinoma/Cancer (UPSC)
Conclusion
References

12. Surgical Management of Recurrent Endometrial Cancer
Introduction
Pelvic Exenteration
Surgical Exploration
Resection of Pelvic Organs
Surgical Reconstruction
Palliation
References

13. Radiation Treatment for Early Stage Endometrial Cancer and Uterine Sarcoma
Introduction
Endometrial Cancer
Stages I and II: Postoperative Management
Stages I and II: Irradiation Alone
Stages I and II: Summary
Uterine Sarcoma
Stages I and II: Postoperative management
Mixed Mesodermal Tumors
Leiomyosarcoma
Endometrial Stromal Sarcoma
Stages I and II: Irradiation Alone
Summary
Technique Of External Irradiation
Techniques For HDR Brachytherapy
References

14. Radiation Treatment of Advanced or Recurrent Endometrial Cancer
Role Of Radiation Therapy For Stage III-IV EC
Pathologic Stage III
Positive Peritoneal Cytology Alone
Isolated Adnexal Invasion
Optimally Debulked Stage III
Lymph Node Positive Stage IIIC
Clinical Stage III and IV Disease
Clinical Stage III
Bulky Residual Disease After Surgery
Clinical Stage IV
Radiation Therapy For Pelvic Recurrence
Incidence of Pelvic Recurrence
Treatment of Pelvic Recurrence
Exenteration
Radical Radiation
Pelvic Recurrence
Isolated Vaginal Recurrence
Radiation Therapy For Medically Inoperable Patients
Results of Primary Radiation Treatment
Operable Compared with Medically Inoperable
High-Dose Rate Brachytherapy
Treatment Sequelae
References

15. Systemic Therapies for Endometrial Carcinoma
Endometrioid Endometrial Carcinoma (EEC)
Chemotherapy for Advanced and Recurrent EEC
Adjuvant Chemotherapy for Early Stage EEC
Radiation and Chemotherapy
Hormonal Therapy
Progestins for Advanced or Recurrent Disease
Selective Estrogen Receptor Modulators
Other Hormonal Agents
Adjuvant Hormonal Therapy
Fertility Preservation
Uterine Papillary Serous Carcinoma (UPSC)
Adjuvant Therapy for UPSC
Molecular Therapies
Summary
References

16. Targeted Therapy of Endometrial Cancer
Introduction
Epidermal Growth Factor Receptors
Transforming Growth Factors
PTEN—PI3 Kinase
Angiogenesis
Invasion And Metastasis
Conclusions
References

17. Management of Uterine Sarcomas
Epidemiology And Incidence
Prognostic Factors Carcinosarcomas
Leiomyosarcomas
Endometrial Stromal Sarcomas
Müllerian Adenosarcomas
Surgical Staging Of Uterine Sarcomas
Extended Staging of Uterine Sarcomas
Adjuvant Chemotherapy In Early Uterine Sarcomas
Carcinosarcomas
Leiomyosarcomas
Adjuvant Radiotherapy In Uterine Sarcomas Carcinosarcomas
Leiomyosarcomas
Palliative Chemotherapy In Uterine Sarcomas
Carcinosarcomas
Leiomyosarcomas
Endometrial Stromal Tumors
Müllerian Adenosarcomas
Hormonal Therapy In Uterine Sarcomas
Multimodality Adjuvant Therapy
References

18. Hormone Replacement in the Patient with Uterine Cancer
Conclusion
References

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Tags: George Coukos, Stephen Rubin, Cancer, Uterus