Cardiovascular Implications of Stress and Depression 1st Edition by Paul Chantler, Kevin Larkin ISBN 0128150165 9780128150160

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Product details:

ISBN 10: 0128150165

ISBN 13: 9780128150160

Author:  Paul D. Chantler, Kevin T. Larkin

Cardiovascular Implications of Stress and Depression 1st Edition: 

Cardiovascular Implications of Stress and Depression provides an in-depth examination on how exposure to stress influences risk for cardiovascular disease and how depression is associated with this relationship. This authoritative volume examines causal pathways linking stress, depression and cardiovascular disease. In addition, it provides mechanistic insights into how environmental stress can lead to cardiovascular diseases. Current information about mechanistic factors, clinical and epidemiological aspects, and management issues associated with stress/depression are presented. These insights demonstrate how the mechanisms behind chronic stress and depression lead to cardiovascular diseases. In addition, their role in existing diseases (such as obesity, hypertension, and diabetes) is explored.

• Provides the latest information on how stress leads to depression and how stress/depression interacts to accelerate cardiovascular diseases, including stroke
• Delivers insights on how mechanisms of stress/depression affect vasculature
• Explores how to best research this topic from human and pre-clinical models

 

Cardiovascular Implications of Stress and Depression 1st Edition Table of contents:

Chapter 1: Stress, Depression, and Cardiovascular Disease

• Abstract
• Basic definitions
• Conceptual models linking stress with depression and cardiovascular disease
• Mechanisms linking stress with cardiovascular disease
• Conclusion

Section 1: Evidence Linking Stress with Depression and Cardiovascular Disease

Chapter 2: Epidemiological Evidence Linking Stress and Depression with CVD

• Abstract
• Methodological considerations
• Stress and cardiovascular disease
• Depression and cardiovascular disease
• Conclusion

Chapter 3: Translational Research from Animal Models

• Abstract
• Introduction: The translational value of research with animal models
• Animal models and operational definitions of depression
• Mechanisms, pathways, and physiological correlates
• Concluding remarks

Chapter 4: Intervention Research on Therapies that Aim to Treat Depression and Cardiovascular Disease

• Abstract
• Psychosocial and behavioral interventions
• Cognitive-behavioral therapy
• Collaborative care
• Cardiac rehabilitation and exercise
• Stress management/relaxation training
• Caregiver interventions
• Nutritional interventions
• Pharmacotherapy
• Other pharmacotherapy treatment
• Combined behavioral and psychopharmacology interventions
• Limitations
• Summary of findings and future considerations

Section 2: Mechanisms Linking Stress and Depression with Cardiovascular Disease

Chapter 5: Autonomic and Neuroendocrine Response to Stress

• Abstract
• The autonomic nervous system
• The neuroendocrine system
• Pathological patterns of autonomic nervous and neuroendocrine system functioning
• Exposure to stress and allostatic load
• Allostatic load and risk for cardiovascular disease
• Depression and allostatic load
• Summary and conclusions

Chapter 6: Circulatory System Alterations Under Stress

• Abstract
• Vascular dysfunction
• Potential mechanisms leading to vascular dysfunction and remodeling
• Adverse effect of stress on the heart
• Summary and conclusions

Chapter 7: Human Neuroimaging-Based Connections Between Stress, Cardiovascular Disease, and Depression

• Abstract
• Introduction
• Neuroimaging methods
• Cortical responses to stress and the brain regions affected
• Cortical responses to stress and CVD
• Cortical responses to stress and depression
• Therapies and treatments: Effect on brain
• Summary

Chapter 8: The Role of Inflammation and Oxidative Stress in Depression and Cardiovascular Disease

• Abstract
• Introduction
• Stress as a catalyst for inflammation
• Stress as a catalyst for reactive oxygen species (ROS) accumulation: A role for mitochondrial dysfunction
• Inflammation in the pathophysiology of depression
• ROS in the pathogenesis of depression
• Inflammation in the pathogenesis of CVD
• ROS in the pathogenesis of cardiovascular disease
• Inflammation and ROS responses to stress as a mechanism through which stress leads to depression and cardiovascular disease comorbidity
• Conclusion

Chapter 9: Social Support and Stress, Depression, and Cardiovascular Disease

• Abstract
• The link between stress and social support
• The link between depression and social support
• The link between social support, biological risk, and cardiovascular disease
• Social support as a mediator
• Intervention implications
• Conclusions

Chapter 10: The Influence of Health Behaviors Upon the Association Between Stress, Depression, and Cardiovascular Disease

• Abstract
• Tobacco use
• Alcohol use
• Physical inactivity
• Dietary habits
• Overweight and obesity
• Medication and medical regimen adherence
• Sleep
• Summary

Chapter 11: The Microbiome-Gut-Brain Axis: The Missing Link in Depression

• Abstract
• Introduction
• The bidirectional microbiome-gut-brain axis
• Relationships between stress and the gut microbiome
• Relationships between depression and the gut microbiome
• Early-life stress and depression
• Relationships between cardiovascular disease and the microbiome
• Conclusions and future directions
• Disclosures

Chapter 12: Future Directions and Concluding Remarks

• Abstract
• Causal relations among stress, depression, and cardiovascular disease
• Mechanisms linking stress with depression and cardiovascular disease
• Future research directions

 

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