Cell Cycle Inhibitors in Cancer Therapy Current Strategies 1st Edition by Antonio Giordano, ‎Kenneth Soprano 9781617372575 1617372579

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Product details:

ISBN 10: 1617372579

ISBN 13: 9781617372575

Author: Antonio Giordano; ‎Kenneth J. Soprano

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.

Table of contents:

1. Cdk Inhibitors

2. p27, A Prognostic Indicator Reflecting…?

3. Cell Cycle Control of Transcription at the G1/S Phase Transition

4. Tumor-Suppressor Genes as Diagnostic Tools

5. Regulation of Cell Cycle and Apoptosis

6. CDK Inhibitors as Targets of Chemoprevention Agents

7. Cell Cycle Regulatory Genes as Targets of Retinoids

8. Modulators of Cyclin-Dependent Kinases

9. Cell Cycle Regulators

10. Cell Cycle Regulators as Targets of Anticancer Therapy

11. Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer

12. Synthetic Oligopeptides as Cancer Cell Cycle Modulators

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Tags: Antonio Giordano, Kenneth Soprano, Inhibitors, Therapy