Cellular Transplantation From Laboratory to Clinic 1st Edition by Craig Halberstadt, Dwaine Emerich 0123694159 9780123694157
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ISBN 10: 0123694159
ISBN 13: 9780123694157
Author: Craig Halberstadt, Dwaine F. Emerich
There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy.
Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier.
The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices.
· Provides detailed description of clinical trials in cell transplantation
· Review of current therapeutic approaches
· Coverage of the broad range of diseases addressed by cell therapeutics
· Discussion of stem cell biology and its role in transplantation
Table of contents:
Part A: The Basic Biology of Cell Therapy
Chapter 1. Immunology of Cell and Tissue Xenotransplantation
Chapter 2. Current Immunosuppressive Drugs and Clinical Use
Chapter 3. Stem and Precursor Cells for Transplant Therapy
Chapter 4. Creating Animals for Cell Xenotransplantation
Part B: Cell Therapy for Peripheral Diseases and Reconstructive Applications
Chapter 5. Islet Transplants for Diabetes: The Edmonton Protocol
Chapter 6. Characterization of Islet Preparations
Chapter 7. Encapsulated Human Islet Allografts: Providing Safety with Efficacy
Chapter 8. Strategies for Cell Replacement for Kidney Failure
Chapter 9. Strategies for Extracorporeal Devices for Kidney Failure
Chapter 10. Transplants for Hemophilia
Chapter 11. Cell Therapy for Peripheral Diseases and Reconstructive Applications: Transplants for Lysosomal Storage Diseases (LSD)
Chapter 12. Cellular Transplants for Liver Diseases
Chapter 13. Stem Cell Transplantation for Autoimmune Diseases
Chapter 14. Cardiac Cell Transplantation
Chapter 15. Cylindrical Cartilage Transplantation for Tracheal Replacement
Chapter 16. Muscle Cell Transplants
Part C: Cell Therapy for CNS Diseases
Chapter 17. Immunological Considerations in CNS Transplants
Chapter 18. Neurotrophic Cell Transplants for Degenerative Diseases of the Eye
Chapter 19. Transplants for Glioblastoma
Chapter 20. NT2N Cell Transplantation and GDNF Treatment in Stroke: Linking Neurotrophic Factor Therapy
Chapter 21. NGF-producing Cell Transplants for Alzheimer’s Disease
Chapter 22. Transplants of CNTF-producing Cells for the Treatment of Huntington’s Disease
Chapter 23. Choroid Plexus Epithelial Cell Transplants for Repair of the Brain
Chapter 24. Neural Transplantation in Huntington’s Disease
Chapter 25. Neural Transplantation in Parkinson’s Disease
Chapter 26. Transplants for Chronic Pain
Chapter 27. Cell Grafting for Spinal Cord Injury Repair: Cell Replacement and Bridging Strategies
Chapter 28. Human Embryonic Stem Cells, Dopaminergic Neurons, and Pathways for Developing a Parkinson’s Disease Therapy
Part D: Future Avenues of Cell Therapy
Chapter 29. Concepts in Cell Therapy: From Cord Blood to Sertoli Cells
Chapter 30. Immunologically Privileged Environments
Chapter 31. Converging Cell Therapy with Biomaterials
Chapter 32. Nanotechnology’s Impact on Cell Transplantation
Chapter 33. Design and Implementation of a Cell Processing Facility
Chapter 34. Developing Cell Therapy Products
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Tags: Craig Halberstadt, Dwaine Emerich, Transplantation, Cellular