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Chemogenomics Knowledge Based Approaches to Drug Discovery 1st Edition by Edgar Jacoby 9781860946134 1860946135

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Chemogenomics Knowledge Based Approaches to Drug Discovery 1st Edition Edgar Jacoby (Ed.) Digital Instant Download

Author(s): Edgar Jacoby (Ed.)
ISBN(s): 9781860946134, 1860946135
Edition: 1
File Details: PDF, 4.25 MB
Year: 2006
Language: english
SKU: EB-1939178 Category: Tag:

Chemogenomics Knowledge Based Approaches to Drug Discovery 1st Edition by Edgar Jacoby – Ebook PDF Instant Download/Delivery: 9781860946134, 1860946135

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Product details:

ISBN 10: 1860946135

ISBN 13: 9781860946134

Author: Edgar Jacoby

In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, chemogenomics aims to identify systematically all ligands and modulators for all the gene products expressed and allows the accelerated exploration of their biological function. The subject brings together diverse disciplines including chemistry, genetics, chemo- and bioinformatics, structural biology, and biological screening in phenotypic and target-based assays.This book uniquely integrates reviews of the latest cutting-edge research by leaders in the various disciplines, providing a general, knowledge-centric overview of the different chemical, biological and informatics components. Unlike existing publications, the book focuses on how these disciplines interact efficiently for the rapid discovery of new targets and their effector molecules simultaneously. Examples of chemogenomics approaches pursued in academia as well as in biotech and pharmaceutical companies are also provided.

Table of contents:

  1. Small Molecules for Chemogenomics-based Drug Discovery

  2. Mapping the Chemogenomic Space

  3. Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration

  4. A Reductionist Approach to Chemogenomics in the Design of Drug Molecules and Focused Libraries

  5. In silico Screening of the Protein Structure Repertoire and of Protein Families

  6. New Methods for Similarity-based Virtual Screening

  7. Structural Informatics: Chemogenomics In silico

  8. Construction of a Homogeneous and Informative In vitro Profiling Database for Anticipating Drug Behavior

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Tags: Edgar Jacoby, Chemogenomics, Knowledge, Based