Chemokine Receptors as Drug Targets Methods and Principles in Medicinal Chemistry 1st Edition by Martine J Smit, Sergio A Lira, Rob Leurs ISBN B00BP7S3S8  978-3527321186

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ISBN 10: B00BP7S3S8

ISBN 13: 978-3527321186

Author:  Martine J Smit, Sergio A Lira, Rob Leurs

 Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities.
Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

Chemokine Receptors as Drug Targets Methods and Principles in Medicinal Chemistry 1st Table of contents:

Introduction

• Overview of Chemokines and Chemokine Receptors

• The Role of Chemokine Receptors in Health and Disease

• Drug Development and the Importance of Chemokine Receptors as Drug Targets

• Goals of the Book: Methods and Principles in Medicinal Chemistry

Part I: Understanding Chemokine Receptors

1. Introduction to Chemokine Receptors

   • Basic Structure and Function of Chemokine Receptors

   • Ligands for Chemokine Receptors: Chemokines and Their Specificity

   • The Role of Chemokine Receptors in Immune Responses

2. Mechanisms of Chemokine Receptor Signaling

   • G-Protein Coupled Receptors (GPCRs) and Signal Transduction

   • Downstream Signaling Pathways

   • Internalization and Receptor Desensitization

3. Chemokine Receptors in Human Diseases

   • Inflammation and Immune System Disorders

   • Cancer: Role of Chemokine Receptors in Tumor Progression and Metastasis

   • Viral Infections: Chemokine Receptors as Targets for HIV and Other Pathogens

   • Autoimmune Diseases and Allergies

Part II: Chemokine Receptor Modulation in Drug Discovery

4. Designing Small Molecule Inhibitors of Chemokine Receptors

   • General Principles of Drug Design for GPCRs

   • Structure-Activity Relationships (SAR) of Chemokine Receptor Antagonists

   • Screening Techniques for Identifying Potential Drug Candidates

5. Peptides and Biologics as Modulators of Chemokine Receptors

   • Peptide-Based Drugs Targeting Chemokine Receptors

   • Monoclonal Antibodies and Biologic Agents

   • Advances in Therapeutic Antibodies for Chemokine Receptor Modulation

6. Chemokine Receptor Agonists: Harnessing Their Potential

   • Agonist Design and Their Role in Regenerative Medicine

   • Targeting Chemokine Receptors for Tissue Repair and Inflammation Control

   • Challenges in Developing Safe and Effective Agonists

Part III: Methods in Medicinal Chemistry for Chemokine Receptor Targeting

7. Computational Chemistry in Chemokine Receptor Drug Design

   • Molecular Docking and Virtual Screening

   • Molecular Dynamics Simulations and Receptor-Ligand Interactions

   • QSAR Modeling and Prediction of Drug-Like Properties

8. Synthesis and Chemical Modifications of Chemokine Receptor Ligands

   • Synthetic Approaches to Developing Chemokine Receptor Antagonists

   • Chemical Modification for Enhancing Selectivity and Bioavailability

   • Challenges in Synthesis of Biologically Active Compounds

9. Pharmacokinetics and ADMET in Chemokine Receptor Drug Development

   • Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Profiles

   • Optimizing Drug Properties for Clinical Efficacy

   • Toxicological Considerations and Safety Assessment

Part IV: Clinical Applications and Future Directions

10. Chemokine Receptors in Cancer Therapy

    • Chemokine Receptors as Targets in Cancer Immunotherapy

    • Targeting Tumor Microenvironment and Immune Cell Infiltration

    • Current Clinical Trials and Drug Development

11. Chemokine Receptors in Inflammatory and Autoimmune Diseases

    • Targeting Chemokine Receptors for Chronic Inflammation

    • Chemokine Receptor Modulators in Diseases like Rheumatoid Arthritis and IBD

    • Clinical Evidence and Emerging Therapies

12. Chemokine Receptors in Infectious Diseases

    • Chemokine Receptor Targeting for HIV/AIDS and Other Viral Infections

    • Exploring the Role of Chemokine Receptors in Pathogen Entry

    • Developing Chemokine Receptor-Based Vaccines and Antivirals

13. Challenges in Developing Chemokine Receptor-Based Drugs

    • Selectivity and Off-Target Effects

    • The Blood-Brain Barrier and CNS-Targeted Therapies

    • Overcoming Resistance and Receptor Desensitization

14. The Future of Chemokine Receptor Drugs

    • Emerging Technologies in Drug Discovery

    • Personalized Medicine and Chemokine Receptor Targeting

    • Novel Therapeutic Strategies and Next-Generation Approaches

Conclusion

• Key Insights and Takeaways

• The Importance of Chemokine Receptors as Drug Targets

• Future Prospects in Drug Development and Therapeutic Applications

Appendices

• Appendix A: Glossary of Terms Related to Chemokine Receptors and Medicinal Chemistry

• Appendix B: Methods and Protocols for Chemokine Receptor Assays

• Appendix C: List of Chemokine Receptors and Their Functions in Human Diseases

• Index

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Martine J Smit,Sergio A Lira,Rob Leurs,Chemokine Receptors,Medicinal Chemistry