Chromosomal Instability and Aging Basic Science and Clinical Implications 1st Edition by Fuki Hisama, Sherman Weissman, George Martin 9780824747305 0824747305
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Product details:
ISBN 10: 0824747305
ISBN 13: 9780824747305
Author: Fuki M. Hisama, Sherman M. Weissman, George M. Martin
This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases
Table of contents:
1 Introduction
2 Overview of Chromosomal Instability and Aging Mechanisms
3 Cellular Senescence
4 Telomeric Shortening and Replicative Aging
5 Telomeric Regulation in Eukaryotic Cells
6 Role of Ku at the Telomere
7 Chromosomal Instability in Normative Aging
8 Chromatin, Aging, and Cellular Senescence
9 Werner Syndrome
10 Bloom Syndrome: Genetic, Cellular, and Molecular Features asCompared to Werner Syndrome
11 Molecular Biology ofRothmund-Thomson Syndrome
12 Hutchinson-Gilford Progeria Syndrome
13 Ataxia-Telangiectasia
14 Nijmegen Breakage Syndrome
15 Dyskeratosis Congenita
16 Genetic Instability and FanconiAnemia
17 Xeroderma Pigmentosum
18 Down Syndrome
19 Genomic Instability andYeast Aging
20 Genetics of Aging in the Nematode
21 Aging, Somatic Maintenance, and Genomic Stability in Drosophilamelanogaster
22 Telomerase-Deficient Mouse Model
23 Animal Models of Oxidative Stress and Aging
24 Conclusions and Future Directions
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Tags: Fuki Hisama, Sherman Weissman, George Martin, Chromosomal