Combinatorial Library Methods and Protocols 1st Edition by Lisa Bellavance English 1592592856 9781592592852

Combinatorial Library Methods and Protocols 1st Edition by Lisa Bellavance English – Ebook PDF Instant Download/Delivery: 1592592856, 9781592592852

Full download Combinatorial Library Methods and Protocols 1st Edition after payment

Product details:

ISBN 10: 1592592856 

ISBN 13: 9781592592852

Author: Lisa Bellavance English

By significantly increasing the number of targets available for drug discovery, the Human Genome and Proteome projects have made the use of combinatorial libraries essential to developing and optimizing drug candidate molecules more rapidly. Lisa English and a panel of expert researchers have collected in Combinatorial Library Methods and Protocols a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR. A variety of well-known computational approaches are provided to meet the information management challenge of multiple biological assays. Each readily reproducible technique includes detailed step-by-step instructions and helpful notes on troubleshooting and avoiding pitfalls. Timely and highly practical, Combinatorial Library Methods and Protocols makes available for all drug discovery researchers all the powerful combinatorial chemistry tools that are increasing the number of candidate compounds and speeding the process of drug discovery and development today.

Table of contents:

Pt. 1. Library Synthesis And Quality Control
Using A Noncovalent Protection Strategy To Enhance Solid-phase Synthesis / Fahad Al-obeidi
Quality Control Of Solid-phase Synthesis By Mass Spectrometry / Jean-Louis Aubagnac
Preparation Of Encoded Combinatorial Libraries For Drug Discovery / Tao Guo
Simple Tools For Manual Parallel Solid Phase Synthesis / Viktor Krchnak
Cleavage Of Compounds From Solid Phase By Gaseous Reagents / Viktor Krchnak
Synthesis Of DNA-binding Polyamides: Robust Solid-phase Methods For Coupling Heterocyclic Aromatic Amino Acids / Peter O. Krutzik
The Preparation Of Phenyl-stilbene Derivatives Using The Safety Catch Linker / Amy Lew
Host-guest Chemistry: Combinatorial Receptors / Brian R. Linton
Automated Structure Verification Of Small Molecule Libraries Using 1D And 2D NMR Techniques / Gerard Rosse
Rapid Liquid-phase Combinatorial Synthesis Of Heterocyclic Libraries / Chung-Ming Sun
Soluble Polymer-supported Methods For Combinatorial And Organic Synthesis / Paul Wentworth, Jr.
Analytical Methods For Optimization And Quality Control Of Combinatorial Synthesis / Bing Yan

Pt. 2. Library Purification And Screening
Resolving Racemic Mixtures Using Parallel Combinatorial Libraries / Tingyu Li
Ligand Libraries For The Extraction Of Metal Ions: Dynamic Combinatorial And High-throughput Screening Methods / Seema Choudhary
Automated Liquid-liquid Extraction And Ion-exchange Solid-phase Extraction For Initial Purification / Sean X. Peng
On-bead And Solution Screening Approaches For Genomically Derived Targets: Discovery Of Surrogate Ligands And Substrates Using Combinatorial Chemistry Libraries / David S. Thorpe

Pt. 3. Computational Library Design
Design Of Virtual Combinatorial Libraries / Alex M. Aronov
Approaches To Library Design For Combinatorial Chemistry / Stefan Güssregen
Reagent-based And Product-based Computational Strategies In Library Design / Eric A. Jamois
Designing Combinatorial Libraries For Efficient Screening / John I. Manchester
Application Of Neural Networks To Large Dataset QSAR, Virtual Screening, And Library Design / David A. Winkler

People also search:

combinatorial topology pdf

combinatorial analysis mit

combinatorial algorithms part 2

combinatorial analysis pdf

combinatorial approach

Tags: Lisa Bellavance English, Combinatorial, Library, Methods