Cyclic Nucleotide Phosphodiesterases in Health and Disease 1st Edition by Joseph Beavo, Sharron Francis, Miles Houslay 9780849396687 0849396689
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ISBN 10: 0849396689
ISBN 13: 9780849396687
Author: Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.Cyclic Nucleotide Phosph
Table of contents:
Chapter 1 Cyclic Nucleotide Phosphodiesterase Superfamily
Chapter 2 Phosphodiesterase Isoforms—An Annotated List
Section A Specific Phosphodiesterase Families—Regulation, Molecular and Biochemical Characteristics
Chapter 3 Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases
Chapter 4 PDE2 Structure and Functions
Chapter 5 Phosphodiesterase 3B: An Important Regulator of Energy Homeostasis
Chapter 6 Cellular Functions of PDE4 Enzymes
Chapter 7 Phosphodiesterase 5: Molecular Characteristics Relating to Structure, Function, and Regulation
Chapter 8 Photoreceptor Phosphodiesterase (PDE6): A G-Protein-Activated PDE Regulating Visual Excitation in Rod and Cone Photoreceptor Cells
Chapter 9 PDE7
Chapter 10 cAMP-Phosphodiesterase 8 Family
Chapter 11 PDE9
Chapter 12 PDE10A: A Striatum-Enriched, Dual-Substrate Phosphodiesterase
Chapter 13 PDE11
Section B Nonmammalian Phosphodiesterases
Chapter 14 Protozoal Phosphodiesterases
Chapter 15 Studies of Phosphodiesterase Function Using Fruit Fly Genomics and Transgenics
Section C Phosphodiesterases Functional Significance: Gene-Targeted Knockout Strategies
Chapter 16 Insights into the Physiological Functions of PDE4 from Knockout Mice
Chapter 17 Regulation of cAMP Level by PDE3B—Physiological Implications in Energy Balance and Insulin Secretion
Section D Compartmentation in Cyclic Nucleotide Signaling
Chapter 18 Heart Failure, Fibrosis, and Cyclic Nucleotide Metabolism in Cardiac Fibroblasts
Chapter 19 Role of A-Kinase Anchoring Proteins in the Compartmentation in Cyclic Nucleotide Signaling
Chapter 20 Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation in Cardiac Myocytes
Section E Phosphodiesterases as Pharmacological Targets in Disease Processes
Chapter 21 Role of PDEs in Vascular Health and Disease: Endothelial PDEs and Angiogenesis
Chapter 22 Regulation of PDE Expression in Arteries: Role in Controlling Vascular Cyclic Nucleotide Signaling
Chapter 23 Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases
Chapter 24 Role of Cyclic Nucleotide Phosphodiesterases in Heart Failure and Hypertension
Chapter 25 Molecular Determinants in Pulmonary Hypertension: The Role of PDE5
Chapter 26 Role of PDE5 in Migraine
Chapter 27 Phosphodiesterase-4 as a Pharmacological Target Mediating Antidepressant and Cognitive Effects on Behavior
Chapter 28 Role of Phosphodiesterases in Apoptosis
Section F Development of Specific Phosphodiesterase Inhibitors as Therapeutic Agents
Chapter 29 Crystal Structure of Phosphodiesterase Families and the Potential for Rational Drug Design
Chapter 30 Structure, Catalytic Mechanism, and Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases
Chapter 31 Bench to Bedside: Multiple Actions of the PDE3 Inhibitor Cilostazol
Chapter 32 Reinventing the Wheel: Nonselective Phosphodiesterase Inhibitors for Chronic Inflammatory Diseases
Chapter 33 Medicinal Chemistry of PDE4 Inhibitors
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Tags: Joseph Beavo, Sharron Francis, Miles Houslay, Nucleotide