Dendrimers in nanomedicine 1st Edition by Felder Flesch, Delphine ISBN 9814745502 9789814745505

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ISBN 10:  9814745502 
ISBN 13: 9789814745505
Author:  Felder Flesch, Delphine

Nanomedicine can take advantage of the recent developments in nanobiotechnology research for the creation of platforms with superior drug carrier capabilities, selective responsiveness to the environment, unique contrast enhancement profiles, and improved accumulation at the disease site. This book provides a broad glimpse of how various dendritic nanomaterials have been designed and used as efficient tools for nanomedicine. It comprises a pedagogic introduction to dendrimers and hyperbranched systems and their classical and accelerated syntheses through cutting-edge methodologies. The chapters on dendronized magnetic nanoparticles as theranostics, dendrimers in theory (molecular simulations), siRNA delivery with dendrimers, and dendrimers for image-guided therapy, combined with chapters focused on specific types of dendrimers or hyperbranched structures, detail the cutting-edge research in nanomedicine. Finally, a detailed chapter on issues related to the pharmacokinetics and biodistribution of dendrimers helps choose the right structures for successful transfer from bench to bedside. This book will appeal to those involved in nanobiotechnology, macromolecular science, cancer therapy, tissue repair, and siRNA delivery research.

Dendrimers in nanomedicine 1st Table of contents:

1. General Introduction on Dendrimers, Classical versus Accelerated Syntheses and Characterizations
1.1 General Introduction
1.2 Synthesis
1.2.1 Classical Synthesis Pathways
1.2.1.1 Divergent growth
1.2.1.2 Convergent growth
1.2.1.3 Orthogonal convergent growth
1.2.2 Accelerated Approaches
1.2.2.1 Double-stage convergent method or the hypercore approach
1.2.2.2 Hypermonomer method or the branched monomer approach
1.2.2.3 Double-exponential method
1.2.2.4 Orthogonal coupling method or the two-step approach, the two monomers approach, and the AB2–CD2 approach
1.2.2.5 Other accelerated strategies
1.3 Characterization
1.4 Conclusion
2. Dendrimer–Nanoparticle Conjugates in Nanomedicine
2.1 Introduction
2.2 Why Dendrimers and Dendrons?
2.3 Dendrimer NPs Conjugates
2.3.1 Gold Nanoparticles
2.3.2 Quantum Dots Dendritic Nanoboxes
2.3.3 Iron Oxide Nanoparticles
2.3.3.1 NPs synthesis
2.3.3.2 Synthesis of dendrons
2.3.3.3 Nanohybrids
2.3.3.4 In vivo applications
2.3.4 Up-Conversion NPs
2.3.5 Manganese Oxide NPs
2.4 Conclusion
3. Dendritic Polymers for the Repair of Tissues
3.1 Introduction
3.2 Synthesis and Properties of Dendritic Hydrogels
3.2.1 Physical Gelation
3.2.2 Chemical Gelation
3.3 Tissue Repair and Tissue Engineering Applications
3.3.1 Tissue Repair
3.3.2 Tissue Engineering
3.4 Conclusions
4. Polyglycerols in Nanomedicine
4.1 Introduction
4.2 Chemistry and Chemical Diversification of dPGs
4.2.1 Origin and Evolution of dPGs Structure
4.2.2 Chemistry of Linear PGs: Analogue Frequently Overlooked
4.2.3 Macromonomers of Linear PG: Building Complex Topology
4.2.4 Dendritic PGs: Branched Scaffold with Nanoscale Benefits
4.2.5 Well-Defined Hyperbranched PG: dPGs with Random Regularity
4.2.6 Core Variation of dPG Increases Functionality and Applicability
4.2.7 Block Copolymers of Dendritic Polyglycerol
4.2.8 Postpolymerization Modification: Tailoring the Properties of Polyglycerol
4.2.9 Giant Polyglycerols: Motifs Resulting in Megamers, Microgels, and Hydrogels
4.3 Forms Guiding Functions: Features of dPGs Architecture
4.4 Biocompatibility of Dendritic Polyglycerols
4.5 Nanomedical Applications of dPGs
4.5.1 Supramolecular Platforms of dPGs for Noncovalent Guest Encapsulation
4.5.2 Multifunctional dPG–drug Conjugates for Tumor Targeting
4.5.3 Designing Functional Architectures Based on PG for Multivalent Interaction
4.5.3.1 Neutral PGs as mimicry of oligosaccharides for surface modification
4.5.3.2 Negatively charged dPG derivatives
4.5.3.3 Applications of polycationic derivatives ofdendritic PGs
4.5.4 Polyglycerol Nanogel in Biomedicine
4.6 Opportunities
4.7 Conclusions
5. Theranostic Potential of Dendronized Iron Oxide Nanoparticles
5.1 Introduction
5.2 Influence of the NPs Synthesis Way and of the Functional Peripheral End Groups on the Grafting Conditions and Colloidal Stability
5.3 MRI Properties of Dendronized Iron Oxide NPs
5.4 Mastering Shape and Composition of Dendronized Iron Oxide Nanoparticles to Tailor Magnetic Hyperthermia Properties
5.5 Conclusion
6. Anti-Inflammatory Dendrimers
6.1 Introduction
6.2 Cargo-Loading Strategy: Association of Anti-Inflammatory Drugs with Dendrimers
6.2.1 Non-Targeted Strategies
6.2.1.1 Drug-dendrimer interactions
6.2.1.2 Surface-modified and core-modified dendrimers
6.2.1.3 In vivo validation of cargo-loading strategies
6.2.2 Targeted Strategies
6.3 Prodrug Strategy: Conjugation of Anti-Inflammatory Drugs on Dendrimers
6.3.1 Dendrimer-NSAI Drug Conjugates
6.3.2 Controlled Release of N-Acetyl-Cysteine with Dendrimer Conjugates
6.3.3 Glucosamine-Terminated Dendrimers
6.3.4 Dendrimer-Corticoid Conjugates
6.3.5 Targeted Strategies and Covalent Grafting
6.4 Dendrimers Showing Anti-Inflammatory Properties per se
6.4.1 Carbosilane Dendrimers
6.4.2 PPH Dendrimers
6.4.3 Other Examples
6.4.3.1 PAMAM
6.4.3.2 Click dendrimers
6.5 Conclusions and Perspectives
7. Structurally Flexible and Amphiphilic Poly(Amidoamine) Dendrimers as Nonviral Vectors for siRNA Delivery
7.1 Introduction
7.2 Structurally Flexible TEA-Core PAMAM Dendrimers
7.3 Amphiphilic PAMAM Dendrimers
7.4 Conclusion and Prospects
8. Dendrimers as Nanomedicine in Cancer Therapy
8.1 Introduction
8.2 Cancer Targeted Drug Delivery
8.3 Gene Therapy: Cancer
8.4 Brain Delivery
8.5 Dendrimer Hybrids with Other Nanomaterials in Cancer Therapy
8.6 Theranostic Applications
8.7 Future Prospects
8.8 Conclusion
9. Impact of Physicochemical Properties on Dendrimer Pharmacokinetics and Biodistribution
9.1 Introduction
9.2 Understanding Pharmacokinetics
9.3 Intravenous Pharmacokinetics
9.3.1 Introduction
9.3.2 Effect of Size
9.3.3 Effect of Surface Charge
9.3.4 Effect of Drug Loading
9.3.5 Effect of Structural Flexibility
9.4 Tumor Biodistribution
9.4.1 Passive Tumor Targeting
9.4.2 Active Tumor Targeting
9.5 Subcutaneous Pharmacokinetics
9.5.1 Introduction
9.5.2 Structure of the Interstitial Space
9.5.3 Impact of Dendrimer Size on Absorption from Subcutaneous Injection Sites
9.5.4 Impact of Surface Charge on Subcutaneous Absorption
9.6 Oral Pharmacokinetics
9.7 Transdermal Pharmacokinetics
9.8 Pulmonary Pharmacokinetics
9.9 Conclusion
10. Molecular Modeling of Dendrimers
10.1 Summary
10.2 Introduction
10.2.1 Dendrimers and Their Applications
10.2.2 Limits of the Experiments in the Characterization of Dendrimers and the Potential of Molecular Modeling
10.3 Molecular Modeling of Dendrimers
10.3.1 First Dendrimers Models
10.3.2 Atomistic Simulation of dendrimers in the Gas-Phase
10.3.3 Characterization of the Dendrimers in Solution
10.3.4 Coarse Graining
10.3.5 Advanced Sampling Techniques: Metadynamics
10.4 Some Practical Applications of Molecular Modeling in the Field of Dendrimers
10.4.1 Dendritic Host for Small Hydrophobic Guests: Accessibility to the Dendrimer’s Interior
10.4.2 Dendrimers’ Flexibility
10.4.3 Dendrimers Self-Assembly Solution
10.4.4 Dendrimers Aggregates Responsive to External Stimuli
10.5 Conclusions and Future Perspectives

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Tags: Felder Flesch, Delphine, nanomedicine, Dendrimers