Development of Auditory and Vestibular Systems 3 Molecular Development of the Inner Ear 1st Edition by Raymond Romand, Isabel Varela Nieto ISBN 0080490913 9780080490915

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Product details:

ISBN 10: 0080490913

ISBN 13: 9780080490915

Author:  Raymond Romand, Isabel Varela-Nieto 

Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear 1st Edition: Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research to show how the discovery of more genes involved in the development of the inner ear leads to the generation of new models that examine a wealth of issues — from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation. The wide variety of experimental approaches will help readers to understand the broad range of issues related to inner ear morphogenesis and other concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike.

* Scores of high-quality, full- color figures
* Detailed schemes on the structure and timing of ear development
* Current Topics in Developmental Biology is the longest-running forum for contemporary issues in developmental biology

 

Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear 1st Edition Table of contents:

Chapter 1. Molecular Conservation and Novelties in Vertebrate Ear Development

• I. Introduction
• II. Overview of Ideas Related to Ear Evolution
• III. Making the Ear: Implementing and Expanding Genes for Ear Morphogenesis
• IV. Evolution of the Ear: Molecular Origin of Mechanosensory Cells Predates Formation of the Ear
• V. Developmental Molecular Biology of Hair Cell and Sensory Neuron Formation
• VI. Evolution of Sensory Neurons: Heterochronic Alteration of HLH Gene Regulation
• VII. Guidance of Afferent Fibers: The Role of Hair Cells and Other Mechanisms Revisited
• VIII. Survival of Afferents: Evolving a Novel Mechanism and Expanding it to Fit the Increasing Complexity
• IX. Splitting Hair Cell and Neuron Populations: Coevolving Sensory Epithelia and Their Innervation
• X. Summary and Conclusions: Evolving Developmental Mechanisms
• Acknowledgments
• References

Chapter 2. Use of Mouse Genetics for Studying Inner Ear Development

• I. Introduction: The Genetic Revolution
• II. Early Morphogenesis of the Inner Ear
• III. Development of the Neuroepithelium
• IV. Concluding Remarks
• References

Chapter 3. Formation of the Outer and Middle Ear, Molecular Mechanisms

• I. Introduction
• II. Basic Anatomical and Embryological Overview
• III. Genetic Determinants of Outer and Middle Ear Development
• IV. Concluding Remarks
• References

Chapter 4. Molecular Basis of Inner Ear Induction

• I. Introduction
• II. Inner Ear Induction in Fish
• III. Inner Ear Induction in Amphibians
• IV. Inner Ear Induction in Birds
• V. Inner Ear Induction in Mammals
• VI. Perspectives on Inner Ear Induction
• VII. Conclusions
• Acknowledgments
• References

Chapter 5. Molecular Basis of Otic Commitment and Morphogenesis

• I. Introduction
• II. Patterning of the Inner Ear Anlagen
• III. Transcription Factors and Diffusible Signals: A Complex Network
• IV. Patterning and Morphogenesis
• V. Conclusions
• Acknowledgments
• References

Chapter 6. Growth Factors and Early Development of Otic Neurons

• I. Introduction
• II. Early Development of Cochlear (Auditory) and Vestibular Neurons
• III. Extrinsic Factors in Inner Ear Neurogenesis: Fibroblast Growth Factor, Nerve Growth Factor, and Others
• IV. Conclusions
• Acknowledgments
• References

Chapter 7. Neurotrophic Factors during Inner Ear Development

• I. Neurotrophic Factors
• II. The Neurotrophin System
• III. The Glial Cell Line–Derived Neurotrophic Factor Family
• IV. Conclusions
• Acknowledgment
• References

Chapter 8. FGF Signaling in Ear Development and Innervation

• I. Introduction
• II. Fibroblast Growth Factor Signaling in Ear Development
• III. Conclusions and Future Directions
• Acknowledgments
• References

Chapter 9. The Roles of Retinoic Acid during Inner Ear Development

• I. Introduction
• II. Metabolism of Retinoids and Their Receptors
• III. Expression of Retinoic Acid Metabolic Enzymes and Receptors in the Developing Inner Ear
• IV. Is Retinoic Acid Involved in Otic Placode Induction?
• V. Retinoids as Morphogens during Early Embryogenesis
• VI. Retinoic Acid and Patterning Genes during Inner Ear Development
• VII. Retinoic Acid and Hair Cell Differentiation
• VIII. Concluding Remarks
• Acknowledgment
• References

Chapter 10. Hair Cell Development in Higher Vertebrates

• I. Morphogenesis of the Mammalian Inner Ear
• II. Control of Hair Cell Differentiation by Specific Genes
• III. Production and Regeneration of New Hair Cells in Mature Inner Ears
• IV. Conclusion
• Acknowledgments
• References

Chapter 11. Cell Adhesion Molecules during Inner Ear and Hair Cell Development

• I. Introduction
• II. Adhesion Molecules
• III. Adhesion Molecules and Development of the Inner Ear
• IV. Summary
• Acknowledgments
• References

Chapter 12. Genes Controlling the Development of the Zebrafish Inner Ear and Hair Cells

• I. Introduction
• II. General Course of Zebrafish Otic Development
• III. Otic Induction
• IV. Patterning of the Placode and Early Vesicle
• V. Development of Sensory Epithelia
• VI. Auditory and Vestibular Function
• VII. Conclusions and Prospects
• References

Chapter 13. Functional Development of Hair Cells

• I. Introduction
• II. Maturation of Function
• III. Development of Mechanoelectrical Transduction
• IV. Developmental Acquisition of Basolateral Ion Channels
• V. Outer Hair Cell Electromotility
• VI. Interactions between Developing Hair Cells and Innervating Nerve Fibers
• VII. Summary and Concluding Remarks
• Acknowledgments
• References

Chapter 14. The Cell Cycle and the Development and Regeneration of Hair Cells

• I. Introduction
• II. The Cell Cycle and the Regulation of Cell Proliferation
• III. Hair Cell Development and Regeneration
• IV. Cell Cycle Events during Hair Cell Development
• V. The Cell Cycle during Hair Cell Regeneration
• VI. Conclusions

 

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