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Epilepsy Infantile Spasms and Development Encephalopathy 1st Edition by Philip Schwartzkroin, Jong Rho 0123668492 9780123668493

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Epilepsy Infantile Spasms and Development Encephalopathy 1st Edition Philip A. Schwartzkroin Digital Instant Download

Author(s): Philip A. Schwartzkroin, Jong M. Rho (Eds.)
ISBN(s): 9780123668493
Edition: 1st
File Details: PDF, 49.84 MB
Year: 2002
Language: english
SKU: EB-2168904 Category: Tags: ,

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ISBN 10: 0123668492

ISBN 13: 9780123668493 

Author: Philip A. Schwartzkroin, Jong M. Rho

 

Epilepsy, Infantile Spasms, and Developmental Encephalopathy explores the nature and bases of infantile spasms – a major representative of the catastrophic developmental seizure disorders seen in early childhood. Although this topic has received considerable attention as a clinical disorder, the underlying pathogenesis of infantile spasms remains poorly understood. The aim is not simply to describe and label the clinical phenomenology associated with infantile spasms, but rather to work toward an understanding of the underlying mechanisms and of effective treatment strategies. The result is a volume with a high density of exciting ideas that can be taken to the bedside or to the laboratory for further study.

Approaching the subject from an interdisciplinary perspective, this book integrates clinical and basic science in its discussion of infantile spasms as representative of a common developmental brain disorder. It also provides experimentally testable hypotheses to direct further research, and presents reviews of the literature associated with suggested underlying mechanisms.

Epilepsy, Infantile Spasms, and Developmental Encephalopathy explores the nature and bases of infantile spasms – a major representative of the catastrophic developmental seizure disorders seen in early childhood. Although this topic has received considerable attention as a clinical disorder, the underlying pathogenesis of infantile spasms remains poorly understood. The aim is not simply to describe and label the clinical phenomenology associated with infantile spasms, but rather to work toward an understanding of the underlying mechanisms and of effective treatment strategies. The result is a volume with a high density of exciting ideas that can be taken to the bedside or to the laboratory for further study.

Epilepsy Infantile Spasms and Development Encephalopathy 1st Table of contents:

Editorial Board

Contributors

Preface

What is West Syndrome?

Relationship Between Encephalopathy and Abnormal Neuronal Activity in the Developing Brain

Hypotheses from Functional Neuroimaging Studies

Infantile Spasms: Unique Syndrome or General Age-Dependent Manifestation of a Diffuse Encephalopathy?

Histopathology of Brain Tissue from Patients with Infantile Spasms

Generators of Ictal and Interictal Electroencephalograms Associated with Infantile Spasms

Cortical and Subcortical Generators of Normal and Abnormal Rhythmicity

Role of Subcortical Structures in the Pathogenesis of Infantile Spasms

What Must We Know to Develop Better Therapies?

Treatment of Infantile Spasms: An Evidence-Based Approach

ACTH Treatment of Infantile Spasms: Mechanisms of Its Effects in Modulation of Neuronal Excitability

Neurosteroids and Infantile Spasms: The Deoxycorticosterone Hypothesis

Are There Specific Anatomical and/or Transmitter Systems That Should Be Targeted?

Medical Versus Surgical Treatment: Which Treatment When?

Developmental Outcome with and without Successful Intervention

Infantile Spasms Versus Myoclonus: Is There a Connection?

Tuberous Sclerosis as an Underlying Basis for Infantile Spasms

Brain Malformations, Epilepsy, and Infantile Spasms

Brain Maturational Aspects Relevant to Pathophysiology of Infantile Spasms

Gene Expression Analysis as a Strategy to Understand the Molecular Pathogenesis of Infantile Spasms

Infantile Spasms: Criteria for an Animal Model

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Philip Schwartzkroin,Jong Rho,Epilepsy,Infantile