Foundations of comparative genomics 1st Edition by Arcady Mushegian 0120887940 9780120887941
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Product details:
ISBN 10: 0120887940
ISBN 13: 9780120887941
Author: Arcady R. Mushegian
This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics.
Table of contents:
Chapter 1: The Beginning of Computational Genomics
Chapter 2: Finding Sequence Similarities
Chapter 3: Homology: Can We Get It Right?
Glossary
Chapter 4: Getting Ready fot the Era of Comparative Genomics: The Importance of Viruses
Chapter 5: The First Fact of Comparative Genomics: Protein Sequences are Remarkably Resilient in Evo
Chapter 6: The Second Fact of Comparative Genomics: Functional Convergence at the Molecular Level
Chapter 7: Prediction of Function and Reconstruction of Metabolism from Genomic Data: Homology-Based
Chapter 8: Prediction of Function and Reconstruction of Metabolism: Post-Homology Approaches
Chapter 9: Structural Genomics:What Does It Tell Us about Life?
Chapter 10: How Many Protein Families are There?
Chapter 11: Phylogenetic Inference and the Era of Complete Genomes
Chapter 12: Two Stories about Evolution
Chapter 13: Minimal and Ancestral Genomes
Chapter 14: Comparative Genomics and Systems Biology
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Tags: Arcady Mushegian, Foundations, comparative, genomics