Growing bone 2nd Edition by James F Whitfield ISBN 1435602447 9781435602441

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ISBN 10: 1435602447 
ISBN 13: 9781435602441
Author: James F Whitfield

Growing numbers of men and many more women are suffering from crippling bone loss called osteoporosis. By 2050 50% of Americans over 50 will be at risk of, or actually have, osteoporosis. In this book the reader will meet the newest real and possible bone builders and learn how they might work. These include novel steroids, an osteogenic growth pep

Growing bone 2nd Table of contents:

1. What Is Osteoporosis?
2. BMUS—The Microcrack Fixers
i. Strains, Microcracks, Macrocracks and Molecular Screams
ii. Calling the Diggers
iii. The Arrival at the Work Site
iv. Osteoclasts and the Dead Bone Puzzle
v. The Fillers
vi. The Decline and Fall of Bone Strength and BMU Efficiency but a Rise in Remodeling Rate and Cortical Porosity with Age
3. Menopause and Bone Loss
i. Leptin, Fat, Brains and Bones
ii. How Does an Estrogen Loss Cause a Bone-Wasting Osteoclast Population Explosion?
iii. How to Stop (or at Least Slow) Menopausal Bone Loss
4. The Amazing Bone-Anabolic PTHs
i. Anabolics—The Answers to the Osteoporotics’ Prayers
ii. The Ancient Origins of PTH and Its Receptor
iii. PTHs-Induce Bone Growth and Fracture Mending in Non-Human Animals
iv. PTHs-Induced Bone Growth in Humans
v. Rat versus Human—Problems for Extrapolation and Prediction
5. How Might PTHs Stimulate Bone Growth?
i. The Starter Gun: The PTHR1 Receptor
ii. What Signal Bullets Switch on the Bone-Making Machine?
iii. PTHs Speak To Bones with Two-Pronged Forked Tongues—One Prong Says Make It!
iv. PTHs Speak To Bones with Two-Pronged Forked Tongues—The Other Prong Says Remove It!
v. How an Odd Couple—PTHrP and an Indian Hedgehog Build Bones
vi. A Brief PTHrP-Sponsored Side-Trip to the Skin
vii. PTHs and Rheumatoid Arthritis
viii. PTHs and Cancer—A Concern with All Growth Stimulators
ix. A Possible Threat
x. PTHrP, PTHR1 Receptors and Stroke
xi. Grand Summary
6. The Clinical Prospects of the Invincible PTHs
7. OGP—The Osteogenic Growth Peptide
8. The Statins
i. Animal Studies
ii. Osteogenic Mechanism
iii. Human Studies
iv. Statins and Alzheimer’s Disease
v. Statins’ Clinical Prospects
9. Surface Signaling Steroids—Real Anabolics or Pseudo-Anabolics?
i. Vitamin Ds
ii. Unisex Steroids
10. Strontium, Calcium’s Big Brother
11. Afterword

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