Handbook of Cancer Vaccines 1st Edition by Michael Morse, Timothy Clay, Kim Lyerly 1588292096 9781588292094

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Product details:

ISBN 10: 1588292096

ISBN 13: 9781588292094

Author: Michael A. Morse, Timothy M. Clay, H. Kim Lyerly

An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

Table of contents:

I: Basic Science of Tumor Antigens and Immune Activation

1. Biology of the Cancer Vaccine Immune Response

2. The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity

3. Identification of Tumor Antigens Using Subtraction and Microarrays

4. Tumor Antigen Discovery With T Cells

5. Targeting Viral Antigens for the Treatment of Malignancies

6. Immune Defects in Cancer

7. Escape of Tumors From the Immune System: Role of the Transforming Growth Factor-ß-Signaling Pathway

II: General Vaccine and Immunotherapy Strategies
8. Immune Adjuvants
9. Heterologous Prime-Boost Vaccination in Tumor Immunotherapy
10. Peptide-Based Vaccines
11. Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens
12. Anti-Idiotype Vaccines
13. Pox Viral Vaccines
14. Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches
15. Alphaviral-Based Strategies for the Immunotherapy of Cancer
16. DNA Vaccines
17. Whole-Cell Vaccines
18. Gene-Modified Tumor-Cell Vaccines
19. Hapten-Modified Tumor Vaccines
20. Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines
21. Dendritic Cell Vaccines
22. Exosomes for Immunotherapy of Cancer
23. Immunocytokines for Cancer Immunotherapy
24. T-Cell Adoptive Immunotherapy

III: Tumor-Specific Vaccine Development
25. Melanoma Vaccines
26. Allogenic Melanoma Lysate Vaccines
27. Renal Cancer Vaccines
28. Vaccines for Hematological Malignancies
29. Vaccines for the Immunotherapy of Prostate Cancer
30. Vaccine Therapy for Breast and Ovarian Cancers
31. Vaccine Therapy for Gastrointestinal Cancers
32. Vaccines for Lung Cancer
33. Vaccines for Other Tumors

IV: Clinical Trials and Immune Analyses
34. Clinical Trial Designs for Therapeutic Vaccine Studies
35. Analysis of Cellular Immune Responses in Cancer Vaccine Trials
36. Analysis of Humoral Immune Responses in Vaccine Trials
37. Regulatory Issues Affecting Tumor Vaccines

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Tags: Michael Morse, Timothy Clay, Kim Lyerly, Cancer