Handbook of Drug Screening 1st Edition by Ramakrishna Seethala, Prabhavathi Fernandes ISBN 0824705629 9780824705626

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ISBN 10: 0824705629 
ISBN 13: 9780824705626
Author: Ramakrishna Seethala, Prabhavathi Fernandes

Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery. With extensively updated content and 21 new chapters, this text examines:quality and efficiency of drug target validati

Handbook of Drug Screening 1st Table of contents:

1. Key Factors for Successful High-Throughput Screening
2. Critical Components in High-Throughput Screening: Challenges and New Trends
3. Hit-to-Probe-to-Lead Optimization Strategies: A Biology Perspective to Conquer the Valley of Death
4. Signal Detection Platforms for Screening in Drug Discovery
5. Proteomic Analysis in Drug Discovery
6. Screening and Characterization of G-Protein-Coupled Receptor Ligands for Drug Discovery
7. Nuclear Hormone Receptor Screening in Drug Discovery
8. Emerging Novel High-Throughput Screening Technologies for Cell-Based Assays
9. In Vitro Strategies for Ion Channel Screening in Drug Discovery
10. Wheat from Chaff: General and Mechanistic Triage of Screening Hits for Enzyme Targets
11. Protein Kinases and Phosphatases
12. MicroRNA Strategies in Drug Discovery
13. Strategies for Screening of Biologic Therapeutics
14. Cryopreserved Cells in Functional Cell-Based HTS Assays
15. High-Content Screening with a Special Emphasis on Cytotoxicity and Cell Health Measurements
16. Effective Application of Drug Metabolism and Pharmacokinetics in Drug Discovery
17. Compound Management for Drug Discovery: An Overview
18. Practical Approach to Quantitative High Throughput Screening
19. Enabling the Large-Scale Analysis of Quantitative High-Throughput Screening Data
20. Application of Nanobiotechnologies for Drug Discovery

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