Handbook of Radiotherapy Physics Theory and Practice 1st Edition by P Mayles, A Nahum, J C Rosenwald ISBN 1420012029 9781420012026

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ISBN 10: 1420012029 
ISBN 13: 9781420012026
Author: P Mayles, A Nahum, J C Rosenwald

From background physics and biological models to the latest imaging and treatment modalities, the Handbook of Radiotherapy Physics: Theory and Practice covers all theoretical and practical aspects of radiotherapy physics.

In this comprehensive reference, each part focuses on a major area of radiotherapy, beginning with an introduction by the editors and then subdividing into self-contained chapters. The first three parts present the fundamentals of the underlying physics, radiobiology, and technology involved. The ensuing sections discuss the support requirements of external beam radiotherapy, such as dose measurements, properties of clinical beams, patient dose computation, treatment planning, and quality assurance, followed by a part that explores exciting new advances that include developments in photon and particle therapy. Subsequent sections examine brachytherapy using sealed and unsealed sources and provide the framework of radiation protection, including an appendix that describes the detailed application of UK legislation. The final part contains handy tables of both physical constants and attenuation data.

To achieve safe and effective radiotherapy, there needs to be a close understanding among various disciplines. With contributions from renowned specialists, the Handbook of Radiotherapy Physics: Theory and Practice provides essential theoretical and practical knowledge for medical physicists, researchers, radiation oncologists, and radiation technologists.

Handbook of Radiotherapy Physics Theory and Practice 1st Table of contents:

Part A: Fundamental Physics

• Chapter A1: Basic Physics Concepts
  • (Covers atomic structure, quantum mechanics, nuclear physics, electromagnetism, special relativity.)
• Chapter A2: Interactions of Radiation with Matter
  • (Photon interactions: photoelectric effect, Compton scattering, pair production. Charged particle interactions: stopping power, range, Bragg peak. Neutron interactions.)
• Chapter A3: Radiation Quantities and Units
  • (Definitions of dose, exposure, kerma, fluence, absorbed dose, equivalent dose, effective dose, and their units.)
• Chapter A4: Radiation Detection and Measurement
  • (Ionization chambers, scintillation detectors, semiconductor detectors, film, thermoluminescent dosimeters (TLDs), optically stimulated luminescence (OSL) dosimeters.)

Part B: Radiobiology and Clinical Aspects

• Chapter B1: Basic Radiobiology
  • (Cell survival curves, four Rs of radiobiology, dose fractionation, hypoxia, oxygen enhancement ratio (OER), linear-quadratic model.)
• Chapter B2: Tissue and Organ Tolerance
  • (Normal tissue reactions, organ tolerance doses, dose-volume histograms (DVHs), serial vs. parallel organs.)
• Chapter B3: Clinical Oncology
  • (Principles of cancer treatment, staging, common cancers, multidisciplinary team approach.)

Part C: External Beam Radiotherapy Equipment

• Chapter C1: Kilovoltage X-ray Units
  • (Physics and design of superficial and orthovoltage machines.)
• Chapter C2: Linear Accelerators (Linacs)
  • (Components, operation, beam characteristics, accessories.)
• Chapter C3: Cobalt-60 Teletherapy Units
  • (Design and characteristics of Co-60 units.)
• Chapter C4: Simulators and CT Simulators
  • (Principles and use in treatment planning.)
• Chapter C5: Treatment Room Design and Shielding
  • (Layout, radiation safety, shielding calculations.)

Part D: Dosimetry and Calibration

• Chapter D1: Absolute Dosimetry
  • (Primary standards, calorimetry, Fricke dosimetry, graphite calorimetry.)
• Chapter D2: Secondary Standards and Calibration Protocols
  • (Code of practice, phantom dosimetry, measurement of beam data.)
• Chapter D3: Relative Dosimetry
  • (Percentage depth doses, tissue-phantom ratios, beam profiles, output factors.)
• Chapter D4: Monte Carlo Methods in Radiotherapy Dosimetry
  • (Principles, applications, advantages, and limitations.)

Part E: Treatment Planning

• Chapter E1: Image Acquisition for Treatment Planning
  • (CT, MRI, PET, fusion imaging.)
• Chapter E2: Target Volume Definition and Delineation
  • (GTV, CTV, PTV, OARs, ICRU reports.)
• Chapter E3: Dose Calculation Algorithms
  • (Photon dose calculation: algorithms from simple to advanced (e.g., Clarkson, convolution/superposition, Monte Carlo). Electron dose calculation.)
• Chapter E4: Treatment Planning Systems (TPS)
  • (Features, algorithms, quality assurance.)
• Chapter E5: Plan Evaluation and Optimization
  • (DVH analysis, conformity, homogeneity, biological dose models.)

Part F: Special Techniques and Modalities

• Chapter F1: Intensity-Modulated Radiation Therapy (IMRT)
  • (Principles, inverse planning, delivery techniques, QA.)
• Chapter F2: Image-Guided Radiation Therapy (IGRT)
  • (Imaging modalities, motion management, adaptive RT.)
• Chapter F3: Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiation Therapy (SBRT)
  • (Principles, techniques, delivery platforms, QA.)
• Chapter F4: Brachytherapy
  • (Principles, sources, dose calculation, HDR, LDR, permanent implants, applicator types, QA.)
• Chapter F5: Proton and Heavy Ion Therapy
  • (Physics, biological advantages, beam delivery, treatment planning.)
• Chapter F6: Total Body Irradiation (TBI) and Total Skin Electron Irradiation (TSEI)
  • (Techniques and dosimetry.)

Part G: Quality Assurance (QA) and Safety

• Chapter G1: Linac QA

  • (Daily, weekly, monthly, annual QA procedures.)

• Chapter G2: TPS QA

  • (Commissioning, verification, routine checks.)

• Chapter G3: Patient-Specific QA

  • (Pre-treatment verification, in vivo dosimetry.)

• Chapter G4: Radiation Protection and Safety

  • (Regulatory frameworks, occupational exposure, public safety, accidental exposure management.)

• Chapter G5: Error Management and Reporting

  • (Risk management, incident learning systems.)

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