Handbook of Traumatic Brain Injury and Neurodegeneration 1st Edition by Rudy Castellani 9781643680644 1643680641
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ISBN 10: 1643680641
ISBN 13: 9781643680644
Author: Rudy J Castellani
Holbourne’s theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk’ syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field.
Table of contents:
Chapter 1: Long-Term Neurological Consequences Related to Boxing and American Football: A Review of the Literature
Chapter 2: Dementia Pugilistica Revisited
Chapter 3: Assessing the Limitations and Biases in the Current Understanding of Chronic Traumatic Encephalopathy
Chapter 4: The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features
Chapter 5: Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges
Chapter 6: Chronic Traumatic Encephalopathy and Neurodegeneration in Contact Sports and American Football
Chapter 7: The Neuropathological and Clinical Diagnostic Criteria of Chronic Traumatic Encephalopathy: A Critic
Chapter 8: No Evidence of Chronic Traumatic Encephalopathy Pathology or Increased Neurodegenerative Proteinopathy
Chapter 9: What is the Relationship of Traumatic Brain Injury to Dementia?
Chapter 10: Brain Injury in the Context of Tauopathies
Chapter 11: Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury
Chapter 12: Brain Injury and Later-Life Cognitive Impairment and Neuropathology: The Honolulu-Asia Aging Study
Chapter 13: Head Trauma and Alzheimer’s Disease: A Case Report and Review of the Literature
Chapter 14: Traumatic Brain Injury and Risk of Long-Term Brain Changes, Accumulation of Pathological Markers, and Cognitive Decline
Chapter 15: Traumatic Brain Injury and Age of Onset of Dementia with Lewy Bodies
Chapter 16: Prevalence of Traumatic Brain Injury in Early Versus Late-Onset Alzheimer’s Disease
Chapter 17: Autonomic Nervous System Dysfunctions as a Basis for a Predictive Model of Risk of Neurological Disorders
Chapter 18: Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Onset
Chapter 19: Traumatic Brain Injury and Suicidal Behavior: A Review
Chapter 20: Elevated Plasma MCP-1 Concentration Following Traumatic Brain Injury as a Potential “Predisposition”
Chapter 21: Decreased Level of Olfactory Receptors in Blood Cells Following Traumatic Brain Injury and Potential Implications
Chapter 22: The Influence of the Val66Met Polymorphism of Brain-Derived Neurotrophic Factor on Neurological Function
Chapter 23: Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer’s Disease: Common Pathologies
Chapter 24: Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes
Chapter 25: Paclitaxel Reduces Brain Injury from Repeated Head Trauma in Mice
Chapter 26: Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer’s Disease
Chapter 27: VEGF-C Induces Alternative Activation of Microglia to Promote Recovery from Traumatic Brain Injury
Chapter 28: Perfusion Neuroimaging Abnormalities Alone Distinguish National Football League Players from a Healthy Cohort
Chapter 29: White Matter and Cognition in Traumatic Brain Injury
Chapter 30: MRI Volumetric Quantification in Persons with a History of Traumatic Brain Injury and Cognitive Impairment
Chapter 31: FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy
Chapter 32: Inflammation in Traumatic Brain Injury
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Tags: Rudy Castellani, Handbook, Traumatic, Neurodegeneration