Hemodiafiltration a New Era 1st Edition by Kawanishi, Yamashita 3805595611 9783805595612
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ISBN 10: 3805595611
ISBN 13: 9783805595612
Author: H. Kawanishi, A. C. Yamashita
Hemodiafiltration (HDF) for the treatment of end-stage renal disease patients is predominantly performed in European countries and in Japan, with some differences in technique such as rate of blood flow and dialysis fluid delivery systems. The main focus of this book is on the clinical importance of online HDF, the techniques of which have been re-evaluated with the introduction of super high-flux membrane dialyzers. After a brief introduction into the history of HDF, recent advances and clinical experiences of HDF are summarized, including water quality control for dialysis fluid, equipped system for safe use, clinical advantages, and theoretical aspects of HDF. Moreover, at the end of each chapter researchers and scientists discuss problems into which further research is needed. Clinicians and scientists involved in the treatment of end-stage renal disease patients will find this publication an essential source of information. Moreover, it may also serve as a textbook for those who are planning to start HDF in their clinics or who are studying blood purification therapies in medical schools, nursing schools and even in engineering schools related to medical technologies.
Table of contents:
Hemodiafiltration: From Origin to Today
Techniques of Hemodiafiltration
Mechanism of Hemodiafiltration
Clinical Outcomes Achieved by HDF
Conclusion
References
Optimal Therapeutic Conditions for Online Hemodiafiltration
Abstract
Technical Prerequisite and Basic Hygienic Rules for ol-HDF
Prerequisite and Technical Options of ol-HDF
Vascular Access
Hemodiafilter
ol-HDF Prescription in Practice
Handling and Microbial Monitoring of ol-HDF
Conclusions
References
Effect of Hemodiafiltration on Mortality, Inflammation and Quality of Life
Abstract
Mortality
Inflammation
C-Reactive Protein (CRP)
Interleukin 6 (IL-6)
Health-Related Quality of Life
Treatment Optimization Parameters
Conclusion
References
How to Prescribe Hemodialysis or Hemodiafiltration in Order to Ameliorate Dialysis-Related Symptoms and Complications
Abstract
Classical Parameters for Prescribing a Dialysis Modality
New Concept for Prescribing a Dialysis Modality
Results of the Dialysis Prescription Based on the POD System
Rationale of the New Concept for a Dialysis Prescription
Solute Removal Pattern and Nutritional Advantage
BiocompatibilityofDialyzers
Dialysis Fluid Quality and Clinical Effects of Online HDF
The Advantage of Predilution HDF
Practice Pattern for Prescribing Online HDF from a Case Study (table 1)
Conclusion
References
Optimizing Home Dialysis: Role of Hemodiafiltration
Abstract
Benefits of HDF over Low-Flux and High-Flux Hemodialysis
Individualizing Choice of Renal Replacement Therapy
Providing HDF at Home: Technical Considerations
Dialysis Adequacy for Home HDF
Equipment Portability
Conclusion
Acknowledgement
References
Quality Management of Dialysis Fluid for Online Convective Therapies
Abstract
Online Preparation of Substitution Solution for Convective Therapies
Components of a Quality Management System
System Design
System Installation and Operational Verification
System Maintenance
System Monitoring
References
Biocompatibility of Dialysis Fluid for Online HDF
Abstract
Purification of Online Preparation
Composition of Dialysis and Substitution Fluids
Electrolytes
Glucose
Buffer
Methods
Patients
Conditions and Procedure for Online HDF
In vitro Study
Statistical Analysis
Results
Online HDF Study
In vitro Study
Discussion
Conclusion
References
Characteristics of Central Dialysis Fluid Delivery System and Single Patient Dialysis Machine for HDF
Abstract
Central Dialysis Fluid Delivery System in Japan
SPDM in Japan
Substitution Fluid for Online HDF with CDDS and SPDM
Maintenance of Purification of Dialysis Fluid
HD and/or Online HDF Using SPDM by Comprehensive Management
Conclusion
References
Fully Automated Dialysis System for Online Hemodiafiltration Built into the Central Dialysis Fluid Delivery System
Abstract
Outline of the Central Dialysis Delivery System
FADS with Online HDF
Fully Automated Dialysis System
Dialysis Fluid Quality Control Standards
Fluid Quality Control Method
Discussion
References
New Uremic Toxins – Which Solutes Should Be Removed?
Abstract
Toxicity of Specific Uremic Retention Solutes
Protein-Bound Solutes
p-Cresylsulfate
Homocysteine (Hcy)
Indoxylsulfate (IS)
Phenylacetic Acid (PAA)
Guanidines
Middle Molecules
Advanced Glycation End-Products (AGEs)
Dinucleoside Polyphosphates
Resistin
Removal of Protein-Bound Uremic Solutes and Middle Molecules
Interventional Outcome Studies Based on Removal
Conclusions
References
Beta-2-Microglobulin as a Uremic Toxin: the Japanese Experience
Abstract
Therapeutic Approaches
High-Flux Dialysis
Hemodiafiltration
Hemoadsorption
Conclusion
References
Markers and Possible Uremic Toxins: Japanese Experiences
Abstract
Oxidative Stress and AGEs in ESRD
Vitamin E-Coated Dialysis Membrane
Clinical Effects of Vitamin E-Coated Dialyzer
Conclusion
References
Biocompatibility of the Dialysis Membrane
Abstract
Complement Activation
Contact Pathway Activation
Platelet Activation
Monocyte Activation
Neutrophil Activation
Conclusion
References
Choice of Dialyzers for HDF
Abstract
Materials and Method
Results and Discussion
Conclusions
References
Estimation of Internal Filtration Flow Rate in High-Flux Dialyzers by Doppler Ultrasonography
Abstract
Materials and Methods
Results
Discussions
Conclusions
References
Management of Anemia by Convective Treatments
Abstract
Pathogenesis of Anemia in Chronic Kidney Disease
Anemia and Dialysis Dose
Convective Treatments
Vitamin E-Coated Membranes
Online Treatments
Conclusions
References
Clinical Evaluation Indices for Hemodialysis/Hemodiafiltration in Japan
Abstract
Historical Review of Chronic HD Therapy in Japan
Influence of the Low Prevalence of Renal Transplantation on Chronic HD Therapy in Japan
Impacts of High-Flux Membrane Dialyzers on Clinical Indices of HD Patients
Impacts of HDF on the Clinical Indices of HD Patients
References
Effect of Large-Size Dialysis Membrane and Hemofiltration/Hemodiafiltration Methods on Long-Term Dialysis Patients
Abstract
Development of Protein-Permeable Dialysis Membrane
Removal of Uremic Substances and Loss of Albumin in Low MW Protein Region
Clinical Efficiency
Improvement in Anemia, Osteoarthritis, Pruritus and Irritable Sensation
Attempts Towards the Improvement of Biocompatibility Through the Removal of Complement Factor D
Effects on the Life Prognosis and the Occurrence of Snapping Finger and Carpal Tunnel Syndrome
Decrease in Hospitalization and Complication
Variation in the Serum Albumin Value in HD/HDF Using Protein-Permeable Membrane
Conclusion
References
Who Needs Acetate-Free Biofiltration?
Abstract
Background
Concept of Acetate-Free Biofiltration
Indication for AFB
AFHD vs. AFB
Conclusion
References
Improvement of Autonomic Nervous Regulation by Blood Purification Therapy Using Acetate-Free Dialysis Fluid – Clinical Evaluation by Laser Doppler Flowmetry
Abstract
Evaluation of Autonomic Function by NICOMM
Stability Index of Tissue Blood Flow in the Head
Evaluation of Blood Purification Modalities with the Head SI
Comparison between Healthy Subjects and Stable Dialysis Patients
Comparison between Conventional Hemodialysis and AFHD
Future Prospects for Acetate-Free Dialysis Fluid
Conclusions
References
Preservation of Residual Renal Function with HDF
Abstract
Background
Study 1
Evaluation of the Condition for the Initiation of Water Removal Purpose.
Study 2
Dialysis without Water Removal
Study 3
Examination of the Effects of Online HDF on the RRF
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Tags: Kawanishi, Yamashita, Hemodiafiltration, Era