Histamine and H1 Antihistamines in Allergic Disease Clinical Allergy and Immunology 2nd Edition by F Estelle R Simons ISBN 0824744764 9780824744762

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ISBN 10: 0824744764 
ISBN 13: 9780824744762
Author:  F Estelle R Simons

Building upon the strengths of the best-selling first edition, Histamine and H1-Antihistamines in Allergic Disease, Second Edition presents the latest advances and current research in histamine, histamine receptors, and H1-antihistamines for practical application in allergy, immunology, dermatology, otolaryngology, and pulmonology.

Contains over 2000 contemporary references-300 more than the first edition!

Histamine and H1 Antihistamines in Allergic Disease Clinical Allergy and Immunology 2nd Table of contents:

Part I: Histamine and Histamine Receptors – Basic Science

• Chapter 1: Histamine in Health and Disease
  • Biosynthesis and Metabolism of Histamine
  • Storage and Release of Histamine
  • Physiological and Pathophysiological Roles of Histamine
  • Histamine in Allergic and Non-Allergic Reactions
• Chapter 2: Histamine Receptors: Specific Ligands, Receptor Biochemistry, and Signal Transduction
  • Overview of Histamine Receptors (H1, H2, H3, H4)
  • Molecular Structure and Subtypes of H1 Receptors
  • Signal Transduction Pathways Activated by H1 Receptor Binding
  • Ligands and Their Specificity for H1 Receptors

Part II: H1-Antihistamines – Basic Science and Clinical Pharmacology

• Chapter 3: Structure and Classification of H1-Antihistamines and Overview of Their Activities
  • Chemical Classification of First-Generation H1-Antihistamines
  • Chemical Classification of Second-Generation H1-Antihistamines
  • Pharmacological Properties and Receptor Affinity
  • Inverse Agonism and Receptor Stabilization
• Chapter 4: Antiallergic and Anti-Inflammatory Effects of H1-Antihistamines in Humans
  • Mechanisms Beyond H1 Receptor Blockade
  • Effects on Mast Cell and Basophil Activation
  • Modulation of Cytokine and Chemokine Release
  • Impact on Cellular Adhesion Molecules and Chemotaxis
• Chapter 5: Clinical Pharmacology of H1-Antihistamines
  • Pharmacokinetics (Absorption, Distribution, Metabolism, Excretion) of Key H1-Antihistamines
  • Pharmacodynamics and Dose-Response Relationships
  • Drug Interactions and Special Considerations
  • Comparison of First- and Second-Generation Agents (e.g., sedation, onset of action, duration of action)

Part III: H1-Antihistamines – Clinical Applications in Allergic Diseases

• Chapter 6: Antihistamines in Allergic Rhinoconjunctivitis
  • Pathogenesis of Allergic Rhinitis and Conjunctivitis
  • Role of H1-Antihistamines in Symptom Control (nasal, ocular)
  • Oral vs. Intranasal/Ophthalmic Formulations
  • Combination Therapies
  • Cost-Effectiveness in Management
• Chapter 7: H1-Antihistamines in Asthma
  • Role of Histamine in Asthma Pathogenesis
  • Efficacy of H1-Antihistamines in Asthma Management
  • Impact on Bronchial Hyperresponsiveness and Symptoms
  • Newer Insights and Limitations
• Chapter 8: Antihistamine Treatment of Urticaria and Angioedema
  • Classification and Pathogenesis of Urticaria and Angioedema
  • Role of H1-Antihistamines in Acute and Chronic Urticaria
  • Dosing Strategies for Chronic Urticaria (e.g., up-dosing)
  • Antihistamines in Angioedema Management
• Chapter 9: Histamine and Antihistamines in Anaphylaxis
  • Role of Histamine in Anaphylaxis
  • Limited Role of H1-Antihistamines in Acute Anaphylaxis Management
  • Importance of Epinephrine
  • Use of Antihistamines in Prevention or Adjunctive Therapy
• Chapter 10: H1-Antihistamines in Atopic Dermatitis
  • Pathophysiology of Itch in Atopic Dermatitis
  • Efficacy of H1-Antihistamines for Pruritus Relief
  • Sedating vs. Non-sedating Agents for Sleep Disturbance
• Chapter 11: Cost-Effectiveness of H1-Antihistamines
  • Economic Considerations in Allergic Disease Management
  • Cost-Benefit Analysis of Different H1-Antihistamine Options
  • Impact on Healthcare Resources and Patient Quality of Life

Part IV: H1-Antihistamines – Special Considerations and Future Directions

• Chapter 12: H1-Antihistamines and the Central Nervous System

  • Blood-Brain Barrier Penetration of First- and Second-Generation Agents
  • Sedation, Cognitive Impairment, and Psychomotor Performance
  • Implications for Driving and Daily Activities

• Chapter 13: Potential Cardiac Toxicity of H1-Antihistamines

  • Historical Overview of QT Prolongation and Arrhythmias
  • Cardiac Safety Profiles of Second-Generation Agents
  • Drug Interactions Affecting Cardiac Safety

• Chapter 14: H1-Antihistamines in Pregnancy and Lactation

  • Safety Data and Risk Assessment for Different Agents
  • Guidelines for Use in Pregnant and Breastfeeding Women
  • Transfer into Breast Milk

• Chapter 15: H1-Antihistamines in Children

  • Pharmacokinetics and Pharmacodynamics in Pediatric Populations
  • Efficacy and Safety in Different Age Groups
  • Dosing Recommendations and Formulations for Children

• Chapter 16: H1-Antihistamines in Elderly Patients

  • Considerations for Aging Physiology and Comorbidities
  • Potential for Increased Side Effects

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Tags: F Estelle R Simons, Antihistamines, Allergic Disease