Hormone Replacement Therapy and Cancer The Current Status of Research and Practice 1st Edition by Andrea Genazzani 1003076467 9781842140796

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Product details:

ISBN 10: 1003076467 

ISBN 13: 9781842140796

Author: Andrea R. Genazzani

The clinical benefits of hormone replacement therapy in women have to be carefully balanced against the possible risks, and a particular theoretical concern relates to risks associated with various forms of female oncology. Because of conflicting reports, gynecologists and oncologists especially need a single, authoritative resource of up-to-date information. Hormone Replacement Therapy and Cancer, published in association with the International Menopause Society, provides the very consensus statement that clinicians need in this difficult and complex area. Many of the world’s leading specialists have contributed important chapters that provide state-of-the-art knowledge about the effects of hormones on women and possible cancer risks. The introductory section deals with carcinogenesis, and the other main sections cover HRT and breast cancer, endometrial cancer, colon cancer, melanoma and epithelial ovarian cancer. The concluding chapters discuss the benefits and risks of sp ecific therapies. An authoritative clinical reference with extensive bibliographic references and index, Hormone Replacement Therapy and Cancer covers all aspects of HRT and cancer based on the research available up to June 2001.

Table of contents:

Section I: Carcinogenesis

1 Oncogenes and tumor suppressor genes

2 Telomerase and cancer

3 Matrix metalloproteinases

4 Biological basis of angiogenesis and role of vascular endothelial growth factor-D

Section II: HRT and breast cancer

5 Breast cancer: epidemiology, pathology and natural history

6 Genes and heredity in breast cancer

7 Endocrine, paracrine and intracrine mechanisms of growth regulation in normal and malignant breast epithelium

8 Chemoprevention of breast cancer with tamoxifen: recent experience and future perspectives

9 Hormonal therapy of breast cancer

10 Hormone replacement therapy and mammographic breast density

11 Hormone replacement therapy, insulin-like growth factor I and breast cancer

12 Postmenopausal hormone use and breast cancer risk: reassessment of the evidence

13 The use of hormonal therapy for management of severe postmenopausal symptoms following breast cancer

Section III: HRT and endometrial cancer

14 Endometrial cancer: epidemiology, pathology and natural history

15 Endocrine, paracrine and intracrine mechanisms of growth regulation in normal and malignant endometrial epithelium

16 Chemoprevention and endocrine therapy of endometrial carcinoma

17 Hormone replacement therapy and endometrial cancer

18 Endometrial stromal tumors — are they hormonally sensitive?

Section IV: HRT and colon cancer

19 Epidemiology of colorectal cancer

20 Colon cancer: pathology and natural history

21 Estrogen receptors, estrogens and colon cancer

22 Cyclo-oxygenase-2: an endogenous tumor promoter and target for the chemoprevention of colorectal cancer and other neoplastic diseases

23 Hormone replacement therapy and colon cancer

Section V: HRT and melanoma

24 Cutaneous malignant melanoma: epidemiology, endocrine features and hormone replacement therapy

Section VI: HRT and epithelial ovarian cancer

25 BRCA1-BRCA2 and ovarian cancer

26 Estrogen replacement therapy use and risk of ovarian cancer: results from two Italian studies and review of the literature

Section VII: Selective aspects of specific therapies

27 Understanding HRT risks and benefits and the new science of HRT

28 Pulsed estrogen therapy may lead to lower breast stimulation than with daily continuous estrogen exposure

29 Transdermal estrogen therapy and the risk of breast cancer: a clinical appraisal

30 The effects of selective estrogen receptor modulators on the endometrium

31 Safety and tolerability profile of Livial

32 Preclinical and clinical development of new progesterone receptor antagonists with high receptor specificity for breast cancer treatment

33 More than bones: hormone replacement therapy for mind and body

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