Inflammation and Cancer Methods and Protocols Volume 2 Molecular Analysis and Pathways 1st Edition by Yusuke Hiraku, Shosuke Kawanishi 9781603275309 1603275304

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ISBN 10: 1603275304
ISBN 13: 9781603275309 
Author: Yusuke Hiraku, Shosuke Kawanishi

According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls.

Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.

Inflammation and Cancer Methods and Protocols Volume 2 Molecular Analysis and Pathways 1st Table of contents:

Pt. I.    Crossroads of inflammation and cancer: Molecular Aspects
Immunohistochemical Analysis of 8-Nitroguanine, A Nitrative DNA Lesion, in Relation to Inflammation-Associated Carcinogenesis
           Yusuke Hiraku, Shosuke Kawanishi
Molecular Analysis of Genetic Instability Caused by Chronic Inflammation
           Bin Yan, Yuanlin Peng, Chuan-Yuan Li
Obesity Provides a Permissive Milieu in Inflammation-Associated Carcinogenesis: Analysis of Insulin and IGF Pathways
           Nomeli P. Nunez, Stephen D. Hursting, Shoshana Yakar, Dan Fowler, Charles Vinson
Detecting and Modulating the NF-[kappa]B Activity in Human Immune Cells: Generation of Human Cell Lines with Altered Levels of NF-[kappa]B
           Fui G. Goh, Helen Banks, Irina A. Udalova
Inflammation-Related Aberrant Patterns of DNA Methylation: Detection and Role in Epigenetic Deregulation of Cancer Cell Transcriptome
           Hiromu Suzuki, Minoru Toyota, Yutaka Kondo, Yasuhisa Shinomura
cDNA Microarray Analysis of Inflammatory Breast Cancer Signatures
           Steven J. Van Laere, Peter B. Vermeulen, Luc Y. Dirix
Analysis of the TLR/NF-[kappa]B Pathway in Antigen-Presenting Cells in Malignancies Promoted by Inflammation
           J. Magarian Blander
Induced Nitric Oxide Synthase as a Major Player in the Oncogenic Transformation of Inflamed Tissue
           Guang-Yu Yang, Sofia Taboada, Jie Liao
Pt. II.    Molecular and Cellular Approaches to Diagnostics and Drug Target Discovery in Inflammation-Related Oncogenesis
Development of a Cell-Based Assay to Quantify the Inflammatory Potential of Test Substances and Screen Compound Libraries for Anti-cancer Drug Candidates in a High-Throughput Format
           Serguei V. Kozlov
The NF-[kappa]B Transcription Factor Pathway as a Therapeutic Target in Cancer: Methods for Detection of NF-[kappa]B Activity
           Claudio Mauro, Francesca Zazzeroni, Salvatore Papa, Concetta Bubici, Guido Franzoso
Inhibiting Proinflammatory NF-[kappa]B Signaling Using Cell-Penetrating NEMO Binding Domain Peptides
           Lisa A. Madge, Michael J. May
Quantitative Measurement of Cytokine Expression in Synoviocytes Derived from Rheumatoid Arthritis Patients
           Scott Thomson, Irina A. Udalova
Molecular Characterization of Inflammation-Induced JNK/c-Jun Signaling Pathway in Connection with Tumorigenesis
           Bozena Kaminska
Molecular Characterization of STAT Signaling in Inflammation and Tumorigenesis
           Alicja Adach, Aleksandra Ellert-Miklaszewska, Bozena Kaminska
Inflammation and Tumor Progression: A Lesson from TNF-[alpha]-Dependent FAK Signaling in Cholangiocarcinoma
           Naing Naing Mon, Toshio Kokuryo, Michinari Hamaguchi
Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPAR[delta] [actual symbol not reproducible] 14-3-3[epsilon] Pathway
           Kenneth K. Wu, Jun-Yang Liou
PPAR[beta]/[delta] Agonist Increases the Expression of PGE[subscript 2] Receptor Subtype EP4 in Human Lung Carcinoma Cells
           Jeffrey D. Ritzenthaler, Jesse Roman, Shou Wei Han
Investigating Macrophage and Malignant Cell Interactions In Vitro
           Thorsten Hagemann, Toby Lawrence
Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anticancer Therapy
           Pierre Smirnov
Application of Phage Display to Discovery of Tumor-Specific Homing Peptides: Developing Strategies for Therapy and Molecular Imaging of Cancer
           Seung-Min Lee, Gil-Suk Yoon, Eun-Sang Yoo, Tae-Gyun Kwon, In-San Kim, Byung-Heon Lee
Molecular Basis of Histone Deacetylase Inhibitors as New Drugs for the Treatment of Inflammatory Diseases and Cancer
           Rainer Glauben, Britta Siegmund
Peptide YY Mediates Inhibition of Tumor Growth and Inflammation
           Julie A. Alosi, David W. McFadden

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