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Liquid Biopsies in Solid Tumors 1st Edition by Massimo Cristofanilli ISBN 3319509551 9783319509556

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Liquid Biopsies in Solid Tumors 1st Edition Massimo Cristofanilli Digital Instant Download

Author(s): Massimo Cristofanilli, (ed.)
ISBN(s): 9783319509563, 331950956X
Edition: 1
File Details: PDF, 3.52 MB
Year: 2017
Language: english
SKU: EB-5882132 Category: Tags: ,

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Product details: 

ISBN 10: 3319509551

ISBN 13: 9783319509556

Author: Massimo Cristofanilli 

This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype. Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.

Table of contents: 

Chapter 1: Blood-Based Diagnostics in Solid Tumors: An Overview
Circulating Biomarkers in the Peripheral Blood
Circulating Tumor Cells (CTCs)
Circulating Tumor DNA (ctDNA)
Exosomes
References
Chapter 2: Circulating Tumour Cells in Primary Disease: The Seed for Metastasis
Introduction
Circulating Tumour Cells and the Biology of Metastasis
Definition of Circulating Tumour Cells
Models of Metastatic Progression
The Linear and Parallel Progression Models
Tumour Self-Seeding
Steps in the Invasive: Metastatic Cascade
Local Invasion and Intravasation
Epithelial-Mesenchymal Transition
Survival in the Circulation and Extravasation
Single Circulating Tumour Cells
Clustered Circulating Tumour Cells
Formation of Metastasis
Disseminated Tumour Cells in the Bone Marrow
Dormancy
Stemness
Clinical Applications of Circulating Tumour Cells
Circulating Tumour Cells as Prognostic Factors
Circulating Tumour Cell Characterisation
Interventional Studies
Conclusions
References
Chapter 3: Enumeration and Molecular Analysis of CTCs in Metastatic Disease: The Breast Cancer M
Introduction
Enrichment, Isolation, and Detection of CTCs
Label-Dependent CTC Isolation and Detection Systems
CTC Enrichment and Detection by Positive Immunomagnetic Selection
Microfluidic Based Positive CTC Enrichment
In Vivo Positive Enrichment Technologies
CTC Enrichment by Negative Selection (Label-Independent Techniques)
CTC Enrichment Based on Biophysical Properties (Label-­Independent Techniques)
Size- and/or Deformability-Based Enrichment of CTCs (Microfiltration Systems)
Centrifugation
Dielectrophoresis (DEP)
Imaging Systems for CTC Analysis
Functional Assays
Clinical Significance of CTC Enumeration in Metastatic BrCa
Molecular Characterization of CTCs in Metastatic BrCa: Clinical Significance
Gene Expression Studies in CTCs from Metastatic BrCa Patients
Mutation Detection Studies in CTCs from Metastatic BrCa Patients
DNA Methylation Studies in CTCs from Metastatic BrCa Patients
Single-Cell Analysis in Metastatic BrCa Patients
Quality Control (QC) in CTC Analysis
Conclusions
References
Chapter 4: Epithelial-Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs): The Traveling Met
Introduction
Metastasis
Role of CSCs in Metastasis
Role of Complete and Partial EMT in Promoting CSC Properties
CTCs and Metastasis
CTC with Complete and Partial EMT in Metastasis
Factors Regulating EMT and CSC Properties
CTC as a Traveling Diagnostic and Target for Metastasis
References
Chapter 5: Detecting and Monitoring Circulating Stromal Cells from Solid Tumors Using Blood-Based
Stromal Cells Are Universal Constituents Found in All Solid Tumors and the Future of Diagnostic
Circulating Stromal Cells (CStCs): More Than Just One Needle in a Haystack
TAMs and Circulating CAMLs
Tumor Endothelial Cells and the Circulating Cancer-­Associated Vascular Endothelial Subtype
Cancer-Associated Fibroblasts, Neutrophils, and Other Cell Types
Presence and Prevalence of CTCs and CStCs in Malignant Disease-Reanalyzing Compiled Data Sets
Molecular Abnormalities in Circulation
Immune Checkpoint Therapies and Targeted Therapies, the Future of Cancer Treatment
Total Blood-Based Biopsies: Future Directions
References
Chapter 6: Circulating Free Tumor DNA (ctDNA): The Real-Time Liquid Biopsy
Introduction
Sources of cfDNA
Technologies to Measure ctDNA/ptDNA
Concordance Studies
Clinical Applications: Prevention and Screening
Clinical Applications: Early-Stage Cancer
Clinical Applications: Metastatic Cancer
Conclusions
References
Chapter 7: CTCs and ctDNA: Two Tales of a Complex Biology
Introduction
Advantages and Challenges of Blood-Derived Biopsy
Circulating Tumor Cells
What Impact Does Technology Have on Our Understanding of CTC
Boundaries Between Form and Function of Tumor Cells in Blood
Circulating Tumor DNA
ctDNA Boundaries Determined by Detection Tools
Tying Two Tales Together
References
Chapter 8: Exosomes: The Next Small Thing
Introduction
Discovery
Genesis
Structure and Content
MicroRNAs
mRNA
Proteins
Lipids
Function
Exosomes in Cancer: Angiogenesis, Immunity, and Metastasis
Diagnostic Use
Exosomal Nucleic Acids as Biomarkers
Noninvasive Genotyping
RNA Signatures as Diagnostics
Proteins as BMs
Therapeutic Uses of Exosomes
Clinical Trials of Exosome-Based Therapy

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Massimo Cristofanilli,Biopsies,Tumors